1H39

Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme

Summary for 1H39

Entry DOI	10.2210/pdb1h39/pdb
Related	1GSZ 1H35 1H36 1H37 1H3A 1H3B 1H3C 1SQC 2SQC 3SQC
Descriptor	SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{6-[3-(4-BROMO-PHENYL)-1-METHYL-1H-INDAZOL-6-YL]OXY}HEXYL)-N-METHYLAMINE, ... (4 entities in total)
Functional Keywords	isomerase, cholesterol biosynthesis, inhibitor, monotopic membrane protein
Biological source	ALICYCLOBACILLUS ACIDOCALDARIUS
Total number of polymer chains	3
Total formula weight	217238.69
Authors	Lenhart, A.,Reinert, D.J.,Weihofen, W.A.,Aebi, J.D.,Dehmlow, H.,Morand, O.H.,Schulz, G.E. (deposition date: 2002-08-24, release date: 2003-08-21, Last modification date: 2018-06-13)
Primary citation	Lenhart, A.,Reinert, D.J.,Aebi, J.D.,Dehmlow, H.,Morand, O.H.,Schulz, G.E. Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase J.Med.Chem., 46:2083-, 2003 Cited by PubMed: 12747780 DOI: 10.1021/JM0211218 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation