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2GEW
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ATOMIC RESOLUTION STRUCTURE OF CHOLESTEROL OXIDASE @ PH 9.0 (STREPTOMYCES SP. SA-COO)
Descriptor:Cholesterol oxidase, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Lyubimov, A.Y., Vrielink, A.
Deposit date:2006-03-20
Release date:2006-05-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment.
Nat.Chem.Biol., 2, 2006
3B3R
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CRYSTAL STRUCTURE OF STREPTOMYCES CHOLESTEROL OXIDASE H447Q/E361Q MUTANT BOUND TO GLYCEROL (0.98A)
Descriptor:Cholesterol oxidase, SULFATE ION, FLAVIN-N7 PROTONATED-ADENINE DINUCLEOTIDE, ...
Authors:Lyubimov, A.Y., Heard, K., Tang, H., Sampson, N.S., Vrielink, A.
Deposit date:2007-10-22
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase
Protein Sci., 16, 2007
3B6D
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CRYSTAL STRUCTURE OF STREPTOMYCES CHOLESTEROL OXIDASE H447Q/E361Q MUTANT (1.2A)
Descriptor:Cholesterol oxidase, SULFATE ION, FLAVIN-N7 PROTONATED-ADENINE DINUCLEOTIDE
Authors:Lyubimov, A.Y., Vrielink, A.
Deposit date:2007-10-29
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase
Protein Sci., 16, 2007
3GYI
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CHOLESTEROL OXIDASE FROM STREPTOMYCES SP. N485D MUTANT (1.0A)
Descriptor:Cholesterol oxidase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION
Authors:Lyubimov, A.Y., Vrielink, A.
Deposit date:2009-04-03
Release date:2009-12-01
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1 Å)
Cite:A hydrogen-bonding network is important for oxidation and isomerization in the reaction catalyzed by cholesterol oxidase.
Acta Crystallogr.,Sect.D, 65, 2009
3GYJ
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CHOLESTEROL OXIDASE FROM STREPTOMYCES SP. N485L MUTANT (0.92A)
Descriptor:Cholesterol oxidase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION
Authors:Lyubimov, A.Y., Vrielink, A.
Deposit date:2009-04-03
Release date:2009-12-01
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (0.92 Å)
Cite:A hydrogen-bonding network is important for oxidation and isomerization in the reaction catalyzed by cholesterol oxidase.
Acta Crystallogr.,Sect.D, 65, 2009
4WMG
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STRUCTURE OF HEN EGG-WHITE LYSOZYME FROM A MICROFLUDIC HARVESTING DEVICE USING SYNCHROTRON RADIATION (2.5A)
Descriptor:Lysozyme C
Authors:Lyubimov, A.Y., Murray, T.D., Koehl, A., Uervirojnangkoorn, M., Zeldin, O.B., Cohen, A.E., Soltis, S.M., Baxter, E.M., Brewster, A.S., Sauter, N.K., Brunger, A.T., Berger, J.M.
Deposit date:2014-10-08
Release date:2015-04-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array.
Acta Crystallogr.,Sect.D, 71, 2015
5KJ7
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STRUCTURE OF THE CA2+-BOUND SYNAPTOTAGMIN-1 SNARE COMPLEX (LONG UNIT CELL FORM) - FROM XFEL DIFFRACTION
Descriptor:Vesicle-associated membrane protein 3, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Lyubimov, A.Y., Uervirojnangkoorn, M., Zhou, Q., Zhao, M., Sauter, N.K., Brewster, A.S., Weis, W.I., Brunger, A.T.
Deposit date:2016-06-17
Release date:2016-10-19
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex.
Elife, 5, 2016
5KJ8
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STRUCTURE OF THE CA2+-BOUND SYNAPTOTAGMIN-1 SNARE COMPLEX (LONG UNIT CELL FORM) - FROM SYNCHROTRON DIFFRACTION
Descriptor:Vesicle-associated membrane protein 3, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Lyubimov, A.Y., Uervirojnangkoorn, M., Zhou, Q., Zhao, M., Sauter, N.K., Brewster, A.S., Weis, W.I., Brunger, A.T.
Deposit date:2016-06-17
Release date:2016-10-19
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex.
Elife, 5, 2016
3CNJ
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CHOLESTEROL OXIDASE FROM STREPTOMYCES SP. F359W MUTANT (0.95A)
Descriptor:Cholesterol oxidase, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Lyubimov, A.Y., Brammer, L., Vrielink, A.
Deposit date:2008-03-25
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:The binding and release of oxygen and hydrogen peroxide are directed by a hydrophobic tunnel in cholesterol oxidase
Biochemistry, 47, 2008
4NMN
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AQUIFEX AEOLICUS REPLICATIVE HELICASE (DNAB) COMPLEXED WITH ADP, AT 3.3 RESOLUTION
Descriptor:Replicative DNA helicase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lyubimov, A.Y., Strycharska, M.S., Erzberger, J.P., Berger, J.M.
