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2VVS
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BTGH84 STRUCTURE IN COMPLEX WITH PUGNAC
Descriptor:O-GLCNACASE BT_4395, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE
Authors:Macauley, M.S., Bubb, A., Martinez-Fleites, C., Davies, G.J., Vocadlo, D.J.
Deposit date:2008-06-11
Release date:2008-09-30
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Elevation of Global O-Glcnac Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-Glcnacase Does not Induce Insulin Resistance
J.Biol.Chem., 283, 2008
2CHN
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BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY- NAG-THIAZOLINE COMPLEX
Descriptor:GLUCOSAMINIDASE, CALCIUM ION, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, ...
Authors:Dennis, R.J., Taylor, E.J., Macauley, M.S., Stubbs, K.A., Turkenburg, J.P., Hart, S.J., Black, G.N., Vocadlo, D.J., Davies, G.J.
Deposit date:2006-03-15
Release date:2006-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and Mechanism of a Bacterial B-Glucosaminidase Having O-Glcnacase Activity
Nat.Struct.Mol.Biol., 13, 2006
2CHO
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BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY
Descriptor:GLUCOSAMINIDASE, CALCIUM ION, ACETATE ION, ...
Authors:Dennis, R.J., Taylor, E.J., Macauley, M.S., Stubbs, K.A., Turkenburg, J.P., Hart, S.J., Black, G.N., Vocadlo, D.J., Davies, G.J.
Deposit date:2006-03-16
Release date:2006-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and Mechanism of a Bacterial B-Glucosaminidase Having O-Glcnacase Activity
Nat.Struct.Mol.Biol., 13, 2006
2VSN
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STRUCTURE AND TOPOLOGICAL ARRANGEMENT OF AN O-GLCNAC TRANSFERASE HOMOLOG: INSIGHT INTO MOLECULAR CONTROL OF INTRACELLULAR GLYCOSYLATION
Descriptor:XCOGT, URIDINE-5'-DIPHOSPHATE
Authors:Martinez-Fleites, C., Macauley, M.S., He, Y., Shen, D., Vocadlo, D., Davies, G.J.
Deposit date:2008-04-28
Release date:2008-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of an O-Glcnac Transferase Homolog Provides Insight Into Intracellular Glycosylation.
Nat.Struct.Mol.Biol., 15, 2008
2W91
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STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FAMILY 85 GLYCOSIDE HYDROLASE, ENDO-D.
Descriptor:ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D, PENTAETHYLENE GLYCOL
Authors:Abbott, D.W., Macauley, M.S., Vocadlo, D.J., Boraston, A.B.
Deposit date:2009-01-21
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Streptococcus Pneumoniae Endohexosaminidase D, Structural and Mechanistic Insight Into Substrate-Assisted Catalysis in Family 85 Glycoside Hydrolases.
J.Biol.Chem., 284, 2009
2W92
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STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FAMILY 85 GLYCOSIDE HYDROLASE, ENDO-D, IN COMPLEX WITH NAG-THIAZOLINE.
Descriptor:ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D, PENTAETHYLENE GLYCOL, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL
Authors:Abbott, D.W., Macauley, M.S., Vocadlo, D.J., Boraston, A.B.
Deposit date:2009-01-21
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Streptococcus Pneumoniae Endohexosaminidase D, Structural and Mechanistic Insight Into Substrate-Assisted Catalysis in Family 85 Glycoside Hydrolases.
J.Biol.Chem., 284, 2009
2XJ7
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BTGH84 IN COMPLEX WITH 6-ACETAMIDO-6-DEOXY-CASTANOSPERMINE
Descriptor:O-GLCNACASE BT_4395, 6-ACETAMIDO-6-DEOXY-CASTANOSPERMINE, CALCIUM ION
Authors:He, Y., Davies, G.J.
Deposit date:2010-07-02
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of O-Glcnacase Using a Potent and Cell-Permeable Inhibitor Does not Induce Insulin Resistance in 3T3-L1 Adipocytes.
Chem.Biol., 17, 2010
4AIS
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A COMPLEX STRUCTURE OF BTGH84
Descriptor:O-GLCNACASE BT_4395, GLYCOLIC ACID, GLYCEROL
Authors:He, Y., Davies, G.J.
