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1A0H
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THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN
Descriptor:MEIZOTHROMBIN, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, N-ACETYL-D-GLUCOSAMINE
Authors:Martin, P.D., Malkowski, M.G., Box, J., Esmon, C.T., Edwards, B.F.P.
Deposit date:1997-11-30
Release date:1998-06-17
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.
Structure, 5, 1997
1SRN
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THE REFINED CRYSTAL STRUCTURE OF A FULLY ACTIVE SEMISYNTHETIC RIBONUCLEASE AT 1.8 ANGSTROMS RESOLUTION
Descriptor:RIBONUCLEASE A, SULFATE ION
Authors:Martin, P.D., Doscher, M.S., Edwards, B.F.P.
Deposit date:1990-10-05
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The refined crystal structure of a fully active semisynthetic ribonuclease at 1.8-A resolution.
J.Biol.Chem., 262, 1987
1XRF
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THE CRYSTAL STRUCTURE OF A NOVEL, LATENT DIHYDROOROTASE FROM AQUIFEX AEOLICUS AT 1.7 A RESOLUTION
Descriptor:Dihydroorotase, ZINC ION, SULFATE ION
Authors:Martin, P.D., Purcarea, C., Zhang, P., Vaishnav, A., Sadecki, S., Guy-Evans, H.I., Evans, D.R., Edwards, B.F.
Deposit date:2004-10-14
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of a novel, latent dihydroorotase from Aquifex aeolicus at 1.7A resolution
J.Mol.Biol., 348, 2005
1XRT
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THE CRYSTAL STRUCTURE OF A NOVEL, LATENT DIHYDROOROTASE FROM AQUIFEX AEOLICUS AT 1.7 A RESOLUTION
Descriptor:Dihydroorotase, ZINC ION
Authors:Martin, P.D., Purcarea, C., Zhang, P., Vaishnav, A., Sadecki, S., Guy-Evans, H.I., Evans, D.R., Edwards, B.F.
Deposit date:2004-10-15
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.609 Å)
Cite:The crystal structure of a novel, latent dihydroorotase from Aquifex aeolicus at 1.7A resolution
J.Mol.Biol., 348, 2005
1SSC
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THE 1.6 ANGSTROMS STRUCTURE OF A SEMISYNTHETIC RIBONUCLEASE CRYSTALLIZED FROM AQUEOUS ETHANOL. COMPARISON WITH CRYSTALS FROM SALT SOLUTIONS AND WITH RNASE A FROM AQUEOUS ALCOHOL SOLUTIONS
Descriptor:RIBONUCLEASE A, PHOSPHATE ION
Authors:De Mel, V.S.J., Doscher, M.S., Martin, P.D., Rodier, F., Edwards, B.F.P.
Deposit date:1994-10-05
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:1.6 A structure of semisynthetic ribonuclease crystallized from aqueous ethanol. Comparison with crystals from salt solutions and with ribonuclease A from aqueous alcohol solutions.
Acta Crystallogr.,Sect.D, 51, 1995
1SSA
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A STRUCTURAL INVESTIGATION OF CATALYTICALLY MODIFIED F12OL AND F12OY SEMISYNTHETIC RIBONUCLEASES
Descriptor:RIBONUCLEASE A, SULFATE ION
Authors:deMel, V.S.J., Doscher, M.S., Glinn, M.A., Martin, P.D., Ram, M.L., Edwards, B.F.P.
Deposit date:1993-08-03
Release date:1994-09-30
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural investigation of catalytically modified F120L and F120Y semisynthetic ribonucleases.
Protein Sci., 3, 1994
1SSB
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A STRUCTURAL INVESTIGATION OF CATALYTICALLY MODIFIED F12OL AND F12OY SEMISYNTHETIC RIBONUCLEASES
Descriptor:RIBONUCLEASE A, SULFATE ION
Authors:Demel, V.S.J., Doscher, M.S., Glinn, M.A., Martin, P.D., Ram, M.L., Edwards, B.F.P.
