Author results

5LAE
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CRYSTAL STRUCTURE OF MURINE N1-ACETYLPOLYAMINE OXIDASE
Descriptor:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Sjogren, T., Aagaard, A., Snijder, A., Barlind, L.
Deposit date:2016-06-14
Release date:2017-03-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5LFO
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CRYSTAL STRUCTURE OF MURINE N1-ACETYLPOLYAMINE OXIDASE IN COMPLEX WITH N1-ACETYLSPERMINE
Descriptor:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, FLAVIN-ADENINE DINUCLEOTIDE, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, ...
Authors:Sjogren, T., Aagaard, A., Wassvik, C., Snijder, A., Barlind, L.
Deposit date:2016-07-04
Release date:2017-03-15
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5LGB
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CRYSTAL STRUCTURE OF MURINE N1-ACETYLPOLYAMINE OXIDASE IN COMPLEX WITH MDL72527
Descriptor:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, FAD-MDL72527 adduct, N,N'-BIS(2,3-BUTADIENYL)-1,4-BUTANE-DIAMINE
Authors:Sjogren, T., Aagaard, A., Wassvik, C., Snijder, A., Barlind, L.
Deposit date:2016-07-06
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5MBX
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CRYSTAL STRUCTURE OF REDUCED MURINE N1-ACETYLPOLYAMINE OXIDASE IN COMPLEX WITH N1-ACETYLSPERMINE
Descriptor:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, FLAVIN-ADENINE DINUCLEOTIDE, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, ...
Authors:Sjogren, T., Aagaard, A., Wassvik, C., Snijder, A., Barlind, L.
Deposit date:2016-11-09
Release date:2017-01-18
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5NDD
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CRYSTAL STRUCTURE OF A THERMOSTABILISED HUMAN PROTEASE-ACTIVATED RECEPTOR-2 (PAR2) IN COMPLEX WITH AZ8838 AT 2.8 ANGSTROM RESOLUTION
Descriptor:Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, (~{S})-(4-fluoranyl-2-propyl-phenyl)-(1~{H}-imidazol-2-yl)methanol, SODIUM ION, ...
Authors:Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N.
Deposit date:2017-03-08
Release date:2017-05-03
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
5NDZ
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CRYSTAL STRUCTURE OF A THERMOSTABILISED HUMAN PROTEASE-ACTIVATED RECEPTOR-2 (PAR2) IN COMPLEX WITH AZ3451 AT 3.6 ANGSTROM RESOLUTION
Descriptor:Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, 2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide, SODIUM ION
Authors:Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N.
Deposit date:2017-03-09
Release date:2017-05-03
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
5NJ6
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CRYSTAL STRUCTURE OF A THERMOSTABILISED HUMAN PROTEASE-ACTIVATED RECEPTOR-2 (PAR2) IN TERNARY COMPLEX WITH FAB3949 AND AZ7188 AT 4.0 ANGSTROM RESOLUTION
Descriptor:Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, Fab3949 H, Fab3949 L
Authors:Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N.
Deposit date:2017-03-28
Release date:2017-05-03
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
2GNU
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THE CRYSTALLIZATION OF REACTION CENTER FROM RHODOBACTER SPHAEROIDES OCCURS VIA A NEW ROUTE
Descriptor:Reaction center protein H chain, Reaction center protein L chain, Reaction center protein M chain, ...
Authors:Wadsten, P., Woehri, A.B., Snijder, A., Katona, G., Gardiner, A.T., Cogdell, R.J., Neutze, R., Engstroem, S.
Deposit date:2006-04-11
Release date:2006-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Lipidic sponge phase crystallization of membrane proteins
J.Mol.Biol., 364, 2006
4CTH
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NEPRILYSIN VARIANT G399V,G714K IN COMPLEX WITH PHOSPHORAMIDON
Descriptor:NEPRILYSIN, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Webster, C.I., Burrell, M., Olsson, L., Fowler, S.B., Digby, S., Sandercock, A., Snijder, A., Tebbe, J., Haupts, U., Grudzinska, J., Jermutus, L., Andersson, C.
Deposit date:2014-03-13
Release date:2014-08-13
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer'S Disease.
