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1PGE
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PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH P-(2'-IODO-5'-THENOYL)HYDROTROPIC ACID (IODOSUPROFEN)
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Loll, P.J., Picot, D., Garavito, R.M.
Deposit date:1995-12-02
Release date:1997-01-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
Biochemistry, 35, 1996
1PGF
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PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Loll, P.J., Picot, D., Garavito, R.M.
Deposit date:1995-12-02
Release date:1997-01-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
Biochemistry, 35, 1996
1PGG
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PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), TRANS MODEL
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Loll, P.J., Picot, D., Garavito, R.M.
Deposit date:1995-12-02
Release date:1997-01-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
Biochemistry, 35, 1996
1PTH
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THE STRUCTURAL BASIS OF ASPIRIN ACTIVITY INFERRED FROM THE CRYSTAL STRUCTURE OF INACTIVATED PROSTAGLANDIN H2 SYNTHASE
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Loll, P.J., Picot, D., Garavito, R.M.
Deposit date:1995-04-11
Release date:1996-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase.
Nat.Struct.Biol., 2, 1995
1SNM
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ACTIVE SITE MUTANT GLU-43 (RIGHT ARROW) ASP IN STAPHYLOCOCCAL NUCLEASE DISPLAYS NONLOCAL STRUCTURAL CHANGES
Descriptor:THERMONUCLEASE PRECURSOR, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Loll, P.J., Lattman, E.E.
Deposit date:1990-02-15
Release date:1991-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Active site mutant Glu-43 --> Asp in staphylococcal nuclease displays nonlocal structural changes.
Biochemistry, 29, 1990
4PIG
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CRYSTAL STRUCTURE OF THE UBIQUITIN K11S MUTANT
Descriptor:Ubiquitin, CALCIUM ION, CHLORIDE ION, ...
Authors:Loll, P.J., Xu, P.J., Schmidt, J., Melideo, S.L.
Deposit date:2014-05-08
Release date:2014-10-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Enhancing ubiquitin crystallization through surface-entropy reduction.
Acta Crystallogr.,Sect.F, 70, 2014
4PIH
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X-RAY CRYSTAL STRUCTURE OF THE K33S MUTANT OF UBIQUITIN
Descriptor:Ubiquitin, CALCIUM ION, CHLORIDE ION
Authors:Loll, P.J., Xu, P.J., Schmidt, J., Melideo, S.L.
Deposit date:2014-05-08
Release date:2014-10-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enhancing ubiquitin crystallization through surface-entropy reduction.
Acta Crystallogr.,Sect.F, 70, 2014
4PIJ
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X-RAY CRYSTAL STRUCTURE OF THE K11S/K63S DOUBLE MUTANT OF UBIQUITIN
Descriptor:Ubiquitin, GLYCEROL, SULFATE ION
Authors:Loll, P.J., Xu, P.J., Schmidt, J., Melideo, S.L.
Deposit date:2014-05-08
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enhancing ubiquitin crystallization through surface-entropy reduction.
Acta Crystallogr.,Sect.F, 70, 2014
1AA5
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VANCOMYCIN
Descriptor:VANCOMYCIN, BETA-D-GLUCOSE, (1R,3S,4S,5S)-3-amino-2,3,6-trideoxy-3-methyl-alpha-L-arabino-hexopyranose, ...
Authors:Loll, P.J., Bevivino, A.E., Korty, B.D., Axelsen, P.H.
Deposit date:1997-01-23
Release date:1997-08-20
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (0.89 Å)
Cite:Simultaneous Recognition of a Carboxylate-Containing Ligand and an Intramolecular Surrogate Ligand in the Crystal Structure of an Asymmetric Vancomycin Dimer.
J.Am.Chem.Soc., 119, 1997
1C0Q
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COMPLEX OF VANCOMYCIN WITH 2-ACETOXY-D-PROPANOIC ACID
Descriptor:VANCOMYCIN, BETA-D-GLUCOSE, (1R,3S,4S,5S)-3-amino-2,3,6-trideoxy-3-methyl-alpha-L-arabino-hexopyranose, ...
Authors:Loll, P.J., Kaplan, J., Selinsky, B., Axelsen, P.H.
Deposit date:1999-07-20
Release date:1999-07-30
Last modified:2013-04-10
Method:X-RAY DIFFRACTION (1 Å)
Cite:Vancomycin binding to low-affinity ligands: delineating a minimum set of interactions necessary for high-affinity binding.
J.Med.Chem., 42, 1999
1C0R
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COMPLEX OF VANCOMYCIN WITH D-LACTIC ACID
Descriptor:VANCOMYCIN, BETA-D-GLUCOSE, (1R,3S,4S,5S)-3-amino-2,3,6-trideoxy-3-methyl-alpha-L-arabino-hexopyranose, ...
Authors:Loll, P.J., Kaplan, J., Selinsky, B., Axelsen, P.H.
Deposit date:1999-07-20
Release date:1999-07-30
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1 Å)
Cite:Vancomycin Binding to Low-Affinity Ligands: Delineating a Minimum Set of Interactions Necessary for High-Affinity Binding.
J.Med.Chem., 42, 1999
1EBV
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OVINE PGHS-1 COMPLEXED WITH SALICYL HYDROXAMIC ACID
Descriptor:PROSTAGLANDIN H2 SYNTHASE, N-ACETYL-D-GLUCOSAMINE, ACETIC ACID SALICYLOYL-AMINO-ESTER, ...
Authors:Loll, P.J., Sharkey, C.T., O'Connor, S.J., Fitzgerald, D.J.
Deposit date:2000-01-24
Release date:2000-02-24
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions.