Deposit date:2012-02-13
Release date:2012-06-20
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: Intracellular Beta-O-Linked N-Glycolylglucosamine (Glcngc), Udp-Glcngc, and the Biochemical and Structural Rationale for the Substrate Tolerance of Beta-O-Linked Beta-N-Acetylglucosaminidase.
J.Biol.Chem., 287, 2012
4AIU
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A COMPLEX STRUCTURE OF BTGH84
Descriptor:O-GLCNACASE BT_4395, (3AR,5R,6S,7R,7AR)-2,5-BIS(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]OXAZOLE-6,7-DIOL, CALCIUM ION
Authors:He, Y., Davies, G.J.
Deposit date:2012-02-13
Release date:2012-06-20
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: Intracellular Beta-O-Linked N-Glycolylglucosamine (Glcngc), Udp-Glcngc, and the Biochemical and Structural Rationale for the Substrate Tolerance of Beta-O-Linked Beta-N-Acetylglucosaminidase.
J.Biol.Chem., 287, 2012
2J4G
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH N-BUTYL- THIAZOLINE INHIBITOR
Descriptor:HYALURONOGLUCOSAMINIDASE, (3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-PROPYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL, ACETATE ION, ...
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2006-08-31
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Analysis of Pugnac and Nag-Thiazoline as Transition State Analogues for Human O-Glcnacase: Mechanistic and Structural Insights Into Inhibitor Selectivity and Transition State Poise.
J.Am.Chem.Soc., 129, 2007
2VVN
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BTGH84 IN COMPLEX WITH NH-BUTYLTHIAZOLINE
Descriptor:O-GLCNACASE BT_4395, GLYCEROL, AMMONIUM ION, ...
Authors:He, Y., Davies, G.J.
Deposit date:2008-06-10
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Potent Mechanism-Inspired O-Glcnacase Inhibitor that Blocks Phosphorylation of Tau in Vivo.
Nat.Chem.Biol., 4, 2008
2WZH
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BTGH84 D242N IN COMPLEX WITH MEUMB-DERIVED OXAZOLINE
Descriptor:O-GLCNACASE BT_4395, 2-METHYL-4,5-DIHYDRO-(1,2-DIDEOXY-ALPHA-D-GLUCOPYRANOSO)[2,1-D]-1,3-OXAZOLE, GLYCEROL, ...
Authors:He, Y., Davies, G.J.
Deposit date:2009-11-30
Release date:2010-01-26
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Visualizing the Reaction Coordinate of an O-Glcnac Hydrolase
J.Am.Chem.Soc., 132, 2010
2WZI
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BTGH84 D243N IN COMPLEX WITH 5F-OXAZOLINE
Descriptor:O-GLCNACASE BT_4395, GLYCEROL, CALCIUM ION, ...
Authors:He, Y., Davies, G.J.
Deposit date:2009-11-30
Release date:2010-01-26
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Visualizing the Reaction Coordinate of an O-Glcnac Hydrolase
J.Am.Chem.Soc., 132, 2010
2X0H
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BTGH84 MICHAELIS COMPLEX
Descriptor:O-GLCNACASE BT_4395, 3,4-DIFLUOROPHENYL 2-DEOXY-2-[(DIFLUOROACETYL)AMINO]-BETA-D-GLUCOPYRANOSIDE, GLYCEROL, ...
Authors:He, Y., Davies, G.J.
Deposit date:2009-12-08
Release date:2010-01-26
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Visualizing the Reaction Coordinate of an O-Glcnac Hydrolase
J.Am.Chem.Soc., 132, 2010
2J47
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR
Descriptor:GLUCOSAMINIDASE, (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE, GLYCEROL
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2006-08-25
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Inhibition of O-Glcnacase by a Gluco-Configured Nagstatin and a Pugnac-Imidazole Hybrid Inhibitor
Chem. Commun., 42, 2006
2JIW
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH 2- ACETYLAMINO-2-DEOXY-1-EPIVALIENAMINE
Descriptor:O-GLCNACASE BT_4395, N-[(1S,2R,5R,6R)-2-AMINO-5,6-DIHYDROXY-4-(HYDROXYMETHYL)CYCLOHEX-3-EN-1-YL]ACETAMIDE
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2007-07-02
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A 1-Acetamido Derivative of 6-Epi-Valienamine: An Inhibitor of a Diverse Group of Beta-N-Acetylglucosaminidases.
Org.Biomol.Chem., 5, 2007