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6C4G
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PLASMEPSIN V FROM PLASMODIUM VIVAX BOUND TO A TRANSITION STATE MIMETIC (WEHI-601)
Descriptor:Aspartic protease PM5, N-ACETYL-D-GLUCOSAMINE, benzyl [(6S,7S,10S,13S,18Z)-18-amino-10-cyclohexyl-6-hydroxy-18-imino-7-(2-methylpropyl)-4,9,12-trioxo-1-phenyl-16-oxa-3,8,11,17-tetraazaoctadecan-13-yl]carbamate, ...
Authors:Czabotar, P.E., Hodder, A.N., Nguyen, W., Sleebs, B.E., Boddey, J.A., Cowman, A.F.
Deposit date:2018-01-11
Release date:2018-06-13
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2position of PEXEL peptidomimetics.
Eur J Med Chem, 154, 2018