Author results

2H8H
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SRC KINASE IN COMPLEX WITH A QUINAZOLINE INHIBITOR
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE
Authors:Otterbein, L.R., Norman, R., Pauptit, R.A., Rowsell, S., Breed, J.
Deposit date:2006-06-07
Release date:2006-11-21
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
J.Med.Chem., 49, 2006
5FXQ
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IGFR-1R COMPLEX WITH A PYRIMIDINE INHIBITOR.
Descriptor:INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine
Authors:Degorce, S., Boyd, S., Curwen, J., Ducray, R., Halsall, C., Jones, C., Lach, F., Lenz, E., Pass, M., Pass, S., Trigwell, C., Norman, R., Phillips, C.
Deposit date:2016-03-02
Release date:2016-10-19
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
J. Med. Chem., 59, 2016
5FXR
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IGFR-1R COMPLEX WITH A PYRIMIDINE INHIBITOR.
Descriptor:INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine
Authors:Degorce, S., Boyd, S., Curwen, J., Ducray, R., Halsall, C., Jones, C., Lach, F., Lenz, E., Pass, M., Pass, S., Trigwell, C., Norman, R., Phillips, C.
Deposit date:2016-03-02
Release date:2016-10-19
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
J. Med. Chem., 59, 2016
5FXS
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IGFR-1R COMPLEX WITH A PYRIMIDINE INHIBITOR.
Descriptor:INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, ACETATE ION, 2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide
Authors:Degorce, S., Boyd, S., Curwen, J., Ducray, R., Halsall, C., Jones, C., Lach, F., Lenz, E., Pass, M., Pass, S., Trigwell, C., Norman, R., Phillips, C.
Deposit date:2016-03-02
Release date:2016-10-19
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
J. Med. Chem., 59, 2016
2WQB
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STRUCTURE OF THE TIE2 KINASE DOMAIN IN COMPLEX WITH A THIAZOLOPYRIMIDINE INHIBITOR
Descriptor:ANGIOPOIETIN-1 RECEPTOR, 2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE
Authors:Brassington, C., Breed, J., Buttar, D., Fitzek, M., Forder, C., Hassall, L., Hayter, B.R., Jones, C.D., Luke, R.W.A., McCall, E., McCoull, W., Norman, R., Paterson, D., McMiken, H., Rowsell, S., Tucker, J.A.
Deposit date:2009-08-18
Release date:2009-11-03
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Novel Thienopyrimidine and Thiazolopyrimidine Kinase Inhibitors with Activity Against Tie-2 in Vitro and in Vivo.
Bioorg.Med.Chem.Lett., 19, 2009