Plos One, 9, 2014
2BNP
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LIPIDIC CUBIC PHASE GROWN REACTION CENTRE FROM RHODOBACTER SPHAEROIDES, GROUND STATE
Descriptor:Reaction center protein L chain, Reaction center protein M chain, Reaction center protein H chain, ...
Authors:Katona, G., Snijder, A., Gourdon, P., Andreasson, U., Hansson, O., Andreasson, L.E., Neutze, R.
Deposit date:2005-03-31
Release date:2005-05-27
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational Regulation of Charge Recombination Reactions in a Photosynthetic Bacterial Reaction Centre
Nat.Struct.Mol.Biol., 12, 2005
2BNS
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LIPIDIC CUBIC PHASE GROWN REACTION CENTRE FROM RHODOBACTER SPHAEROIDES, EXCITED STATE
Descriptor:Reaction center protein L chain, Reaction center protein M chain, Reaction center protein H chain, ...
Authors:Katona, G., Snijder, A., Gourdon, P., Andreasson, U., Hansson, O., Andreasson, L.E., Neutze, R.
Deposit date:2005-03-31
Release date:2005-05-27
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformational Regulation of Charge Recombination Reactions in a Photosynthetic Bacterial Reaction Centre
Nat.Struct.Mol.Biol., 12, 2005
6QZR
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14-3-3 SIGMA IN COMPLEX WITH FOXO1 PT24 PEPTIDE
Descriptor:14-3-3 protein sigma, Forkhead box protein O1, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Ottmann, C., Wolter, M., Lau, R.A.
Deposit date:2019-03-12
Release date:2019-07-31
Last modified:2019-09-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
J.Biol.Chem., 294, 2019
6QZS
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14-3-3 SIGMA IN COMPLEX WITH FOXO1 PS256 PEPTIDE
Descriptor:14-3-3 protein sigma, FOXO1 pS256 site, GLYCEROL, ...
Authors:Ottmann, C., Wolter, M., Lau, R.A.
Deposit date:2019-03-12
Release date:2019-07-31
Last modified:2019-09-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
J.Biol.Chem., 294, 2019
6SD9
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CRYSTAL STRUCTURE OF WILD-TYPE CMET BOUND BY FORETINIB
Descriptor:Hepatocyte growth factor receptor, CHLORIDE ION, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Authors:Collie, G.W., Phillips, C.
Deposit date:2019-07-26
Release date:2019-08-14
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6SDC
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CRYSTAL STRUCTURE OF D1228V CMET BOUND BY FORETINIB
Descriptor:Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Authors:Collie, G.W., Phillips, C.
Deposit date:2019-07-26
Release date:2019-08-14
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6SDD
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CRYSTAL STRUCTURE OF D1228V CMET BOUND BY BMS-777607
Descriptor:Hepatocyte growth factor receptor, N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, GLYCEROL
Authors:Collie, G.W., Phillips, C.
Deposit date:2019-07-26
Release date:2019-08-14
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6SDE
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CRYSTAL STRUCTURE OF WILD-TYPE CMET BOUND BY SAVOLITINIB
Descriptor:Hepatocyte growth factor receptor, volitinib
Authors:Collie, G.W., Phillips, C.
Deposit date:2019-07-26
Release date:2019-08-14
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Acs Med.Chem.Lett., 10, 2019
2RDD
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X-RAY CRYSTAL STRUCTURE OF ACRB IN COMPLEX WITH A NOVEL TRANSMEMBRANE HELIX.
Descriptor:Acriflavine resistance protein B, UPF0092 membrane protein yajC, (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
Authors:Tornroth-Horsefield, S., Gourdon, P., Horsefield, R., Neutze, R.
Deposit date:2007-09-22
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist.
Structure, 15, 2007
5JNQ
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MRAY TUNICAMYCIN COMPLEX
Descriptor:Phospho-N-acetylmuramoyl-pentapeptide-transferase, Tunicamycin, PALMITIC ACID, ...
Authors:Johansson, P.
Deposit date:2016-04-30
Release date:2017-01-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:MraY-antibiotic complex reveals details of tunicamycin mode of action.
Nat. Chem. Biol., 13, 2017