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2ISY
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CRYSTAL STRUCTURE OF THE NICKEL-ACTIVATED TWO-DOMAIN IRON-DEPENDENT REGULATOR (IDER)
Descriptor:Iron-dependent repressor ideR, NICKEL (II) ION, PHOSPHATE ION
Authors:Wisedchaisri, G., Chou, C.J., Wu, M., Roach, C., Rice, A.E., Holmes, R.K., Beeson, C., Hol, W.G.
Deposit date:2006-10-18
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.955 Å)
Cite:Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis
Biochemistry, 46, 2007
2ISZ
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CRYSTAL STRUCTURE OF A TWO-DOMAIN IDER-DNA COMPLEX CRYSTAL FORM I
Descriptor:mbtA/mbtB operator strand 1, mbtA/mbtB operator strand 2, Iron-dependent repressor ideR, ...
Authors:Wisedchaisri, G., Chou, C.J., Wu, M., Roach, C., Rice, A.E., Holmes, R.K., Beeson, C., Hol, W.G.
Deposit date:2006-10-18
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis
Biochemistry, 46, 2007
2IT0
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CRYSTAL STRUCTURE OF A TWO-DOMAIN IDER-DNA COMPLEX CRYSTAL FORM II
Descriptor:mbtA/mbtB operator strand 1, mbtA/mbtB operator strand 2, Iron-dependent repressor ideR, ...
Authors:Wisedchaisri, G., Chou, C.J., Wu, M., Roach, C., Rice, A.E., Holmes, R.K., Beeson, C., Hol, W.G.
Deposit date:2006-10-18
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis
Biochemistry, 46, 2007
1HXI
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AN UNEXPECTED EXTENDED CONFORMATION FOR THE THIRD TPR MOTIF OF THE PEROXIN PEX5 FROM TRYPANOSOMA BRUCEI
Descriptor:PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5, MAGNESIUM ION
Authors:Kumar, A., Roach, C., Hirsh, I.S., Turley, S., deWalque, S., Michels, P.A.M., Hol, W.G.J.
Deposit date:2001-01-15
Release date:2001-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei.
J.Mol.Biol., 307, 2001
1MD2
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CHOLERA TOXIN B-PENTAMER WITH DECAVALENT LIGAND BMSC-0013
Descriptor:CHOLERA TOXIN B SUBUNIT, [5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLCARBAMOYL)-PENTYL]-CARBAMIC ACID METHYL ESTER, 3-ETHYLAMINO-4-METHYLAMINO-CYCLOBUTANE-1,2-DIONE, ...
Authors:Zhang, Z., Merritt, E.A., Ahn, M., Roach, C., Hol, W.G.J., Fan, E.
Deposit date:2002-08-06
Release date:2002-12-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.
J.Am.Chem.Soc., 124, 2002
3CV0
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STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING DOMAIN OF TRYPANOSOMA BRUCEI PEROXIN 5 (TBPEX5)COMPLEXED TO T. BRUCEI PHOSPHOGLUCOISOMERASE (PGI) PTS1 PEPTIDE
Descriptor:Peroxisome targeting signal 1 receptor PEX5, T. brucei PGI PTS1 peptide Ac-FNELSHL, 1,2-ETHANEDIOL
Authors:Sampathkumar, P., Roach, C., Michels, P.A.M., Hol, W.G.J.
Deposit date:2008-04-17
Release date:2008-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVL
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STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING DOMAIN OF TRYPANOSOMA BRUCEI PEROXIN 5 (TBPEX5)COMPLEXED TO T. BRUCEI PHOSPHOFRUCTOKINASE (PFK) PTS1 PEPTIDE
Descriptor:Peroxisome targeting signal 1 receptor PEX5, T. brucei PFK PTS1 peptide Ac-HEELAKL
Authors:Sampathkumar, P., Roach, C., Michels, P.A.M., Hol, W.G.J.
Deposit date:2008-04-18
Release date:2008-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVN
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STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING DOMAIN OF TRYPANOSOMA BRUCEI PEROXIN 5 (TBPEX5)COMPLEXED TO T. BRUCEI GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) PTS1 PEPTIDE
Descriptor:Peroxisome targeting signal 1 receptor, T. brucei GAPDH PTS1 peptide Ac-DRDAAKL, 1,2-ETHANEDIOL
Authors:Sampathkumar, P., Roach, C., Michels, P.A.M., Hol, W.G.J.