Deposit date:2013-11-15
Release date:2014-01-29
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Nucleotide and partner-protein control of bacterial replicative helicase structure and function.
Mol.Cell, 52, 2013
5TJ3
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CRYSTAL STRUCTURE OF WILD TYPE ALKALINE PHOSPHATASE PAFA TO 1.7A RESOLUTION
Descriptor:Alkaline phosphatase PafA, ZINC ION
Authors:Lyubimov, A.Y., Sunden, F., Ressl, S., Herschlag, D.
Deposit date:2016-10-03
Release date:2016-11-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase Superfamily.
J.Am.Chem.Soc., 138, 2016
6APK
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TRANS-ACTING TRANSFERASE FROM DISORAZOLE SYNTHASE SOLVED BY SERIAL FEMTOSECOND XFEL CRYSTALLOGRAPHY
Descriptor:DisD protein
Authors:Lyubimov, A.Y., Mathews, I.I., Uervivojnangkoorn, M., Khosla, C., Soltis, S.M., Cohen, A.E.
Deposit date:2017-08-17
Release date:2018-04-04
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.
Biochemistry, 56, 2017
6APM
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HEN EGG-WHITE LYSOZYME (WT), SOLVED WITH SERIAL MILLISECOND CRYSTALLOGRAPHY USING SYNCHROTRON RADIATION
Descriptor:Lysozyme C, SODIUM ION
Authors:Lyubimov, A.Y., Mathews, I.I., Uervivojnangkoorn, M., Soltis, S.M., Cohen, A.E.
Deposit date:2017-08-17
Release date:2018-04-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.
Biochemistry, 56, 2017
2IID
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STRUCTURE OF L-AMINO ACID OXIDASE FROM CALLOSELASMA RHODOSTOMA IN COMPLEX WITH L-PHENYLALANINE
Descriptor:L-amino-acid oxidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Moustafa, I.M., Foster, S., Lyubimov, A.Y., Vrielink, A.
Deposit date:2006-09-27
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of LAAO from Calloselasma rhodostoma with an L-Phenylalanine Substrate: Insights into Structure and Mechanism
J.Mol.Biol., 364, 2006
3KDE
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CRYSTAL STRUCTURE OF THE THAP DOMAIN FROM D. MELANOGASTER P-ELEMENT TRANSPOSASE IN COMPLEX WITH ITS NATURAL DNA BINDING SITE
Descriptor:5'-D(*GP*TP*TP*AP*AP*GP*(BRU)P*GP*GP*A)-3', 5'-D(*(BRU)P*CP*CP*AP*CP*TP*TP*AP*AP*C)-3', Transposable element P transposase, ...
Authors:Sabogal, A., Lyubimov, A.Y., Berger, J.M., Rio, D.C.
Deposit date:2009-10-22
Release date:2009-12-08
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves.
Nat.Struct.Mol.Biol., 17, 2010
4TMA
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CRYSTAL STRUCTURE OF GYRASE BOUND TO ITS INHIBITOR YACG
Descriptor:DNA gyrase subunit A, DNA gyrase subunit B, DNA gyrase inhibitor YacG, ...
Authors:Vos, S.M., Lyubimov, A.Y., Hershey, D.M., Schoeffler, A.J., Berger, J.M.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein.
Genes Dev., 28, 2014
4Z98
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CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME USING SERIAL X-RAY DIFFRACTION DATA COLLECTION
Descriptor:Lysozyme C, ACETATE ION
Authors:Murray, T.D., Lyubimov, A.Y., Ogata, C.M., Uervirojnangkoorn, M., Brunger, A.T., Berger, J.M.
Deposit date:2015-04-10
Release date:2015-10-14
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
5CCG
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STRUCTURE OF THE CA2+-BOUND SYNAPTOTAGMIN-1 SNARE COMPLEX (LONG UNIT CELL FORM)
Descriptor:Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T.
Deposit date:2015-07-02
Release date:2015-08-12
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
5CCH
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STRUCTURE OF THE CA2+-BOUND SYNAPTOTAGMIN-1 SNARE COMPLEX (SHORT UNIT CELL FORM)
Descriptor:Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T.
Deposit date:2015-07-02
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
5CCI
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STRUCTURE OF THE MG2+-BOUND SYNAPTOTAGMIN-1 SNARE COMPLEX (SHORT UNIT CELL FORM)
Descriptor:Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Weis, W.I., Brunger, A.T.
Deposit date:2015-07-02
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
5KAF
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RT XFEL STRUCTURE OF PHOTOSYSTEM II IN THE DARK STATE AT 3.0 A RESOLUTION
Descriptor:Photosystem II protein D1 1, Photosystem II CP47 reaction center protein, Photosystem II CP43 reaction center protein, ...
