Author results

4UXN
  • Download 4uxn
  • View 4uxn
Molmil generated image of 4uxn
LSD1(KDM1A)-COREST IN COMPLEX WITH Z-PRO DERIVATIVE OF MC2580
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Rodriguez, V., Valente, S., Stazi, G., Lucidi, A., Mercurio, C., Vianello, P., Ciossani, G., Mattevi, A., Botrugno, O.A., Dessanti, P., Minucci, S., Varasi, M., Mai, A.
Deposit date:2014-08-27
Release date:2015-02-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells
Chemmedchem, 6, 2015
6GOU
  • Download 6gou
  • View 6gou
Molmil generated image of 6gou
DEVELOPMENT OF ALKYL GLYCERONE PHOSPHATE SYNTHASE INHIBITORS: COMPLEX WITH INHIBITOR 2I
Descriptor:Alkyldihydroxyacetonephosphate synthase, peroxisomal, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Mattevi, A., Piano, V.
Deposit date:2018-06-04
Release date:2019-01-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.
Eur J Med Chem, 163, 2018
6FSY
  • Download 6fsy
  • View 6fsy
Molmil generated image of 6fsy
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A 3,5-DIMETHYLISOXAZOL LIGAND
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol
Authors:Filippakopoulos, P., Picaud, S., Conway, S.J., Pike, A.C.W., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Structural Genomics Consortium (SGC)
Deposit date:2018-02-20
Release date:2018-04-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Bioorg.Med.Chem., 26, 2018
6FT3
  • Download 6ft3
  • View 6ft3
Molmil generated image of 6ft3
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A 3,5-DIMETHYLISOXAZOL LIGAND
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-[(~{R})-cyclopropyl(oxidanyl)methyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)phenol
Authors:Filippakopoulos, P., Picaud, S., Pike, A.C.W., Krojer, T., Conway, S.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Structural Genomics Consortium (SGC)
Deposit date:2018-02-20
Release date:2018-04-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Bioorg.Med.Chem., 26, 2018
6FT4
  • Download 6ft4
  • View 6ft4
Molmil generated image of 6ft4
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A 3,5-DIMETHYLISOXAZOL LIGAND
Descriptor:Bromodomain-containing protein 4, 3-[[4,4-bis(fluoranyl)piperidin-1-yl]methyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)phenol
Authors:Filippakopoulos, P., Picaud, S., Pike, A.C.W., Krojer, T., Conway, S.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2018-02-20
Release date:2018-04-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Bioorg.Med.Chem., 26, 2018
171916
PDB entries from 2020-12-02