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1FJ4
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THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH THIOLACTOMYCIN, IMPLICATIONS FOR DRUG DESIGN
Descriptor:BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, THIOLACTOMYCIN
Authors:Price, A.C., Choi, K., Heath, R.J., Li, Z., White, S.W., Rock, C.O.
Deposit date:2000-08-07
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276, 2001
1FJ8
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THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN
Descriptor:BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE
Authors:Price, A.C., Choi, K., Heath, R.J., Li, Z., White, S.W., Rock, C.O.
Deposit date:2000-08-07
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276, 2001
1I01
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CRYSTAL STRUCTURE OF BETA-KETOACYL [ACYL CARRIER PROTEIN] REDUCTASE FROM E. COLI.
Descriptor:BETA-KETOACYL [ACP] REDUCTASE
Authors:Price, A.C., Rock, C.O., White, S.W.
Deposit date:2001-01-27
Release date:2001-02-07
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis.
Biochemistry, 40, 2001
1OX0
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THE CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE II FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
Authors:Price, A.C., Rock, C.O., White, S.W.
Deposit date:2003-03-31
Release date:2003-04-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
1OXH
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THE CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE II FROM STREPTOCOCCUS PNEUMONIAE, TRICLINIC FORM
Descriptor:Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
Authors:Price, A.C., Rock, C.O., White, S.W.
Deposit date:2003-04-02
Release date:2003-04-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
1Q7B
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THE STRUCTURE OF BETAKETOACYL-[ACP] REDUCTASE FROM E. COLI IN COMPLEX WITH NADP+
Descriptor:3-oxoacyl-[acyl-carrier protein] reductase, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Price, A.C., Zhang, Y.-M., Rock, C.O., White, S.M.
Deposit date:2003-08-17
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Cofactor-Induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a Proton Relay Conduit in FabG
Structure, 12, 2004
1Q7C
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THE STRUCTURE OF BETAKETOACYL-[ACP] REDUCTASE Y151F MUTANT IN COMPLEX WITH NADPH FRAGMENT
Descriptor:3-oxoacyl-[acyl-carrier protein] reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Price, A.C., Zhang, Y.-M., Rock, C.O., White, S.M.
Deposit date:2003-08-17
Release date:2004-02-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cofactor-Induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a Proton Relay Conduit in FabG
Structure, 12, 2004
1G5X
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THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I
Descriptor:BETA-KETOACYL ACYL CARRIER PROTEIN SYNTHASE I
Authors:Zhang, Y.M., Rao, M.S., Heath, R.J., Price, A.C., Olson, A.J., Rock, C.O., White, S.W.
Deposit date:2000-11-02
Release date:2000-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III.
J.Biol.Chem., 276, 2001
2AQ7
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STRUCTURE-ACTIVITY RELATIONSHIPS AT THE 5-POSIITON OF THIOLACTOMYCIN: AN INTACT 5(R)-ISOPRENE UNIT IS REQUIRED FOR ACTIVITY AGAINST THE CONDENSING ENZYMES FROM MYCOBACTERIUM TUBERCULOSIS AND ESCHERICHIA COLI
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE
Authors:Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J.
Deposit date:2005-08-17
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
2AQB
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STRUCTURE-ACTIVITY RELATIONSHIPS AT THE 5-POSITION OF THIOLACTOMYCIN: AN INTACT 5(R)-ISOPRENE UNIT IS REQUIRED FOR ACTIVITY AGAINST THE CONDENSING ENZYMES FROM MYCOBACTERIUM TUBERCULOSIS AND ESCHERCHIA COLI
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE
Authors:Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J.
Deposit date:2005-08-17
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
1Q32
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CRYSTAL STRUCTURE ANALYSIS OF THE YEAST TYROSYL-DNA PHOSPHODIESTERASE
Descriptor:tyrosyl-DNA phosphodiesterase
Authors:He, X., Babaoglu, K., Price, A., Nitiss, K.C., Nitiss, J.L., White, S.W.
Deposit date:2003-07-28
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison
J.Mol.Biol., 372, 2007