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6K9V
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CRYSTAL STRUCTURE OF TUBULIN IN COMPLEX WITH INHIBITOR D64
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Yu, Y., Chen, Q.
登録日2019-06-18
公開日2019-08-28
実験手法X-RAY DIFFRACTION (2.543 Å)
主引用文献Structural insights into the design of indole derivatives as tubulin polymerization inhibitors.
Febs Lett., 2019
6J71
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HUA21-SCFV IN COMPLEX WITH THE EXTRACELLULAR DOMAIN(ECD) OF HER2
分子名称:Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, BETA-D-MANNOSE, ...
著者Wang, Z., Guo, G., Cheng, B., Zhu, Z., Niu, L., Zhang, H.
登録日2019-01-16
公開日2019-02-27
最終更新日2019-06-26
実験手法X-RAY DIFFRACTION (2.918 Å)
主引用文献Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells.
Acta Crystallogr D Struct Biol, 75, 2019
6J3O
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CRYSTAL STRUCTURE OF THE HUMAN PCAF BROMODOMAIN IN COMPLEX WITH COMPOUND 12
分子名称:Histone acetyltransferase KAT2B, 3-methyl-2-[[(3~{R})-1-methylpiperidin-3-yl]amino]-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one
著者Huang, L.Y., Li, H., Li, L.L., Niu, L., Seupel, R., Wu, C.Y., Li, G.B., Yu, Y.M., Brennan, P.E., Yang, S.Y.
登録日2019-01-05
公開日2019-05-01
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
J.Med.Chem., 62, 2019
6J3P
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CRYSTAL STRUCTURE OF THE HUMAN GCN5 BROMODOMAIN IN COMPLEX WITH COMPOUND (R,R)-36N
分子名称:Histone acetyltransferase KAT2A, 2-{[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylpiperidin-3-yl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
著者Huang, L.Y., Li, H., Niu, L., Wu, C.Y., Yu, Y.M., Li, L.L., Yang, S.Y.
登録日2019-01-05
公開日2019-05-01
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (1.598 Å)
主引用文献Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
J.Med.Chem., 62, 2019
6IEX
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CRYSTAL STRUCTURE OF HLA-B*4001 IN COMPLEX WITH SARS-COV DERIVED PEPTIDE N216-225 GETALALLLL
分子名称:MHC class I antigen, Beta-2-microglobulin, GLY-GLU-THR-ALA-LEU-ALA-LEU-LEU-LEU-LEU
著者Ji, W., Niu, L., Peng, W., Zhang, Y., Shi, Y., Qi, J., Gao, G.F., Liu, W.J.
登録日2018-09-17
公開日2019-09-18
実験手法X-RAY DIFFRACTION (2.314 Å)
主引用文献crystal structure of HLA-B*4001 in complex with SARS-derived peptide N216-225 GETALALLLL
To Be Published
6AIK
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CAB2 MUTANT H337A COMPLEX WITH PHOSPHOPANTOTHENOYL-CMP
分子名称:Phosphopantothenate--cysteine ligase CAB2, PHOSPHORIC ACID MONO-[3-(3-{[5-(4-AMINO-2-OXO-2H-PYRIMIDIN-1-YL)-3,4- DIHYDROXY-TETRAHYDRO-FURAN-2- YLMETHOXY]-HYDROXY-PHOSPHORYLOXY}-3-OXO-PROPYLCARBAMOYL)-3-HYDROXY-2,2- DIMETHYL-PROPYL] ESTER
著者Zheng, P., Zhu, Z.
登録日2018-08-24
公開日2019-03-20
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
J. Mol. Biol., 431, 2019
6AIM
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CAB2 MUTANT H337A COMPLEX WITH PHOSPHOPANTOTHENATE-CYSTEINE
分子名称:Phosphopantothenate--cysteine ligase CAB2, N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl-L-cysteine
著者Zheng, P., Zhu, Z.
