Author results

2XIO
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STRUCTURE OF PUTATIVE DEOXYRIBONUCLEASE TATDN1 ISOFORM A
Descriptor:PUTATIVE DEOXYRIBONUCLEASE TATDN1, SODIUM ION, NICKEL (II) ION, ...
Authors:Muniz, J.R.C., Cocking, R., Puranik, S., Krojer, T., Raynor, J., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Yue, W.W., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-07-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Structure of Putative Deoxyribonuclease Tatdn1 Isoform A
To be Published
3RNJ
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN FROM IRSP53 (BAIAP2)
Descriptor:Brain-specific angiogenesis inhibitor 1-associated protein 2, {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID, 1,2-ETHANEDIOL, ...
Authors:Simister, P.C., Barilari, M., Muniz, J.R.C., Dente, L., Knapp, S., von Delft, F., Filippakopoulos, P., Vollmar, M., Chaikuad, A., Raynor, J., Tregubova, A., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Feller, S.M., Structural Genomics Consortium (SGC)
Deposit date:2011-04-22
Release date:2011-05-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the SH3 domain from IRSp53 (BAIAP2)
To be Published
4B9D
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CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1 (NEK1) WITH INHIBITOR.
Descriptor:SERINE/THREONINE-PROTEIN KINASE NEK1, [4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE, CHLORIDE ION, ...
Authors:Elkins, J.M., Hanchuk, T.D.M., Lovato, D.V., Basei, F.L., Meirelles, G.V., Kobarg, J., Szklarz, M., Vollmar, M., Mahajan, P., Rellos, P., Zhang, Y., Krojer, T., Pike, A.C.W., Canning, P., von Delft, F., Raynor, J., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2012-09-04
Release date:2012-09-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Nima-Related Kinase 1 (Nek1) with Inhibitor.
To be Published
4AZ9
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CRYSTAL STRUCTURE OF PHOX HOMOLOGY DOMAIN OF HUMAN SORTING NEXIN 24
Descriptor:SORTING NEXIN-24, 1,2-ETHANEDIOL
Authors:Oberholzer, A.E., Kiyani, W., Krojer, T., Shrestha, L., von Delft, F., Froese, D.S., Chaikuad, A., Raynor, J., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2012-06-24
Release date:2012-10-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Phox Homology Domain of Human Sorting Nexin 24
To be Published
4USD
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HUMAN STK10 (LOK) WITH SB-633825
Descriptor:SERINE/THREONINE-PROTEIN KINASE 10, 4-{5-(6-methoxynaphthalen-2-yl)-1-methyl-2-[2-methyl-4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl}pyridine
Authors:Elkins, J.M., Salah, E., Szklarz, M., von Delft, F., Canning, P., Raynor, J., Bountra, C., Edwards, A.M., Knapp, S.
Deposit date:2014-07-07
Release date:2015-07-22
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Comprehensive Characterization of the Published Kinase Inhibitor Set.
Nat.Biotechnol., 34, 2016
4USE
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HUMAN STK10 (LOK) WITH SB-633825
Descriptor:SERINE/THREONINE-PROTEIN KINASE 10, 4-{5-(6-methoxynaphthalen-2-yl)-1-methyl-2-[2-methyl-4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl}pyridine
Authors:Elkins, J.M., Salah, E., Szklarz, M., von Delft, F., Canning, P., Raynor, J., Bountra, C., Edwards, A.M., Knapp, S.
Deposit date:2014-07-07
Release date:2015-07-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Comprehensive Characterization of the Published Kinase Inhibitor Set.
Nat.Biotechnol., 34, 2016
2YD0
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CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Raynor, J., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2011-03-17
Release date:2011-04-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of the Endoplasmic Reticulum Aminopeptidase-1 (Erap1) Reveal the Molecular Basis for N-Terminal Peptide Trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q4T
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CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA (ACVR2A) KINASE DOMAIN IN COMPLEX WITH DORSOMORPHIN
Descriptor:Activin receptor type-2A, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, SULFATE ION, ...
Authors:Chaikuad, A., Alfano, I., Mahajan, P., Cooper, C.D.O., Sanvitale, C., Vollmar, M., Krojer, T., Muniz, J.R.C., Raynor, J., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-12-24
Release date:2011-02-09
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation.
J.Biol.Chem., 290, 2015
4C9W
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CRYSTAL STRUCTURE OF NUDT1 (MTH1) WITH R-CRIZOTINIB
Descriptor:7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, CHLORIDE ION, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, ...
Authors:Elkins, J.M., Salah, E., Huber, K., Superti-Furga, G., Abdul Azeez, K.R., Raynor, J., Krojer, T., von Delft, F., Bountra, C., Edwards, A., Knapp, S.
Deposit date:2013-10-03
Release date:2014-04-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy.
Nature, 508, 2014
3QNF
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CRYSTAL STRUCTURE OF THE OPEN STATE OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:Endoplasmic reticulum aminopeptidase 1, ZINC ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Harvey, D., Chaikuad, A., Allerston, C., Muniz, J.R.C., Raynor, J., Ugochukwu, E., Berridge, G., Wordsworth, B.P., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-02-08
Release date:2011-02-23
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011
4ASC
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KBTBD5
Descriptor:KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 5, 1,2-ETHANEDIOL
Authors:Canning, P., Ayinampudi, V., Krojer, T., Strain-Damerell, C., Raynor, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-04-30
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013