Deposit date:2008-04-18
Release date:2008-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVP
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STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING DOMAIN OF TRYPANOSOMA BRUCEI PEROXIN 5 (TBPEX5)COMPLEXED TO PTS1 PEPTIDE (10-SKL)
Descriptor:Peroxisome targeting signal 1 receptor PEX5, 10-SKL PTS1 peptide Ac-GTLSNRASKL
Authors:Sampathkumar, P., Roach, C., Michels, P.A.M., Hol, W.G.J.
Deposit date:2008-04-18
Release date:2008-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVQ
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STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING DOMAIN OF TRYPANOSOMA BRUCEI PEROXIN 5 (TBPEX5)COMPLEXED TO PTS1 PEPTIDE (7-SKL)
Descriptor:Peroxisome targeting signal 1 receptor PEX5, PTS1 peptide 7-SKL (Ac-SNRWSKL), GLYCEROL
Authors:Sampathkumar, P., Roach, C., Michels, P.A.M., Hol, W.G.J.
Deposit date:2008-04-18
Release date:2008-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
1EEF
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH BOUND LIGAND PEPG
Descriptor:PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN), ALPHA D-GALACTOSE, 2-PHENETHYL-2,3-DIHYDRO-PHTHALAZINE-1,4-DIONE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2000-01-31
Release date:2000-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
1EEI
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYL-ALPHA-D-GALACTOSE
Descriptor:PROTEIN (CHOLERA TOXIN B), METANITROPHENYL-ALPHA-D-GALACTOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2000-01-31
Release date:2000-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
1EFI
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH PARA-AMINOPHENYL-ALPHA-D-GALACTOPYRANOSIDE
Descriptor:PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN), 4'-AMINOPHENYL-ALPHA-D-GALACTOPYRANOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2000-02-08
Release date:2000-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
1FD7
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HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH BOUND LIGAND BMSC001
Descriptor:HEAT-LABILE ENTEROTOXIN B CHAIN, N-BENZYL-3-(ALPHA-D-GALACTOS-1-YL)-BENZAMIDE
Authors:Fan, E., Merritt, E.A., Pickens, J., Ahn, M., Hol, W.G.J.
Deposit date:2000-07-19
Release date:2000-08-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
1LT3
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HEAT-LABILE ENTEROTOXIN DOUBLE MUTANT N40C/G166C
Descriptor:HEAT-LABILE ENTEROTOXIN, BETA-D-GALACTOSE, BETA-D-GLUCOSE
Authors:Van Den Akker, F., Hol, W.G.J.
Deposit date:1997-04-12
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit.
Protein Sci., 6, 1997
2AUC
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STRUCTURE OF THE PLASMODIUM MTIP-MYOA COMPLEX, A KEY COMPONENT OF THE PARASITE INVASION MOTOR
Descriptor:Myosin A Tail Interacting Protein, Myosin A
Authors:Bosch, J., Turley, S., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-08-27
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2EPH
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CRYSTAL STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH TRAP-TAIL DETERMINED AT 2.7 ANGSTROM RESOLUTION
Descriptor:Fructose-bisphosphate aldolase, PbTRAP
Authors:Bosch, J., Buscaglia, C.A., Krumm, B., Cardozo, T., Nussenzweig, V., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-03-30
Release date:2007-04-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2PC4
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CRYSTAL STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH TRAP-TAIL DETERMINED AT 2.4 ANGSTROM RESOLUTION
Descriptor:Fructose-bisphosphate aldolase, PbTRAP
Authors:Bosch, J., Buscaglia, C.A., Krumm, B., Cardozo, T., Nussenzweig, V., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-03-29
Release date:2007-04-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
Proc.Natl.Acad.Sci.Usa, 104, 2007
4TR9
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TERNARY CO-CRYSTAL STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH TRAP AND A SMALL MOLECULE INHIBITOR
Descriptor:Fructose-bisphosphate aldolase, ALA-ALA-SER-LEU-TYR-GLU-LYS-LYS-ALA-ALA, ALA-ALA-ALA-SER-LEU-TYR-GLU-LYS-LYS-ALA-ALA, ...
Authors:Bosch, G., Weltzer, R., O'Malley, K., Bosch, J.
Deposit date:2014-06-15
Release date:2015-08-26
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (2.111 Å)
Cite:Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
Malar.J., 14, 2015