Author results

1TW7
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WIDE OPEN 1.3A STRUCTURE OF A MULTI-DRUG RESISTANT HIV-1 PROTEASE REPRESENTS A NOVEL DRUG TARGET
Descriptor:protease, SODIUM ION
Authors:Martin, P., Vickrey, J.F., Proteasa, G., Jimenez, Y.L., Wawrzak, Z., Winters, M.A., Merigan, T.C., Kovari, L.C.
Deposit date:2004-06-30
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target
Structure, 13, 2005
1I9D
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ARSENATE REDUCTASE FROM E. COLI
Descriptor:ARSENATE REDUCTASE, SULFATE ION, SULFITE ION, ...
Authors:Martin, P., Edwards, B.F.
Deposit date:2001-03-19
Release date:2001-12-05
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme.
Structure, 9, 2001
1J9B
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ARSENATE REDUCTASE+0.4M ARSENITE FROM E. COLI
Descriptor:ARSENATE REDUCTASE, SULFATE ION, CESIUM ION, ...
Authors:Martin, P., Edwards, B.F.
Deposit date:2001-05-24
Release date:2001-12-05
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme.
Structure, 9, 2001
1JZW
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ARSENATE REDUCTASE + SODIUM ARSENATE FROM E. COLI
Descriptor:ARSENATE REDUCTASE, SULFATE ION, SULFITE ION, ...
Authors:Martin, P., DeMel, S., Shi, J., Gladysheva, T., Gatti, D.L., Rosen, B.P., Edwards, B.F.
Deposit date:2001-09-17
Release date:2001-11-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme.
Structure, 9, 2001
1BAV
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CARBOXYPEPTIDASE A COMPLEXED WITH 2-BENZYL-3-IODO-PROPANOIC ACID (BIP)
Descriptor:CARBOXYPEPTIDASE A, ZINC ION, 2-BENZYL-3-IODOPROPANOIC ACID
Authors:Martin, P., Edwards, B.
Deposit date:1996-11-14
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic and computational insight on the mechanism of zinc-ion-dependent inactivation of carboxypeptidase a by 2-benzyl-3-iodopropanoate.
J.Am.Chem.Soc., 118, 1996
2EF9
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STRUCTURAL AND MECHANISTIC CHANGES ALONG AN ENGINEERED PATH FROM METALLO TO NON-METALLO KDO8P SYNTHASE
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE, ARABINOSE-5-PHOSPHATE
Authors:Kona, F., Xu, X., Martin, P., Kuzmic, P., Gatti, D.L.
Deposit date:2007-02-22
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases
Biochemistry, 46, 2007
2NWR
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CRYSTAL STRUCTURE OF C11N MUTANT OF KDO8P SYNTHASE IN COMPLEX WITH PEP
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHATE ION, PHOSPHOENOLPYRUVATE
Authors:Kona, F., Xu, X., Martin, P., Kuzmic, P., Gatti, D.L.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
2NWS
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STRUCTURAL AND MECHANISTIC CHANGES ALONG AN ENGINEERED PATH FROM METALLO TO NON-METALLO KDO8P SYNTHASE
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE, ARABINOSE-5-PHOSPHATE
Authors:Kona, F., Xu, X., Martin, P., Kuzmic, P., Gatti, D.L.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
2NX1
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STRUCTURAL AND MECHANISTIC CHANGES ALONG AN ENGINEERED PATH FROM METALLO TO NON-METALLO KDO8P SYNTHASE
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, 5-O-phosphono-beta-D-ribofuranose, PHOSPHOENOLPYRUVATE
Authors:Kona, F., Xu, X., Martin, P., Kuzmic, P., Gatti, D.L.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
2NX3
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STRUCTURAL AND MECHANISTIC CHANGES ALONG AN ENGINEERED PATH FROM METALLO TO NON-METALLO KDO8P SYNTHASE
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE, ARABINOSE-5-PHOSPHATE, ...
Authors:Kona, F., Xu, X., Martin, P., Kuzmic, P., Gatti, D.L.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
2NXG
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STRUCTURAL AND MECHANISTIC CHANGES ALONG AN ENGINEERED PATH FROM METALLO TO NON-METALLO KDO8P SYNTHASE.
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE, ARABINOSE-5-PHOSPHATE, ...
Authors:Kona, F., Xu, X., Martin, P., Kuzmic, P., Gatti, D.L.
Deposit date:2006-11-17
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
2NXH
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STRUCTURAL AND MECHANISTIC CHANGES ALONG AN ENGINEERED PATH FROM METALLO TO NON-METALLO KDO8P SYNTHASE.
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHATE ION, PHOSPHOENOLPYRUVATE
Authors:Kona, F., Xu, X., Martin, P., Kuzmic, P., Gatti, D.L.
Deposit date:2006-11-17
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
2NXI
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STRUCTURAL AND MECHANISTIC CHANGES ALONG AN ENGINEERED PATH FROM METALLO TO NON-METALLO KDO8P SYNTHASE.
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHATE ION, PHOSPHOENOLPYRUVATE
Authors:Kona, F., Xu, X., Martin, P., Kuzmic, P., Gatti, D.L.
Deposit date:2006-11-17
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and mechanistic changes along an engineered path from metallo to nonmetallo 3-deoxy-D-manno-octulosonate 8-phosphate synthases
Biochemistry, 46, 2007
2A21
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AQUIFEX AEOLICUS KDO8PS IN COMPLEX WITH PEP, PO4, AND ZN2+
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHATE ION, ZINC ION, ...
Authors:Kona, F., Xu, X., Lu, J., Martin, P., Gatti, D.L.
Deposit date:2005-06-21
Release date:2006-06-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Electronic structure of the metal center in the Cd(2+), Zn(2+), and Cu(2+) substituted forms of KDO8P synthase: implications for catalysis.