Deposit date:1993-08-03
Release date:1994-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural investigation of catalytically modified F120L and F120Y semisynthetic ribonucleases.
Protein Sci., 3, 1994
4BJH
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CRYSTAL STRUCTURE OF THE AQUIFEX REACTOR COMPLEX FORMED BY DIHYDROOROTASE (H180A, H232A) WITH DIHYDROOROTATE AND ASPARTATE TRANSCARBAMOYLASE WITH N-(PHOSPHONACETYL)-L-ASPARTATE (PALA)
Descriptor:DIHYDROOROTASE, ASPARTATE CARBAMOYLTRANSFERASE, ZINC ION, ...
Authors:Edwards, B.F.P., Martin, P.D., Grimley, E., Vaishnav, A., Fernando, R., Brunzelle, J.S., Cordes, M., Evans, H.G., Evans, D.R.
Deposit date:2013-04-18
Release date:2013-12-18
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Mononuclear Metal Center of Type-I Dihydroorotase from Aquifex Aeolicus.
Bmc Biochem., 14, 2013
2RVE
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THE CRYSTAL STRUCTURE OF ECORV ENDONUCLEASE AND OF ITS COMPLEXES WITH COGNATE AND NON-COGNATE DNA SEGMENTS
Descriptor:DNA (5'-D(*CP*GP*AP*GP*CP*TP*CP*G)-3'), PROTEIN (ECO RV (E.C.3.1.21.4))
Authors:Winkler, F.K., Banner, D.W., Oefner, C., Tsernoglou, D., Brown, R.S., Heathman, S.P., Bryan, R.K., Martin, P.D., Petratos, K., Wilson, K.S.
Deposit date:1991-03-19
Release date:1992-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments.
EMBO J., 12, 1993
3OQ7
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CRYSTAL STRUCTURES OF MULTIDRUG-RESISTANT CLINICAL ISOLATE 769 HIV-1 PROTEASE VARIANTS
Descriptor:HIV-1 Protease
Authors:Yedidi, R.S., Proteasa, G., Martinez-Cajas, J.L., Vickrey, J.F., Martin, P.D., Wawrzak, Z., Kovari, L.C.
Deposit date:2010-09-02
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
3OQA
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CRYSTAL STRUCTURES OF MULTIDRUG-RESISTANT CLINICAL ISOLATE 769 HIV-1 PROTEASE VARIANTS
Descriptor:HIV-1 Protease
Authors:Yedidi, R.S., Proteasa, G., Martinez-Cajas, J.L., Vickrey, J.F., Martin, P.D., Wawrzak, Z., Kovari, L.C.
Deposit date:2010-09-02
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
3OQD
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CRYSTAL STRUCTURES OF MULTIDRUG-RESISTANT CLINICAL ISOLATE 769 HIV-1 PROTEASE VARIANTS
Descriptor:HIV-1 Protease
Authors:Yedidi, R.S., Proteasa, G., Martinez-Cajas, J.L., Vickrey, J.F., Martin, P.D., Wawrzak, Z., Kovari, L.C.
Deposit date:2010-09-02
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
3PJ6
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CRYSTAL STRUCTURES OF MULTIDRUG-RESISTANT CLINICAL ISOLATE 769 HIV-1 PROTEASE VARIANTS
Descriptor:HIV protease
Authors:Yedidi, R.S., Proteasa, G., Martinez-Cajas, J.L., Vickrey, J.F., Martin, P.D., Wawrzak, Z., Kovari, L.C.
Deposit date:2010-11-08
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
3SRN
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STRUCTURAL CHANGES THAT ACCOMPANY THE REDUCED CATALYTIC EFFICIENCY OF TWO SEMISYNTHETIC RIBONUCLEASE ANALOGS
Descriptor:RIBONUCLEASE A, SULFATE ION
Authors:deMel, V.S.J., Martin, P.D., Doscher, M.S., Edwards, B.F.P.
Deposit date:1991-05-20
Release date:1994-12-20
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural changes that accompany the reduced catalytic efficiency of two semisynthetic ribonuclease analogs.
