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1B0T
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D15K/K84D MUTANT OF AZOTOBACTER VINELANDII FDI
Descriptor:PROTEIN (FERREDOXIN I), IRON/SULFUR CLUSTER, FE3-S4 CLUSTER
Authors:Sridhar, V., Stout, C.D., Chen, K., Kemper, M.A., Burgess, B.K.
Deposit date:1998-11-12
Release date:1998-11-25
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the D15K/K84D Mutant of Azotobacter Vinelandii Ferredoxin I
To be Published
4LKQ
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT017
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-08
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LLJ
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT214
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2H-isoindole-1,3-diamine, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-09
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LLK
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT217
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2-methylquinazolin-4(3H)-one, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-09
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LLP
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT401
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 4-amino-2-methylphenol, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-09
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LLX
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT434
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 4,6-dimethylpyrimidin-2-amine, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-09
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM0
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT448
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 5-NITROINDAZOLE, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-09
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM1
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT450
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 5-nitroquinoline, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-09
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM2
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT462
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2,3-dihydro-1,4-benzodioxin-6-ylmethanol, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-09
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM3
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT464
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone, NICKEL (II) ION, ...
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-09
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM4
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT902
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, quinazolin-4(1H)-one, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-07-10
Release date:2014-02-26
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4MRW
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT0120 (7-CHLOROQUINOLIN-4-OL)
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 7-chloroquinolin-4-ol, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., NIenaber, V.
Deposit date:2013-09-17
Release date:2014-05-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen, 19, 2014
4MRZ
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT0429 (4-METHYL-3-NITROPYRIDIN-2-AMINE)
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 4-methyl-3-nitropyridin-2-amine, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-09-17
Release date:2014-05-14
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen, 19, 2014
4MS0
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT0443 (6-CHLOROPYRIMIDINE-2,4-DIAMINE)
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 6-chloropyrimidine-2,4-diamine, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-09-18
Release date:2014-05-14
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen, 19, 2014
4MSC
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT1595 (2-[(QUINOLIN-7-YLOXY)METHYL]QUINOLINE)
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2-[(quinolin-7-yloxy)methyl]quinoline, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-09-18
Release date:2014-05-14
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen, 19, 2014
4MSE
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT1597 (2-({[(2S)-2-METHYL-2,3-DIHYDRO-1,3-BENZOTHIAZOL-5-YL]OXY}METHYL)QUINOLINE)
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2-{[(2-methyl-1,3-benzothiazol-5-yl)oxy]methyl}quinoline, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-09-18
Release date:2014-05-14
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen, 19, 2014
4MSH
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT0143 ((2S)-4-CHLORO-2,3-DIHYDRO-1,3-BENZOTHIAZOL-2-AMINE)
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 4-chloro-1,3-benzothiazol-2-amine, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-09-18
Release date:2014-05-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen, 19, 2014
4MSN
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CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT0451 (8-NITROQUINOLINE)
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 8-nitroquinoline, NICKEL (II) ION
Authors:Sridhar, V., Badger, J., Logan, C., Chie-Leon, B., Nienaber, V.
Deposit date:2013-09-18
Release date:2014-05-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen, 19, 2014
1B0V
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I40N MUTANT OF AZOTOBACTER VINELANDII FDI
Descriptor:PROTEIN (FERREDOXIN), IRON/SULFUR CLUSTER, 2,4,6,7-tetrathia-1$l^{3},3$l^{2},5$l^{3}-triferrabicyclo[3.1.1]heptane
Authors:Sridhar, V., Prasad, G.S., Stout, C.D., Chen, K., Burgess, B.K.
Deposit date:1998-11-12
Release date:2000-01-19
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Alteration of the reduction potential of the [4Fe-4S](2+/+) cluster of Azotobacter vinelandii ferredoxin I.
J.Biol.Chem., 274, 1999
4POK
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CRYSTAL STRUCTURES OF THIOREDOXIN WITH MESNA AT 2.5A RESOLUTION
Descriptor:Thioredoxin, 1-THIOETHANESULFONIC ACID
Authors:Sridhar, V., Chie-Leon, B., Badger, J., Nienaber, V.L., Hausheer, F.H.
Deposit date:2014-02-25
Release date:2014-10-29
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity
J Pharmacol Clin Toxicol, 2, 2014
4POL
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CRYSTAL STRUCTURES OF THIOREDOXIN WITH MESNA AT 2.8A RESOLUTION
Descriptor:Thioredoxin, 1-THIOETHANESULFONIC ACID
Authors:Sridhar, V., Chie-Leon, B., Badger, J., Nienaber, V.L., Hausheer, F.H.
Deposit date:2014-02-26
Release date:2014-10-29
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity
J Pharmacol Clin Toxicol, 2, 2014
4POM
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CRYSTAL STRUCTURES OF THIOREDOXIN WITH MESNA AT 1.85A RESOLUTION
Descriptor:Thioredoxin, 1-THIOETHANESULFONIC ACID
Authors:Sridhar, V., Chie-Leon, B., Badger, J., Nienaber, V.L., Hausheer, F.H.
Deposit date:2014-02-26
Release date:2014-10-29
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity
J Pharmacol Clin Toxicol, 2, 2014
3M17
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CRYSTAL STRUCTURE OF HUMAN FCRN WITH A MONOMERIC PEPTIDE INHIBITOR
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, monomeric peptide inhibitor
Authors:Mezo, A.R., Sridhar, V., Badger, J., Sakorafas, P., Nienaber, V.
Deposit date:2010-03-04
Release date:2010-06-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.
J.Biol.Chem., 285, 2010
3M1B
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CRYSTAL STRUCTURE OF HUMAN FCRN WITH A DIMERIC PEPTIDE INHIBITOR
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, DIMERIC PEPTIDE INHIBITOR
Authors:Mezo, A.R., Sridhar, V., Badger, J., Sakorafas, P., Nienaber, V.
Deposit date:2010-03-04
Release date:2010-06-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.
J.Biol.Chem., 285, 2010
3PMO
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THE STRUCTURE OF LPXD FROM PSEUDOMONAS AERUGINOSA AT 1.3 A RESOLUTION
Descriptor:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Badger, J., Chie-Leon, B., Logan, C., Sridhar, V., Sankaran, B., Zwart, P.H., Nienaber, V.
Deposit date:2010-11-17
Release date:2011-07-27
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution.
Acta Crystallogr.,Sect.F, 67, 2011
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