6FT4

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Summary for 6FT4

• Entry DOI: 10.2210/pdb6ft4/pdb
• Descriptor: Bromodomain-containing protein 4, 3-[[4,4-bis(fluoranyl)piperidin-1-yl]methyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)phenol (3 entities in total)
• Functional Keywords: bromodomain, ligand, transcription, isoxazole
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15421.73

Authors

Filippakopoulos, P.,Picaud, S.,Pike, A.C.W.,Krojer, T.,Conway, S.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C. (deposition date: 2018-02-20, release date: 2018-04-18, Last modification date: 2024-01-17)

• Primary citation: Jennings, L.E.,Schiedel, M.,Hewings, D.S.,Picaud, S.,Laurin, C.M.C.,Bruno, P.A.,Bluck, J.P.,Scorah, A.R.,See, L.,Reynolds, J.K.,Moroglu, M.,Mistry, I.N.,Hicks, A.,Guzanov, P.,Clayton, J.,Evans, C.N.G.,Stazi, G.,Biggin, P.C.,Mapp, A.K.,Hammond, E.M.,Humphreys, P.G.,Filippakopoulos, P.,Conway, S.J.; BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.; Bioorg.Med.Chem., 26:2937-2957, 2018; PubMed: 29776834; DOI: 10.1016/j.bmc.2018.05.003

Experimental method

X-RAY DIFFRACTION (1.34 Å)