J.Biol.Chem., 267, 1992
4RVE
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THE CRYSTAL STRUCTURE OF ECORV ENDONUCLEASE AND OF ITS COMPLEXES WITH COGNATE AND NON-COGNATE DNA SEGMENTS
Descriptor:DNA (5'-D(*GP*GP*GP*AP*TP*AP*TP*CP*CP*C)-3'), PROTEIN (ECO RV (E.C.3.1.21.4))
Authors:Winkler, F.K., Banner, D.W., Oefner, C., Tsernoglou, D., Brown, R.S., Heathman, S.P., Bryan, R.K., Martin, P.D., Petratos, K., Wilso, K.S.
Deposit date:1993-02-18
Release date:1993-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments.
EMBO J., 12, 1993
4SRN
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STRUCTURAL CHANGES THAT ACCOMPANY THE REDUCED CATALYTIC EFFICIENCY OF TWO SEMISYNTHETIC RIBONUCLEASE ANALOGS
Descriptor:RIBONUCLEASE A, SULFATE ION
Authors:deMel, V.S.J., Martin, P.D., Doscher, M.S., Edwards, B.F.P.
Deposit date:1991-05-20
Release date:1994-12-20
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural changes that accompany the reduced catalytic efficiency of two semisynthetic ribonuclease analogs.
J.Biol.Chem., 267, 1992
1BBR
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THE STRUCTURE OF RESIDUES 7-16 OF THE A ALPHA CHAIN OF HUMAN FIBRINOGEN BOUND TO BOVINE THROMBIN AT 2.3 ANGSTROMS RESOLUTION
Descriptor:EPSILON-THROMBIN, FIBRINOGEN ALPHA/ALPHA-E CHAIN PRECURSOR
Authors:Martin, P., Edwards, B.
Deposit date:1992-04-27
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
J.Biol.Chem., 267, 1992
1UCY
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THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A ALPHA (RESIDUES 7-19). THREE COMPLEXES, ONE WITH EPSILON-THROMBIN AND TWO WITH ALPHA-THROMBIN
Descriptor:THROMBIN, FIBRINOPEPTIDE A-ALPHA
Authors:Martin, P., Edwards, B.
Deposit date:1996-08-30
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues.
Biochemistry, 35, 1996
1MKW
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor:ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1MKX
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor:ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1YCP
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THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16
Descriptor:EPSILON THROMBIN, ALPHA THROMBIN, FIBRINOPEPTIDE A-ALPHA
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-05-01
Release date:1998-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Biochem.J., 326, 1997
1AZ0
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ECORV ENDONUCLEASE/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3'), PROTEIN (TYPE II RESTRICTION ENZYME ECORV), CALCIUM ION
Authors:Perona, J.J., Martin, A.M.
Deposit date:1997-11-24
Release date:1998-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational transitions and structural deformability of EcoRV endonuclease revealed by crystallographic analysis.
J.Mol.Biol., 273, 1997
1AZ3
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ECORV ENDONUCLEASE, UNLIGANDED, FORM B
Descriptor:ECORV ENDONUCLEASE
Authors:Perona, J., Martin, A.
Deposit date:1997-11-24
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational transitions and structural deformability of EcoRV endonuclease revealed by crystallographic analysis.
J.Mol.Biol., 273, 1997
1AZ4
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ECORV ENDONUCLEASE, UNLIGANDED, FORM B, T93A MUTANT
Descriptor:ECORV ENDONUCLEASE
Authors:Perona, J., Martin, A.
Deposit date:1997-11-24
Release date:1998-05-27
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational transitions and structural deformability of EcoRV endonuclease revealed by crystallographic analysis.
J.Mol.Biol., 273, 1997
1ETR
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REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS
Descriptor:EPSILON-THROMBIN, amino{[(4S)-5-[(2R,4R)-2-carboxy-4-methylpiperidin-1-yl]-4-({[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}amino)-5-oxopentyl]amino}methaniminium
Authors:Bode, W., Brandstetter, H.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
J.Mol.Biol., 226, 1992
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