Authors:Young, I.D., Ibrahim, M., Chatterjee, R., Gul, S., Koroidov, S., Brewster, A.S., Tran, R., Alonso-Mori, R., Fuller, F., Kroll, T., Michels-Clark, T., Laksmono, H., Sierra, R.G., Stan, C.A., Saracini, C., Bean, M.A., Seuffert, I., Sokaras, D., Weng, T.-C., Hunter, M.S., Aquila, A., Koglin, J.E., Robinson, J., Liang, M., Boutet, S., Lyubimov, A.Y., Uervirojnangkoorn, M., Moriarty, N.W., Liebschner, D., Afonine, P.V., Waterman, D.G., Evans, G., Dobbek, H., Weis, W.I., Brunger, A.T., Zwart, P.H., Adams, P.D., Zouni, A., Messinger, J., Bergmann, U., Sauter, N.K., Kern, J., Yachandra, V.K., Yano, J.
Deposit date:2016-06-01
Release date:2016-11-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.00001 Å)
Cite:Structure of photosystem II and substrate binding at room temperature.
Nature, 540, 2016
5KAI
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NH3-BOUND RT XFEL STRUCTURE OF PHOTOSYSTEM II 500 MS AFTER THE 2ND ILLUMINATION (2F) AT 2.8 A RESOLUTION
Descriptor:Photosystem II protein D1 1, Photosystem II CP47 reaction center protein, Photosystem II CP43 reaction center protein, ...
Authors:Young, I.D., Ibrahim, M., Chatterjee, R., Gul, S., Koroidov, S., Brewster, A.S., Tran, R., Alonso-Mori, R., Fuller, F., Kroll, T., Michels-Clark, T., Laksmono, H., Sierra, R.G., Stan, C.A., Saracini, C., Bean, M.A., Seuffert, I., Sokaras, D., Weng, T.-C., Hunter, M.S., Aquila, A., Koglin, J.E., Robinson, J., Liang, M., Boutet, S., Lyubimov, A.Y., Uervirojnangkoorn, M., Moriarty, N.W., Liebschner, D., Afonine, P.V., Waterman, D.G., Evans, G., Dobbek, H., Weis, W.I., Brunger, A.T., Zwart, P.H., Adams, P.D., Zouni, A., Messinger, J., Bergmann, U., Sauter, N.K., Kern, J., Yachandra, V.K., Yano, J.
Deposit date:2016-06-01
Release date:2016-11-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.800009 Å)
Cite:Structure of photosystem II and substrate binding at room temperature.
Nature, 540, 2016
5TIS
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ROOM TEMPERATURE XFEL STRUCTURE OF THE NATIVE, DOUBLY-ILLUMINATED PHOTOSYSTEM II COMPLEX
Descriptor:Photosystem II protein D1 1, Photosystem II CP47 reaction center protein, Photosystem II CP43 reaction center protein, ...
Authors:Young, I.D., Ibrahim, M., Chatterjee, R., Gul, S., Fuller, F., Koroidov, S., Brewster, A.S., Tran, R., Alonso-Mori, R., Kroll, T., Michels-Clark, T., Laksmono, H., Sierra, R.G., Stan, C.A., Hussein, R., Zhang, M., Douthit, L., Kubin, M., de Lichtenberg, C., Pham, L.V., Nilsson, H., Cheah, M.H., Shevela, D., Saracini, C., Bean, M.A., Seuffert, I., Sokaras, D., Weng, T.-C., Pastor, E., Weninger, C., Fransson, T., Lassalle, L., Braeuer, P., Aller, P., Docker, P.T., Andi, B., Orville, A.M., Glownia, J.M., Nelson, S., Sikorski, M., Zhu, D., Hunter, M.S., Aquila, A., Koglin, J.E., Robinson, J., Liang, M., Boutet, S., Lyubimov, A.Y., Uervirojnangkoorn, M., Moriarty, N.W., Liebschner, D., Afonine, P.V., Watermann, D.G., Evans, G., Wernet, P., Dobbek, H., Weis, W.I., Brunger, A.T., Zwart, P.H., Adams, P.D., Zouni, A., Messinger, J., Bergmann, U., Sauter, N.K., Kern, J., Yachandra, V.K., Yano, J.
Deposit date:2016-10-03
Release date:2016-11-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.250004 Å)
Cite:Structure of photosystem II and substrate binding at room temperature.
Nature, 540, 2016
6APG
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TRANS-ACTING TRANSFERASE FROM DISORAZOLE SYNTHASE WITH MALONATE
Descriptor:DisD protein, MALONATE ION, GLYCEROL, ...
Authors:Mathews, I.I., Lyubimov, A.Y., Soltis, S.M., Khosla, C., Robbins, T., Cohen, A.E.
Deposit date:2017-08-17
Release date:2018-04-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.
Biochemistry, 56, 2017
5TOO
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CRYSTAL STRUCTURE OF ALKALINE PHOSPHATASE PAFA T79S, N100A, K162A, R164A MUTANT
Descriptor:Alkaline phosphatase PafA, ZINC ION, CHLORIDE ION
Authors:Lyubimov, A.Y., Sunden, F., AlSadhan, I., Herschlag, D.
Deposit date:2016-10-18
Release date:2017-11-01
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.031 Å)
Cite:Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution.
J. Biol. Chem., 292, 2017
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