Mol.Pharmacol., 60, 2001
1QD8
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COMPLEX OF VANCOMYCIN WITH N-ACETYL GLYCINE
Descriptor:VANCOMYCIN, BETA-D-GLUCOSE, (1R,3S,4S,5S)-3-amino-2,3,6-trideoxy-3-methyl-alpha-L-arabino-hexopyranose, ...
Authors:Loll, P.J., Kaplan, J., Selinsky, B., Axelsen, P.H.
Deposit date:1999-07-15
Release date:1999-08-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1 Å)
Cite:Vancomycin Binding to Low-Affinity Ligands: Delineating a Minimum Set of Interactions Necessary for High-Affinity Binding.
J.Med.Chem., 42, 1999
1SNC
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THE CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF STAPHYLOCOCCAL NUCLEASE, CA2+, AND THE INHIBITOR PD*TP, REFINED AT 1.65 ANGSTROMS
Descriptor:THERMONUCLEASE PRECURSOR, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Loll, P.J., Lattman, E.E.
Deposit date:1989-07-21
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of the ternary complex of staphylococcal nuclease, Ca2+, and the inhibitor pdTp, refined at 1.65 A.
Proteins, 5, 1989
1STG
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TWO DISTINCTLY DIFFERENT METAL BINDING MODES ARE SEEN IN X-RAY CRYSTAL STRUCTURES OF STAPHYLOCOCCAL NUCLEASE-COBALT(II)-NUCLEOTIDE COMPLEXES
Descriptor:STAPHYLOCOCCAL NUCLEASE, COBALT (II) ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Loll, P.J., Quirk, S., Lattman, E.E.
Deposit date:1994-10-27
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:X-ray crystal structures of staphylococcal nuclease complexed with the competitive inhibitor cobalt(II) and nucleotide.
Biochemistry, 34, 1995
1STH
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TWO DISTINCTLY DIFFERENT METAL BINDING MODES ARE SEEN IN X-RAY CRYSTAL STRUCTURES OF STAPHYLOCOCCAL NUCLEASE-COBALT(II)-NUCLEOTIDE COMPLEXES
Descriptor:STAPHYLOCOCCAL NUCLEASE, COBALT (II) ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Loll, P.J., Quirk, S., Lattman, E.E.
Deposit date:1994-10-27
Release date:1995-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray crystal structures of staphylococcal nuclease complexed with the competitive inhibitor cobalt(II) and nucleotide.
Biochemistry, 34, 1995
3C0C
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X-RAY CRYSTAL STRUCTURE OF THE RAT ENDOPHILIN A2 SH3 DOMAIN
Descriptor:Endophilin-A2
Authors:Loll, P.J., Swain, E.
Deposit date:2008-01-19
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the SH3 domain of rat endophilin A2
To be Published
4M6E
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THE HIGH RESOLUTION STRUCTURE OF TYROCIDINE A REVEALS AN AMPHIPATHIC DIMER
Descriptor:tyrocidine A, (4S)-2-METHYL-2,4-PENTANEDIOL, METHANOL
Authors:Loll, P.J., Economou, N.J., Nahoum, V.
Deposit date:2013-08-09
Release date:2014-03-19
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:The high resolution structure of tyrocidine A reveals an amphipathic dimer.
Biochim.Biophys.Acta, 1838, 2014
1EQG
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THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Loll, P.J., Selinsky, B.S., Gupta, K., Sharkey, C.T.
Deposit date:2000-04-04
Release date:2001-04-11
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Biochemistry, 40, 2001
1EQH
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THE 2.7 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH FLURBIPROFEN
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Loll, P.J., Selinsky, B.S., Gupta, K., Sharkey, C.T.
Deposit date:2000-04-04
Release date:2001-04-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Biochemistry, 40, 2001
2GYD
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COMPLEX OF EQUINE APOFERRITIN WITH THE H-DIAZIFLURANE PHOTOLABELING REAGENT
Descriptor:ferritin L subunit, CADMIUM ION, 2-(1,1-DIFLUOROETHOXY)-1,1,1-TRIFLUOROETHANE
Authors:Loll, P.J., Rossi, M.J., Eckenhoff, R.
Deposit date:2006-05-09
Release date:2006-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions.
Acs Chem.Biol., 1, 2006
1CQE
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PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN
Descriptor:PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1), N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Picot, D., Loll, P.J., Mulichak, A.M., Garavito, R.M.
Deposit date:1999-06-15
Release date:1999-06-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
Nature, 367, 1994
5DEN
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THE FIRST STRUCTURE OF A FULL-LENGTH MAMMALIAN PHENYLALANINE HYDROXYLASE REVEALS THE ARCHITECTURE OF AN AUTO-INHIBITED TETRAMER
Descriptor:Phenylalanine-4-hydroxylase, FE (III) ION
Authors:Arturo, E.C., Loll, P.J., Jaffe, E.K.
Deposit date:2015-08-25
Release date:2016-02-17
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.
Proc.Natl.Acad.Sci.USA, 113, 2016
1GHG
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CRYSTAL STRUCTURE OF VANCOMYCIN AGLYCON
Descriptor:VANCOMYCIN AGLYCON, ACETIC ACID, DIMETHYL SULFOXIDE
Authors:Kaplan, J., Korty, B.D., Axelsen, P.H., Loll, P.J.
Deposit date:2000-12-13
Release date:2001-02-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:The Role of Sugar Residues in Molecular Recognition by Vancomycin
J.Med.Chem., 44, 2001
1HT5
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THE 2.75 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH METHYL ESTER FLURBIPROFEN
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, B-OCTYLGLUCOSIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Selinsky, B.S., Gupta, K., Sharkey, C.T., Loll, P.J.
Deposit date:2000-12-28
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Biochemistry, 40, 2001
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