Biochemistry, 48, 2009
2A2I
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AQUIFEX AEOLICUS KDO8PS IN COMPLEX WITH PEP, A5P, ZN2+
Descriptor:2-dehydro-3-deoxyphosphooctonate aldolase, ZINC ION, PHOSPHOENOLPYRUVATE, ...
Authors:Kona, F., Xu, X., Lu, J., Martin, P., Gatti, D.L.
Deposit date:2005-06-22
Release date:2006-07-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Electronic structure of the metal center in the Cd(2+), Zn(2+), and Cu(2+) substituted forms of KDO8P synthase: implications for catalysis.
Biochemistry, 48, 2009
1RPI
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CRYSTAL STRUCTURES OF A MULTIDRUG-RESISTANT HIV-1 PROTEASE REVEAL AN EXPANDED ACTIVE SITE CAVITY
Descriptor:protease, ALPHA-D-GLUCOSE
Authors:Logsdon, B.C., Vickrey, J.F., Martin, P., Proteasa, G., Koepke, J.I., Terlecky, S.R., Wawrzak, Z., Winters, M.A., Merigan, T.C., Kovari, L.C.
Deposit date:2003-12-03
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
J.Virol., 78, 2004
1RQ9
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CRYSTAL STRUCTURES OF A MULTIDRUG-RESISTANT HIV-1 PROTEASE REVEAL AN EXPANDED ACTIVE SITE CAVITY
Descriptor:protease, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE
Authors:Logsdon, B.C., Vickrey, J.F., Martin, P., Proteasa, G., Koepke, J.I., Terlecky, S.R., Wawrzak, Z., Winters, M.A., Merigan, T.C., Kovari, L.C.
Deposit date:2003-12-04
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
J.Virol., 78, 2004
1RV7
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CRYSTAL STRUCTURES OF A MULTIDRUG-RESISTANT HIV-1 PROTEASE REVEAL AN EXPANDED ACTIVE SITE CAVITY
Descriptor:protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE
Authors:Logsdon, B.C., Vickrey, J.F., Martin, P., Proteasa, G., Koepke, J.I., Terlecky, S.R., Wawrzak, Z., Winters, M.A., Merigan, T.C., Kovari, L.C.
Deposit date:2003-12-12
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
J.Virol., 78, 2004
1TP3
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PDZ3 DOMAIN OF PSD-95 PROTEIN COMPLEXED WITH KKETPV PEPTIDE LIGAND
Descriptor:Presynaptic density protein 95, KKETPV peptide ligand
Authors:Saro, D., Martin, P., Vickrey, J.F., Griffin, A., Kovari, L.C., Spaller, M.R.
Deposit date:2004-06-15
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structure of the third PDZ domain of PSD-95 protein complexed with KKETPV peptide ligand
To be Published
1TP5
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CRYSTAL STRUCTURE OF PDZ3 DOMAIN OF PSD-95 PROTEIN COMPLEXED WITH A PEPTIDE LIGAND KKETWV
Descriptor:Presynaptic density protein 95, LYS-LYS-GLU-THR-TRP-VAL peptide ligand
Authors:Saro, D., Wawrzak, Z., Martin, P., Vickrey, J., Paredes, A., Kovari, L., Spaller, M.
Deposit date:2004-06-15
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structure of the third PDZ domain of PSD-95 protein complexed with KKETWV peptide ligand
To be Published
1U2W
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CRYSTAL STRUCTURE OF THE STAPHYLOCOCCUS AUREUS PI258 CADC
Descriptor:Cadmium efflux system accessory protein, ZINC ION
Authors:Ye, J., Kandegedara, A., Martin, P., Rosen, B.P.
Deposit date:2004-07-20
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the Staphylococcus aureus pI258 CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor
J.Bacteriol., 187, 2005
410D
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DUPLEX [5'-D(GCGTA+TACGC)]2 WITH INCORPORATED 2'-O-ETHOXYMETHYLENE RIBONUCLEOSIDE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(T38)P*AP*CP*GP*C)-3'), SPERMINE
Authors:Tereshko, V., Portmann, S., Tay, E.C., Martin, P., Natt, F., Altmann, K.H., Egli, M.
Deposit date:1998-06-30
Release date:1998-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues.
Biochemistry, 37, 1998
411D
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DUPLEX [5'-D(GCGTA+TACGC)]2 WITH INCORPORATED 2'-O-METHOXYETHYL RIBONUCLEOSIDE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(T39)P*AP*CP*GP*C)-3')
Authors:Tereshko, V., Portmann, S., Tay, E.C., Martin, P., Natt, F., Altmann, K.H., Egli, M.
Deposit date:1998-06-30
Release date:1998-07-17
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues.
Biochemistry, 37, 1998
412D
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DUPLEX [5'-D(GCGTA+TACGC)]2 WITH INCORPORATED 2'-O-METHYL-[TRI(OXYETHYL)] RIBONUCLEOSIDE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3'), MAGNESIUM ION
Authors:Tereshko, V., Portmann, S., Tay, E.C., Martin, P., Natt, F., Altmann, K.H., Egli, M.
Deposit date:1998-06-30
Release date:1998-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues.
Biochemistry, 37, 1998
1BBR
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THE STRUCTURE OF RESIDUES 7-16 OF THE A ALPHA CHAIN OF HUMAN FIBRINOGEN BOUND TO BOVINE THROMBIN AT 2.3 ANGSTROMS RESOLUTION
Descriptor:EPSILON-THROMBIN, FIBRINOGEN ALPHA/ALPHA-E CHAIN PRECURSOR
Authors:Martin, P., Edwards, B.
Deposit date:1992-04-27
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
J.Biol.Chem., 267, 1992
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