Author results

2SNV
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THE REFINED STRUCTURE OF SINDBIS VIRUS CORE PROTEIN IN COMPARISON WITH OTHER CHYMOTRYPSIN-LIKE SERINE PROTEINASE STRUCTURES
Descriptor:SINDBIS VIRUS COAT PROTEIN
Authors:Tong, L., Rossmann, M.G.
Deposit date:1992-07-17
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures.
J.Mol.Biol., 230, 1993
2WPO
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HCMV PROTEASE INHIBITOR COMPLEX
Descriptor:HUMAN CYTOMEGALOVIRUS PROTEASE, (2S)-2-(3,3-dimethylbutanoylamino)-N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[(4-iodophenyl)methylamino]-4-oxo-butan-2-yl]amino]-1,4-dioxo-4-pyrrol-1-yl-butan-2-yl]-3,3-dimethyl-butanamide
Authors:Tong, L., Qian, C., Massariol, M.-J., Deziel, R., Yoakim, C., Lagace, L.
Deposit date:1998-08-04
Release date:1999-08-04
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease.
Nat.Struct.Biol., 5, 1998
1IDA
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CRYSTAL STRUCTURES OF HIV-2 PROTEASE IN COMPLEX WITH INHIBITORS CONTAINING THE HYDROXYETHYLAMINE DIPEPTIDE ISOSTERE
Descriptor:Protease, N-[(1R)-1-{[(1S,2S)-1-benzyl-3-{(2R,4S)-2-(tert-butylcarbamoyl)-4-[(pyridin-3-ylmethyl)sulfanyl]piperidin-1-yl}-2-hydroxypropyl]carbamoyl}-2-methylpropyl]quinoline-2-carboxamide
Authors:Tong, L., Anderson, P.C.
Deposit date:1994-10-19
Release date:1995-01-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.
Structure, 3, 1995
1IDB
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CRYSTAL STRUCTURES OF HIV-2 PROTEASE IN COMPLEX WITH INHIBITORS CONTAINING THE HYDROXYETHYLAMINE DIPEPTIDE ISOSTERE
Descriptor:HIV-2 PROTEASE, (2R,4S)-N-tert-butyl-1-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutyl]-4-(pyridin-4-ylsulfonyl)piperidine-2-carboxamide
Authors:Tong, L., Anderson, P.C.
Deposit date:1994-10-19
Release date:1995-01-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.
Structure, 3, 1995
1HRN
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HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS
Descriptor:RENIN, N-ACETYL-D-GLUCOSAMINE, (2R,4S,5S)-N-[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]-2-(cyclopropylmethyl)-4,5-dihydroxy-6-phenylhexanamide
Authors:Tong, L., Anderson, P.C.
Deposit date:1995-03-31
Release date:1995-06-03
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors.
J.Mol.Biol., 250, 1995
1WPO
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HYDROLYTIC ENZYME HUMAN CYTOMEGALOVIRUS PROTEASE
Descriptor:HUMAN CYTOMEGALOVIRUS PROTEASE, SULFATE ION
Authors:Tong, L.
Deposit date:1996-07-23
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease.
Nature, 383, 1996
1BHF
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P56LCK SH2 DOMAIN INHIBITOR COMPLEX
Descriptor:T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK, INHIBITOR ACE-IPA-GLU-GLU-ILE
Authors:Tong, L., Warren, T.C., Lukas, S., Schembri-King, J., Betageri, R., Proudfoot, J.R., Jakes, S.
Deposit date:1998-06-08
Release date:1998-10-21
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
1BHH
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FREE P56LCK SH2 DOMAIN
Descriptor:T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK, P56 LCK TYROSINE KINASE SH2 DOMAIN
Authors:Tong, L., Warren, T.C., Lukas, S., Schembri-King, J., Betageri, R., Proudfoot, J.R., Jakes, S.
Deposit date:1998-06-08
Release date:1998-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
1BIL
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CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS
Descriptor:Renin, (2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-[(1S,2R,3R)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-N~4~-[2-(dimethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide
Authors:Tong, L.
Deposit date:1995-09-27
Release date:1996-01-29
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.
J.Biol.Chem., 270, 1995
1BIM
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CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS
Descriptor:Renin, (2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-{(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-2-[(3R)-1,5,5-trimethyl-2-oxopyrrolidin-3-yl]ethyl}-N~4~-[2-(dimethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide
Authors:Tong, L.
Deposit date:1995-09-27
Release date:1996-01-29
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.
J.Biol.Chem., 270, 1995
1IAN
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HUMAN P38 MAP KINASE INHIBITOR COMPLEX
Descriptor:P38 MAP KINASE, 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE
Authors:Tong, L.
Deposit date:1997-03-07
Release date:1998-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket.
