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3CBL
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CRYSTAL STRUCTURE OF HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES) IN COMPLEX WITH STAUROSPORINE AND A CONSENSUS PEPTIDE
Descriptor:Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, STAUROSPORINE
Authors:Filippakopoulos, P., Salah, E., Cooper, C., Picaud, S.S., Elkins, J.M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-02-22
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008
3CD3
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CRYSTAL STRUCTURE OF PHOSPHORYLATED HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES) IN COMPLEX WITH STAUROSPORINE AND A CONSENSUS PEPTIDE
Descriptor:Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, CHLORIDE ION, ...
Authors:Filippakopoulos, P., Salah, E., Cooper, C., Picaud, S.S., Elkins, J.M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-02-26
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008
3CEK
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CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITY PROTEIN KINASE (TTK)
Descriptor:Dual specificity protein kinase TTK, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Filippakopoulos, P., Soundararajan, M., Keates, T., Elkins, J.M., King, O., Fedorov, O., Picaud, S.S., Pike, A.C.W., Roos, A., Pilka, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-02-29
Release date:2008-03-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Nat.Chem.Biol., 6, 2010
3DA2
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X-RAY STRUCTURE OF HUMAN CARBONIC ANHYDRASE 13 IN COMPLEX WITH INHIBITOR
Descriptor:Carbonic anhydrase 13, ZINC ION, N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide, ...
Authors:Pilka, E.S., Picaud, S.S., Yue, W.W., King, O.N.F., Bray, J.E., Filippakopoulos, P., Roos, A.K., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Wikstrom, M., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-05-28
Release date:2008-07-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray structure of human carbonic anhydrase 13 in complex with inhibitor.
To be Published
2W2J
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CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE RELATED PROTEIN VIII
Descriptor:CARBONIC ANHYDRASE-RELATED PROTEIN, CHLORIDE ION, GLYCEROL, ...
Authors:Kramm, A., Muniz, J.R.C., Picaud, S.S., von Delft, F., Pilka, E.S., Yue, W.W., King, O.N.F., Kochan, G., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2008-10-31
Release date:2009-02-03
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Human Carbonic Anhydrase-Related Protein Viii Reveals the Basis for Catalytic Silencing.
Proteins, 76, 2009
3GFW
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CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITY PROTEIN KINASE (TTK) IN COMPLEX WITH A PYROLO-PYRIDIN LIGAND
Descriptor:Dual specificity protein kinase TTK, 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Filippakopoulos, P., Soundararajan, M., Choi, H., Keates, T., Elkins, J.M., King, O., Fedorov, O., Picaud, S.S., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Grey, N., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-02-27
Release date:2009-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Nat.Chem.Biol., 6, 2010
3H9F
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CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITY PROTEIN KINASE (TTK) IN COMPLEX WITH A PYRIMIDO-DIAZEPIN LIGAND
Descriptor:Dual specificity protein kinase TTK, MAGNESIUM ION, 9-cyclopentyl-2-(4-(4-hydroxypiperidin-1-yl)-2-methoxyphenylamino)-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one
Authors:Filippakopoulos, P., Soundararajan, M., Keates, T., Elkins, J.M., King, O., Fedorov, O., Picaud, S.S., Pike, A.C.W., Yue, W., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Kwiatkowski, N., Gray, N.S., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-04-30
Release date:2009-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Nat.Chem.Biol., 6, 2010
6G8R
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SP140 PHD-BROMODOMAIN COMPLEX WITH SCFV
Descriptor:short-chain variable fragment, Nuclear body protein SP140, 1,2-ETHANEDIOL, ...
Authors:Fairhead, M., Graslund, S., Strain-Damerell, C., Picaud, S.S., Pike, A.C.W., Pinkas, D.M., Wigren, E., Preger, C., Persson Lotsholm, H., Ossipova, E., Filippakopoulos, P., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2018-04-09
Release date:2018-04-18
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:SP140 PHD-Bromodomain complex with scFv
To Be Published