Author results

1ZZQ
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RAT NNOS D597N MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZR
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RAT NNOS D597N/M336V DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ZINC ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZS
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BOVINE ENOS N368D SINGLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZT
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BOVINE ENOS N368D/V106M DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZU
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RAT NNOS D597N/M336V DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1P6H
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RAT NEURONAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6I
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RAT NEURONAL NOS HEME DOMAIN WITH (4S)-N-(4-AMINO-5-[AMINOETHYL]AMINOPENTYL)-N'-NITROGUANIDINE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6J
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RAT NEURONAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6K
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RAT NEURONAL NOS D597N MUTANT HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, D-MANNITOL, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6L
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BOVINE ENDOTHELIAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6M
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BOVINE ENDOTHELIAL NOS HEME DOMAIN WITH (4S)-N-(4-AMINO-5-[AMINOETHYL]AMINOPENTYL)-N'-NITROGUANIDINE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6N
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BOVINE ENDOTHELIAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1Q2O
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BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE N368D MUTANT HEME DOMAIN DIMER WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRAMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-07-25
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1RS6
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RAT NEURONAL NOS HEME DOMAIN WITH D-LYSINE-D-NITROARGININE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, D-MANNITOL, ...
Authors:Flinspach, M., Li, H., Jamal, J., Yang, W., Huang, H., Silverman, R.B., Poulos, T.L.
Deposit date:2003-12-09
Release date:2004-05-18
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Neuronal and Endothelial Nitric Oxide Synthase Heme Domain with d-Nitroarginine-Containing Dipeptide Inhibitors Bound.
Biochemistry, 43, 2004
1RS7
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RAT NEURONAL NOS HEME DOMAIN WITH D-PHENYLALANINE-D-NITROARGININE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M., Li, H., Jamal, J., Yang, W., Huang, H., Silverman, R.B., Poulos, T.L.
Deposit date:2003-12-09
Release date:2004-05-18
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Neuronal and Endothelial Nitric Oxide Synthase Heme Domain with d-Nitroarginine-Containing Dipeptide Inhibitors Bound.
Biochemistry, 43, 2004
1RS8
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BOVINE ENDOTHELIAL NOS HEME DOMAIN WITH D-LYSINE-D-NITROARGININE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M., Li, H., Jamal, J., Yang, W., Huang, H., Silverman, R.B., Poulos, T.L.
Deposit date:2003-12-09
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.
Biochemistry, 43, 2004
1RS9
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BOVINE ENDOTHELIAL NOS HEME DOMAIN WITH D-PHENYLALANINE-D-NITROARGININE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M., Li, H., Jamal, J., Yang, W., Huang, H., Silverman, R.B., Poulos, T.L.
Deposit date:2003-12-09
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.
Biochemistry, 43, 2004
2Q7W
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STRUCTURAL STUDIES REVEALS THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE (S)-4,5-AMINO-DIHYDRO-2-THIOPHENECARBOXYLIC ACID (SADTA) VIA TWO MECHANISMS AT PH 6.0
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-07
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inactivation of Escherichia coli l-Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid Reveals "A Tale of Two Mechanisms".
Biochemistry, 46, 2007
2QA3
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STRUCTURAL STUDIES REVEAL THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE BY (S)-4,5-AMINO-DIHYDRO-2-THIOPHENECARBOXYLIC ACID (SADTA) VIA TWO MECHANISMS (AT PH6.5)
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-14
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
2QB2
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STRUCTURAL STUDIES REVEAL THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE BY (S)-4,5-DIHYDRO-2THIOPHENECARBOYLIC ACID (SADTA) VIA TWO MECHANISMS (AT PH 7.0).
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-15
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
2QB3
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STRUCTURAL STUDIES REVEAL THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE BY (S)-4,5-DIHYDRO-2-THIOPHENECARBOXYLIC ACID (SADTA) VIA TWO MECHANISMS (AT PH 7.5)
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-15
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
2QBT
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STRUCTURAL STUDIES REVEAL THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE BY (S)-4,5-AMINO-DIHYDRO-2-THIOPHENECARBOXYLIC ACID (SADTA) VIA TWO MECHANISMS (AT PH 8.0)
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-18
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inactivation of Escherichia coli l-Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid Reveals "A Tale of Two Mechanisms".
Biochemistry, 46, 2007
3LQS
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COMPLEX STRUCTURE OF D-AMINO ACID AMINOTRANSFERASE AND 4-AMINO-4,5-DIHYDRO-THIOPHENECARBOXYLIC ACID (ADTA)
Descriptor:D-alanine aminotransferase, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ACETIC ACID
Authors:Lepore, B.W., Liu, D., Peng, Y., Fu, M., Yasuda, C., Manning, J.M., Silverman, R.B., Ringe, D.
Deposit date:2010-02-10
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.
Biochemistry, 49, 2010
3NLD
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 6-{{(3'S,4'S)-3'-[2"-(3'''-FLUOROPHENETHYLAMINO)ETHOXY]PYRROLIDIN-4'-YL}METHYL}-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Ji, H., Delker, S.L., Li, H., Martasek, P., Roman, L., Poulos, T.L., Silverman, R.B.
Deposit date:2010-06-21
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives.
J.Med.Chem., 53, 2010
3NLE
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 6-{{(3'R,4'R)-3'-[2"-(3'''-FLUOROPHENETHYLAMINO)ETHOXY]PYRROLIDIN-4'-YL}METHYL}-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Ji, H., Delker, S.L., Li, H., Martasek, P., Roman, L., Poulos, T.L., Silverman, R.B.
Deposit date:2010-06-21
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives.
J.Med.Chem., 53, 2010