Nat.Struct.Biol., 4, 1997
1LKK
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HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE)
Descriptor:HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE, ACETYL GROUP
Authors:Tong, L.
Deposit date:1995-11-10
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution.
J.Mol.Biol., 256, 1996
1LKL
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HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE)
Descriptor:HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY
Authors:Tong, L.
Deposit date:1995-11-10
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution.
J.Mol.Biol., 256, 1996
2MIP
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CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) TYPE 2 PROTEASE IN COMPLEX WITH A REDUCED AMIDE INHIBITOR AND COMPARISON WITH HIV-1 PROTEASE STRUCTURES
Descriptor:HIV-2 PROTEASE, INHIBITOR BI-LA-398
Authors:Tong, L., Pav, S., Pargellis, C., Do, F., Lamarre, D., Anderson, P.C.
Deposit date:1993-06-03
Release date:1993-10-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures.
Proc.Natl.Acad.Sci.USA, 90, 1993
6DKN
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA DECAPPING NUCLEASE DXO1
Descriptor:Decapping nuclease DXO homolog, chloroplastic
Authors:Tong, L., Wang, V.Y.F.
Deposit date:2018-05-30
Release date:2019-02-27
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity.
Nucleic Acids Res., 47, 2019
1JLD
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POTENT HIV PROTEASE INHIBITORS CONTAINING A NOVEL (HYDROXYETHYL)AMIDE ISOSTERE
Descriptor:HIV-2 PROTEASE, (2S)-2-tert-butyl-N~4~-(1-ethylpropyl)-N~1~-[(2R,3S)-2-hydroxy-4-phenyl-3-{[N-(quinolin-2-ylcarbonyl)-L-threonyl]amino}butyl]butanediamide
Authors:Tong, L.
Deposit date:1997-05-31
Release date:1997-12-03
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.
J.Med.Chem., 40, 1997
3HB9
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CRYSTAL STRUCTURE OF S. AUREUS PYRUVATE CARBOXYLASE A610T MUTANT
Descriptor:Pyruvate carboxylase, 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Tong, L., Yu, L.P.C.
Deposit date:2009-05-04
Release date:2009-06-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3HBL
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CRYSTAL STRUCTURE OF S. AUREUS PYRUVATE CARBOXYLASE T908A MUTANT
Descriptor:Pyruvate carboxylase, 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, MANGANESE (II) ION, ...
Authors:Tong, L., Yu, L.P.C.
Deposit date:2009-05-04
Release date:2009-06-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3HO8
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CRYSTAL STRUCTURE OF S. AUREUS PYRUVATE CARBOXYLASE IN COMPLEX WITH COENZYME A
Descriptor:Pyruvate carboxylase, COENZYME A, MANGANESE (II) ION, ...
Authors:Tong, L., Yu, L.P.C.
Deposit date:2009-06-01
Release date:2009-06-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3O2Q
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CRYSTAL STRUCTURE OF THE HUMAN SYMPLEKIN-SSU72-CTD PHOSPHOPEPTIDE COMPLEX
Descriptor:Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, RNA polymerase II CTD Serine-5 phosphopeptide, ...
Authors:Tong, L., Xiang, K.
Deposit date:2010-07-22
Release date:2010-10-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3O2S
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CRYSTAL STRUCTURE OF THE HUMAN SYMPLEKIN-SSU72 COMPLEX
Descriptor:Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, PHOSPHATE ION
Authors:Tong, L., Xiang, K.
Deposit date:2010-07-22
Release date:2010-10-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3O2T
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN SYMPLEKIN
Descriptor:Symplekin, 1,2-ETHANEDIOL
Authors:Tong, L., Xiang, K., Xiang, S.
Deposit date:2010-07-22
Release date:2010-10-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3ODR
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN SYMPLEKIN
Descriptor:Symplekin, 1,2-ETHANEDIOL
Authors:Tong, L., Xiang, K.
Deposit date:2010-08-11
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3ODS
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CRYSTAL STRUCTURE OF THE K185A MUTANT OF THE N-TERMINAL DOMAIN OF HUMAN SYMPLEKIN
Descriptor:Symplekin, 1,2-ETHANEDIOL
Authors:Tong, L., Xiang, K.
Deposit date:2010-08-11
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3PGQ
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CRYSTAL STRUCTURE OF THE CARBOXYLTRANSFERASE DOMAIN OF S. CEREVISIAE ACETYL COA CARBOXYLASE IN COMPLEX WITH PINOXADEN
Descriptor:Acetyl-CoA carboxylase, 8-(2-ethenyl-6-ethyl-4-methylphenyl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
Authors:Tong, L., Yu, L.P.C., Kim, Y.S.
Deposit date:2010-11-02
Release date:2010-12-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden.
Proc.Natl.Acad.Sci.USA, 107, 2010