登録日2018-08-24
公開日2019-03-20
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
J. Mol. Biol., 431, 2019
6AIP
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CAB2 MUTANT-H337A COMPLEX WITH PHOSPHOPANTOTHENOYLCYSTINE
分子名称:Phosphopantothenate--cysteine ligase CAB2, (5R,12R,17R)-17-amino-12-carboxy-1,1,5-trihydroxy-4,4-dimethyl-6,10-dioxo-2-oxa-14,15-dithia-7,11-diaza-1-phosphaoctadecan-18-oic acid 1-oxide (non-preferred name)
著者Zheng, P., Zhu, Z.
登録日2018-08-24
公開日2019-03-20
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
J. Mol. Biol., 431, 2019
6AI8
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CAB2 MUTANT-H337A
分子名称:Phosphopantothenate--cysteine ligase CAB2, GLYCEROL, SULFATE ION
著者Zheng, P., Zhu, Z.
登録日2018-08-22
公開日2019-03-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
J. Mol. Biol., 431, 2019
6AI9
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CAB2 MUTANT-H337A COMPLEX WITH PHOSPHOPANTOTHENATE
分子名称:Phosphopantothenate--cysteine ligase CAB2, N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanine
著者Zheng, P., Zhu, Z.
登録日2018-08-22
公開日2019-03-20
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
J. Mol. Biol., 431, 2019
6FWB
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CRYSTAL STRUCTURE OF MAT2A AT 1.79 ANGSTRON RESOLUTION
分子名称:S-adenosylmethionine synthase isoform type-2, SULFATE ION, TETRAETHYLENE GLYCOL, ...
著者Zhou, A., Wei, Z., Bai, J., Wang, H.
登録日2018-03-06
公開日2019-03-27
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Ebiomedicine, 39, 2019
5YMV
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CRYSTAL STRUCTURE OF 9-MER PEPTIDE FROM INFLUENZA VIRUS IN COMPLEX WITH BF2*1201
分子名称:Class I histocompatibility antigen, F10 alpha chain, Beta-2-microglobulin, ...
著者Xiao, J., Xiang, W., Qi, J., Chai, Y., Liu, W.J., Gao, G.F.
登録日2017-10-22
公開日2018-10-24
最終更新日2019-07-31
実験手法X-RAY DIFFRACTION (2.197 Å)
主引用文献An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.
J Immunol., 201, 2018
5YMW
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CRYSTAL STRUCTURE OF 8-MER PEPTIDE FROM ROUS SARCOMA VIRUS IN COMPLEX WITH BF2*1201
分子名称:Class I histocompatibility antigen, F10 alpha chain, Beta-2-microglobulin, ...
著者Xiao, J., Xiang, W., Qi, J., Chai, Y., Liu, W.J., Gao, G.F.
登録日2017-10-22
公開日2018-10-24
最終更新日2019-07-31
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.
J Immunol., 201, 2018
5XLT
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THE CRYSTAL STRUCTURE OF TUBULIN IN COMPLEX WITH 4'-DEMETHYLEPIPODOPHYLLOTOXIN
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Yu, Y., Chen, Q.
登録日2017-05-11
公開日2017-09-27
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.813 Å)
主引用文献Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
Biochem. Biophys. Res. Commun., 493, 2017
5H4Y
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CRYSTAL STRUCTURE OF HUMAN SYNAPTOTAGMIN 5 C2A DOMAIN
分子名称:Synaptotagmin-5, CALCIUM ION, ACETATE ION
著者Qiu, X., Gao, Y., Teng, M., Niu, L.
登録日2016-11-02
公開日2016-11-30
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of Ca(2+)-binding pocket of synaptotagmin 5 C2A domain
Int. J. Biol. Macromol., 95, 2017
5H4Z
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CRYSTAL STRUCTURE OF S202G MUTANT OF HUMAN SYT-5 C2A DOMAIN
分子名称:Synaptotagmin-5, CALCIUM ION, CHLORIDE ION
著者Qiu, X., Ge, J., Yan, X., Gao, Y., Teng, M., Niu, L.
登録日2016-11-02
公開日2016-11-30
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural analysis of Ca(2+)-binding pocket of synaptotagmin 5 C2A domain
Int. J. Biol. Macromol., 95, 2017
5J08
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CRYSTAL STRUCTURE OF YEAST ENT5 N-TERMINAL DOMAIN-NATIVE P21
分子名称:Epsin-5
著者Zhang, F., Song, Y., Li, X., Teng, M.K.
