Author results

4DOJ
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CRYSTAL STRUCTURE OF BETP IN OUTWARD-FACING CONFORMATION
Descriptor:Glycine betaine transporter BetP, CHLORIDE ION, (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ...
Authors:Perez, C., Ziegler, C.
Deposit date:2012-02-09
Release date:2012-06-06
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP.
Nature, 490, 2012
3P03
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CRYSTAL STRUCTURE OF BETP-G153D WITH CHOLINE BOUND
Descriptor:Glycine betaine transporter BetP, CHOLINE ION
Authors:Perez, C., Ressl, S., Ziegler, Z.
Deposit date:2010-09-27
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Substrate specificity and ion coupling in the Na(+)/betaine symporter BetP.
Embo J., 30, 2011
4LLH
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SUBSTRATE BOUND OUTWARD-OPEN STATE OF THE SYMPORTER BETP
Descriptor:Glycine betaine transporter BetP, 2-(trimethyl-lambda~5~-arsanyl)ethanol, SODIUM ION, ...
Authors:Perez, C., Faust, B., Ziegler, C.
Deposit date:2013-07-09
Release date:2014-05-07
Last modified:2014-07-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na(+) coupling.
Nat Commun, 5, 2014
5C73
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ATP-DRIVEN LIPID-LINKED OLIGOSACCHARIDE FLIPPASE PGLK IN OUTWARD-OCCLUDED CONFORMATION
Descriptor:Protein glycosylation K
Authors:Perez, C., Locher, K.P.
Deposit date:2015-06-24
Release date:2015-08-19
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (5.9 Å)
Cite:Structure and mechanism of an active lipid-linked oligosaccharide flippase.
Nature, 524, 2015
5C76
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ATP-DRIVEN LIPID-LINKED OLIGOSACCHARIDE FLIPPASE PGLK IN APO-INWARD FACING STATE (2)
Descriptor:WlaB protein
Authors:Perez, C., Gerber, S., Locher, K.P.
Deposit date:2015-06-24
Release date:2015-08-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.94 Å)
Cite:Structure and mechanism of an active lipid-linked oligosaccharide flippase.
Nature, 524, 2015
5C78
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ATP-DRIVEN LIPID-LINKED OLIGOSACCHARIDE FLIPPASE PGLK IN APO-INWARD STATE (1)
Descriptor:ATP-driven flippase PglK, PENTAETHYLENE GLYCOL
Authors:Perez, C., Locher, K.P.
Deposit date:2015-06-24
Release date:2015-08-19
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and mechanism of an active lipid-linked oligosaccharide flippase.
Nature, 524, 2015
5NBD
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PGLK FLIPPASE IN COMPLEX WITH INHIBITORY NANOBODY
Descriptor:WlaB protein, Nanobody, ADENOSINE-5'-DIPHOSPHATE
Authors:Perez, C., Pardon, E., Steyaert, J., Locher, K.P.
Deposit date:2017-03-01
Release date:2017-05-03
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.
Sci Rep, 7, 2017
6HRC
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OUTWARD-FACING PGLK WITH ATPGAMMAS BOUND
Descriptor:WlaB protein, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Perez, C., Locher, K.P.
Deposit date:2018-09-26
Release date:2019-03-06
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of Outward-Facing PglK and Molecular Dynamics of Lipid-Linked Oligosaccharide Recognition and Translocation.
Structure, 27, 2019
1I6D
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SOLUTION STRUCTURE OF THE FUNCTIONAL DOMAIN OF PARACOCCUS DENITRIFICANS CYTOCHROME C552 IN THE REDUCED STATE
Descriptor:CYTOCHROME C552, HEME C
Authors:Reincke, B., Perez, C., Pristovsek, P., Luecke, C., Ludwig, C., Loehr, F., Rogov, V.V., Ludwig, B., Rueterjans, H.
Deposit date:2001-03-02
Release date:2001-10-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of the functional domain of Paracoccus denitrificans cytochrome c(552) in both redox states.
Biochemistry, 40, 2001
1I6E
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SOLUTION STRUCTURE OF THE FUNCTIONAL DOMAIN OF PARACOCCUS DENITRIFICANS CYTOCHROME C552 IN THE OXIDIZED STATE
Descriptor:CYTOCHROME C552, HEME C
Authors:Reincke, B., Perez, C., Pristovsek, P., Luecke, C., Ludwig, C., Loehr, F., Rogov, V.V., Ludwig, B., Rueterjans, H.
Deposit date:2001-03-02
Release date:2001-10-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of the functional domain of Paracoccus denitrificans cytochrome c(552) in both redox states.
Biochemistry, 40, 2001
1JBH
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SOLUTION STRUCTURE OF CELLULAR RETINOL BINDING PROTEIN TYPE-I IN THE LIGAND-FREE STATE
Descriptor:CELLULAR RETINOL-BINDING PROTEIN TYPE I
Authors:Franzoni, L., Luecke, C., Perez, C., Cavazzini, D., Rademacher, M., Ludwig, C., Spisni, A., Rossi, G.L., Rueterjans, H.
