Author results

1UMP
  • Download 1ump
  • View 1ump
Molmil generated image of 1ump
GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, 2-AZASQUALENE
Authors:Reinert, D.J., Balliano, G., Schulz, G.E.
Deposit date:2003-08-27
Release date:2004-02-03
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Conversion of Squalene to the Pentacarbocyclic Hopene
Chem.Biol., 11, 2004
2BVL
  • Download 2bvl
  • View 2bvl
Molmil generated image of 2bvl
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF TOXIN B FROM CLOSTRIDIUM DIFFICILE IN COMPLEX WITH UDP, GLC AND MANGANESE ION
Descriptor:TOXIN B, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Reinert, D.J., Jank, T., Aktories, K., Schulz, G.E.
Deposit date:2005-06-30
Release date:2005-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
2BVM
  • Download 2bvm
  • View 2bvm
Molmil generated image of 2bvm
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF TOXIN B FROM CLOSTRIDIUM DIFFICILE IN COMPLEX WITH UDP, GLC AND MANGANESE ION
Descriptor:TOXIN B, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Reinert, D.J., Jank, T., Aktories, K., Schulz, G.E.
Deposit date:2005-06-30
Release date:2005-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
2CB4
  • Download 2cb4
  • View 2cb4
Molmil generated image of 2cb4
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE MOSQUITOCIDAL TOXIN FROM BACILLUS SPHAERICUS, MUTANT E197Q
Descriptor:MOSQUITOCIDAL TOXIN
Authors:Reinert, D.J., Carpusca, I., Aktories, K., Schulz, G.E.
Deposit date:2005-12-29
Release date:2006-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Mosquitocidal Toxin from Bacillus Sphaericus.
J.Mol.Biol., 357, 2006
2CB6
  • Download 2cb6
  • View 2cb6
Molmil generated image of 2cb6
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE MOSQUITOCIDAL TOXIN FROM BACILLUS SPHAERICUS, MUTANT E195Q
Descriptor:MOSQUITOCIDAL TOXIN
Authors:Reinert, D.J., Carpusca, I., Aktories, K., Schulz, G.E.
Deposit date:2005-12-29
Release date:2006-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Mosquitocidal Toxin from Bacillus Sphaericus.
J.Mol.Biol., 357, 2006
1H35
  • Download 1h35
  • View 1h35
Molmil generated image of 1h35
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (4'-{[ALLYL(METHYL)AMINO]METHYL}-1,1'-BIPHENYL-4-YL)(4-BROMOPHENYL)METHANONE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H36
  • Download 1h36
  • View 1h36
Molmil generated image of 1h36
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H37
  • Download 1h37
  • View 1h37
Molmil generated image of 1h37
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, {4-[((1S,2S)-2-{[ALLYL(CYCLOPROPYL)AMINO]METHYL}CYCLOPROPYL)METHOXY]PHENYL}(4-BROMOPHENYL)METHANONE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H39
  • Download 1h39
  • View 1h39
Molmil generated image of 1h39
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{6-[3-(4-BROMO-PHENYL)-1-METHYL-1H-INDAZOL-6-YL]OXY}HEXYL)-N-METHYLAMINE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3A
  • Download 1h3a
  • View 1h3a
Molmil generated image of 1h3a
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (2E)-N-ALLYL-4-{[3-(4-BROMOPHENYL)-5-FLUORO-1-METHYL-1H-INDAZOL-6-YL]OXY}-N-METHYL-2-BUTEN-1-AMINE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3B
  • Download 1h3b
  • View 1h3b
Molmil generated image of 1h3b
SQUALENE-HOPENE CYCLASE
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-{6-[4-(6-BROMO-1,2-BENZISOTHIAZOL-3-YL)PHENOXY]HEXYL}-N-METHYL-2-PROPEN-1-AMINE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-25
Release date:2003-08-21
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3C
  • Download 1h3c
  • View 1h3c
Molmil generated image of 1h3c
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-(6-{[3-(4-BROMOPHENYL)-1,2-BENZISOTHIAZOL-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-25
Release date:2003-08-21
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O6H
  • Download 1o6h
  • View 1o6h
Molmil generated image of 1o6h
SQUALENE-HOPENE CYCLASE
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-(6-{[1-(4-BROMOPHENYL)ISOQUINOLIN-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-10-03
Release date:2003-10-02
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O6Q
  • Download 1o6q
  • View 1o6q
Molmil generated image of 1o6q
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{4-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-BUT-2-ENYL}-METHYL-AMINE
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-10-13
Release date:2003-10-17
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O6R
  • Download 1o6r
  • View 1o6r
Molmil generated image of 1o6r
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{6-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-HEXYL-}-METHYL-AMIN
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-10-13
Release date:2003-10-17
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O79
  • Download 1o79
  • View 1o79
Molmil generated image of 1o79
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, METHYL-[4-(4-PIPERIDINE-1-YLMETHYL-PHENYL)-CYCLOHEXYL]-CARBAMINIC ACID-(4-CHLOROPHENYL)-ESTER
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-10-27
Release date:2003-10-23
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
2VSA
  • Download 2vsa
  • View 2vsa
Molmil generated image of 2vsa
STRUCTURE AND MODE OF ACTION OF A MOSQUITOCIDAL HOLOTOXIN
Descriptor:MOSQUITOCIDAL TOXIN
Authors:Treiber, N., Reinert, D.J., Carpusca, I., Aktories, K., Schulz, G.E.
Deposit date:2008-04-22
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure and Mode of Action of a Mosquitocidal Holotoxin
J.Mol.Biol., 381, 2008
2VSE
  • Download 2vse
  • View 2vse
Molmil generated image of 2vse
STRUCTURE AND MODE OF ACTION OF A MOSQUITOCIDAL HOLOTOXIN
Descriptor:MOSQUITOCIDAL TOXIN, (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL
Authors:Treiber, N., Reinert, D.J., Carpusca, I., Aktories, K., Schulz, G.E.
Deposit date:2008-04-22
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Mode of Action of a Mosquitocidal Holotoxin.
J.Mol.Biol., 381, 2008