登録日2016-03-28
公開日2016-10-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional insight into the N-terminal domain of the clathrin adaptor Ent5 from Saccharomyces cerevisiae
Biochem.Biophys.Res.Commun., 477, 2016
5I39
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HIGH RESOLUTION STRUCTURE OF L-AMINO ACID DEAMINASE FROM PROTEUS VULGARIS WITH THE DELETION OF THE SPECIFIC INSERTION SEQUENCE
分子名称:L-amino acid deaminase, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL
著者Zhou, H., Ju, Y., Niu, L., Teng, M.
登録日2016-02-10
公開日2016-08-03
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris
J.Struct.Biol., 195, 2016
5HXW
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L-AMINO ACID DEAMINASE FROM PROTEUS VULGARIS
分子名称:L-amino acid deaminase, FLAVIN-ADENINE DINUCLEOTIDE, CETYL-TRIMETHYL-AMMONIUM
著者Zhou, H., Ju, Y., Niu, L., Teng, M.
登録日2016-01-31
公開日2016-08-03
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris
J.Struct.Biol., 195, 2016
5ERG
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CRYSTAL STRUCTURE OF THE TWO-SUBUNIT TRNA M1A58 METHYLTRANSFERASE TRM6-TRM61 IN COMPLEX WITH SAM
分子名称:tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, S-ADENOSYLMETHIONINE
著者Zhu, Y., Wang, M., Wang, C., Fan, X., Jiang, X., Teng, M., Li, X.
登録日2015-11-14
公開日2016-09-14
実験手法X-RAY DIFFRACTION (2.202 Å)
主引用文献Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
Sci Rep, 6, 2016
5EQJ
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CRYSTAL STRUCTURE OF THE TWO-SUBUNIT TRNA M1A58 METHYLTRANSFERASE FROM SACCHAROMYCES CEREVISIAE
分子名称:tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61
著者Zhu, Y., Wang, M., Wang, C., Fan, X., Jiang, X., Teng, M., Li, X.
登録日2015-11-13
公開日2016-09-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
Sci Rep, 6, 2016
5DIK
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CRYSTAL STRUCTURE OF APO-LPG0406, A CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN FROM LEGIONELLA PNEUMOPHILA
分子名称:Alkyl hydroperoxide reductase AhpD
著者Chen, X., Gong, X., Zhang, N., Ge, H.
登録日2015-09-01
公開日2015-10-14
最終更新日2016-01-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila
Protein Sci., 24, 2015
5DIP
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CRYSTAL STRUCTURE OF LPG0406 IN REDUCED FORM FROM LEGIONELLA PNEUMOPHILA
分子名称:Alkyl hydroperoxide reductase AhpD, SODIUM ION, GLYCEROL
著者Chen, X., Gong, X., Zhang, N., Ge, H.
登録日2015-09-01
公開日2015-10-14
最終更新日2016-01-27
実験手法X-RAY DIFFRACTION (2.097 Å)
主引用文献Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila
Protein Sci., 24, 2015
5DDZ
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CRYSTAL STRUCTURE OF THE RTA-C10-P2 COMPLEX
分子名称:Ricin, 60S acidic ribosomal protein P2
著者Zhu, Y., Fan, X., Wang, C., Niu, L., Li, X., Teng, M.
登録日2015-08-25
公開日2016-09-07
最終更新日2016-12-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural insights into the interaction of the ribosomal P stalk protein P2 with a type II ribosome-inactivating protein ricin
Sci Rep, 6, 2016
5CMW
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CRYSTAL STRUCTURE OF YEAST ENT5 N-TERMINAL DOMAIN-SOAKED IN KI
分子名称:Epsin-5, GLYCEROL, IODIDE ION
著者Zhang, F., Song, Y., Li, X., Teng, M.K.
登録日2015-07-17
公開日2016-07-20
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and functional insight into the N-terminal domain of the clathrin adaptor Ent5 from Saccharomyces cerevisiae
Biochem.Biophys.Res.Commun., 477, 2016