Deposit date:2001-06-04
Release date:2002-06-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution.
J.Biol.Chem., 277, 2002
1KGL
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SOLUTION STRUCTURE OF CELLULAR RETINOL BINDING PROTEIN TYPE-I IN COMPLEX WITH ALL-TRANS-RETINOL
Descriptor:CELLULAR RETINOL-BINDING PROTEIN TYPE I, RETINOL
Authors:Franzoni, L., Luecke, C., Perez, C., Cavazzini, D., Rademacher, M., Ludwig, C., Spisni, A., Rossi, G.L., Rueterjans, H.
Deposit date:2001-11-27
Release date:2002-06-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Backbone Dynamics of Apo- and Holo-cellular Retinol-binding Protein in Solution.
J.Biol.Chem., 277, 2002
2VBJ
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBL
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*DT*DC*DT*DG*DC*DC*DT*DT*DT*DT*DT*DT *DGP*DAP)-3', 5'-D(*DT*DT*DA*DG*DG*DA*DT*DC*DC*DT*DT*DC *DAP*DAP)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBN
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP)-3', 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBO
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
3GZG
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CRYSTAL STRUCTURE OF THE XANTHOMONAS AXONOPODIS PV. CITRI MOLYBDATE-BINDING PROTEIN (MODA) MUTANT (K127S)
Descriptor:Molybdate-binding periplasmic protein; permease, SULFATE ION, MOLYBDATE ION
Authors:Santacruz-Perez, C., Pegos, V.R., Balan, A., Barbosa, J.A.R.G.
Deposit date:2009-04-07
Release date:2009-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the Xanthomonas axonopodis pv. citri molybdate-binding protein (ModA) mutant (K127S)
To be Published
4AIN
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CRYSTAL STRUCTURE OF BETP WITH ASYMMETRIC PROTOMERS.
Descriptor:GLYCINE BETAINE TRANSPORTER BETP, SODIUM ION, TRIMETHYL GLYCINE, ...
Authors:Koshy, C., Ziegler, C., Yildiz, O.
Deposit date:2012-02-10
Release date:2012-06-06
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Alternating-Access Mechanism in Conformationally Asymmetric Trimers of the Betaine Transporter Betp.
Nature, 490, 2012
3G3N
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PDE7A CATALYTIC DOMAIN IN COMPLEX WITH 3-(2,6-DIFLUOROPHENYL)-2-(METHYLTHIO)QUINAZOLIN-4(3H)-ONE
Descriptor:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one, ZINC ION, ...
Authors:Castano, T., Wang, H.
Deposit date:2009-02-02
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors
Chemmedchem, 4, 2009
4C7R
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INWARD FACING CONFORMATION OF THE TRIMERIC BETAINE TRANSPORTER BETP IN COMPLEX WITH LIPIDS
Descriptor:GLYCINE BETAINE TRANSPORTER BETP, CITRATE ANION, CHLORIDE ION, ...
Authors:Koshy, C., Yildiz, O., Ziegler, C.
Deposit date:2013-09-24
Release date:2013-10-30
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Evidence for Functional Lipid Interactions in the Betaine Transporter Betp
Embo J., 32, 2013
6H0U
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GLYCOGEN SYNTHASE KINASE-3 BETA (GSK3) COMPLEX WITH A COVALENT [1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, (2~{R})-3-[7-azanyl-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl]-2-cyano-propanamide, MALONATE ION, ...
Authors:Marcovich, I., Demitri, N., De Zorzi, R., Storici, P.
Deposit date:2018-07-10
Release date:2019-05-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Triazolotriazine-Based Dual GSK-3 beta /CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition.
Chemmedchem, 14, 2019
1MX7
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TWO HOMOLOGOUS RAT CELLULAR RETINOL-BINDING PROTEINS DIFFER IN LOCAL STRUCTURE AND FLEXIBILITY
Descriptor:CELLULAR RETINOL-BINDING PROTEIN I, APO
Authors:Lu, J., Cistola, D.P., Li, E.
Deposit date:2002-10-01
Release date:2003-07-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Two Homologous Rat Cellular Retinol-binding Proteins Differ in Local Conformational Flexibility.
J.Mol.Biol., 330, 2003
1MX8
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TWO HOMOLOGOUS RAT CELLULAR RETINOL-BINDING PROTEINS DIFFER IN LOCAL STRUCTURE AND FLEXIBILITY
Descriptor:CELLULAR RETINOL-BINDING PROTEIN I, HOLO, RETINOL
Authors:Lu, J., Cistola, D.P., Li, E.
Deposit date:2002-10-01
Release date:2003-07-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility.
J.Mol.Biol., 330, 2003