3U7U
| Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuregulin 1, Receptor tyrosine-protein kinase erbB-4 | Authors: | Liu, P, Cleveland IV, T.E, Bouyain, S, Longo, P.A, Leahy, D.J. | Deposit date: | 2011-10-14 | Release date: | 2012-08-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | A single ligand is sufficient to activate EGFR dimers. Proc.Natl.Acad.Sci.USA, 109, 2012
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5TDH
| The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, P, Jia, M.-Z, Zhou, X.E, de Waal, P.W, Dickson, B.M, Liu, B, Hou, L, Yin, Y.-T, Kang, Y.-Y, Shi, Y, Melcher, K, Xu, H.E, Jiang, Y. | Deposit date: | 2016-09-19 | Release date: | 2016-11-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer Acta Pharmacol.Sin., 37, 2016
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1TQH
| Covalent Reaction intermediate Revealed in Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est30 | Descriptor: | Carboxylesterase precursor, PROPYL ACETATE, SULFATE ION | Authors: | Liu, P, Wang, Y.F, Ewis, H.E, Abdelal, A.T, Lu, C.D, Harrison, R.W, Weber, I.T. | Deposit date: | 2004-06-17 | Release date: | 2004-09-28 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30. J.Mol.Biol., 342, 2004
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2RCV
| Crystal structure of the Bacillus subtilis superoxide dismutase | Descriptor: | MANGANESE (II) ION, Superoxide dismutase [Mn] | Authors: | Liu, P, Ewis, H.E, Huang, Y.J, Lu, C.D, Tai, P.C, Weber, I.T. | Deposit date: | 2007-09-20 | Release date: | 2008-02-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of Bacillus subtilis superoxide dismutase. Acta Crystallogr.,Sect.F, 63, 2007
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2R9B
| Structural Analysis of Plasmepsin 2 from Plasmodium falciparum complexed with a peptide-based inhibitor | Descriptor: | Plasmepsin-2, peptide-based inhibitor | Authors: | Liu, P, Marzahn, M.R, Robbins, A.H, McKenna, R, Dunn, B.M. | Deposit date: | 2007-09-12 | Release date: | 2007-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis. Biochemistry, 48, 2009
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3U2P
| Crystal structure of N-terminal three extracellular domains of ErbB4/Her4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4 | Authors: | Liu, P, Bouyain, S, Elgenbrot, C, Leahy, D.J. | Deposit date: | 2011-10-04 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether. Protein Sci., 21, 2012
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2OGT
| Crystal Structure of the Geobacillus Stearothermophilus Carboxylesterase EST55 at pH 6.8 | Descriptor: | GLYCEROL, IODIDE ION, Thermostable carboxylesterase Est50 | Authors: | Liu, P, Ewis, H.E, Tai, P.C, Lu, C.D, Weber, I.T. | Deposit date: | 2007-01-08 | Release date: | 2007-02-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11. J.Mol.Biol., 367, 2007
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2OGS
| Crystal Structure of the GEOBACILLUS STEAROTHERMOPHILUS Carboxylesterase EST55 at pH 6.2 | Descriptor: | IODIDE ION, Thermostable carboxylesterase Est50 | Authors: | Liu, P, Ewis, H.E, Tai, P.C, Lu, C.D, Weber, I.T. | Deposit date: | 2007-01-08 | Release date: | 2007-02-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11. J.Mol.Biol., 367, 2007
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4HQ1
| Crystal structure of an LRR protein with two solenoids | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Probable receptor protein kinase TMK1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Chai, J, Liu, P, Hu, Z, Zhou, B, Liu, S. | Deposit date: | 2012-10-25 | Release date: | 2013-05-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of an LRR protein with two solenoids Cell Res., 23, 2013
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7YJM
| Cryo-EM structure of the monomeric atSPT-ORM1 complex | Descriptor: | Long chain base biosynthesis protein 2a, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, ORMDL family protein, ... | Authors: | Xie, T, Liu, P, Gong, X. | Deposit date: | 2022-07-20 | Release date: | 2023-04-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Sci Adv, 9, 2023
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7YJO
| Cryo-EM structure of the monomeric atSPT-ORM1 (LCB2a-deltaN5) complex | Descriptor: | Long chain base biosynthesis protein 2a, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, ORMDL family protein, ... | Authors: | Xie, T, Liu, P, Gong, X. | Deposit date: | 2022-07-20 | Release date: | 2023-04-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Sci Adv, 9, 2023
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7YJN
| Cryo-EM structure of the monomeric atSPT-ORM1 (ORM1-N17A) complex | Descriptor: | Long chain base biosynthesis protein 1, Long chain base biosynthesis protein 2a, ORMDL family protein, ... | Authors: | Xie, T, Liu, P, Gong, X. | Deposit date: | 2022-07-20 | Release date: | 2023-04-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Sci Adv, 9, 2023
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7YJK
| Cryo-EM structure of the dimeric atSPT-ORM1 complex | Descriptor: | Long chain base biosynthesis protein 1, Long chain base biosynthesis protein 2a, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, ... | Authors: | Xie, T, Liu, P, Gong, X. | Deposit date: | 2022-07-20 | Release date: | 2023-04-05 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Sci Adv, 9, 2023
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8OXG
| Crystal structure of human methionine aminopeptidase-2 complexed with (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl N-(trans-4-aminocyclohexyl)carbamate | Descriptor: | MANGANESE (II) ION, Methionine aminopeptidase 2, [(1~{R},2~{S},3~{S},4~{R})-2-methoxy-4-methyl-3-[(2~{R},3~{S})-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-4-oxidanyl-cyclohexyl] ~{N}-(4-azanylcyclohexyl)carbamate | Authors: | Moss, S, Cornelius, P. | Deposit date: | 2023-05-02 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.731 Å) | Cite: | Pharmacological Characterization of SDX-7320/Evexomostat: a Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-Tumor and Anti-Metastatic Activity. Mol.Cancer Ther., 2024
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8W6R
| murine SMPDL3A bound to sulfate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | Authors: | Zhang, C, Liu, P, Fan, S. | Deposit date: | 2023-08-29 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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8W6P
| Crystal structure of dimeric murine SMPDL3A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | Authors: | Zhang, C, Liu, P, Fan, S, Hou, Y. | Deposit date: | 2023-08-29 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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1REO
| L-amino acid oxidase from Agkistrodon halys pallas | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AHPLAAO, CITRIC ACID, ... | Authors: | Zhang, H, Teng, M, Niu, L, Wang, Y, Wang, Y, Liu, Q, Huang, Q, Hao, Q, Dong, Y, Liu, P. | Deposit date: | 2003-11-07 | Release date: | 2004-05-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom. Acta Crystallogr.,Sect.D, 60, 2004
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1ZZB
| Crystal Structure of CoII HppE in Complex with Substrate | Descriptor: | (S)-2-HYDROXYPROPYLPHOSPHONIC ACID, COBALT (II) ION, Hydroxypropylphosphonic Acid Epoxidase | Authors: | Higgins, L.J, Yan, F, Liu, P, Liu, H.W, Drennan, C.L. | Deposit date: | 2005-06-13 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature, 437, 2005
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1ZZ8
| Crystal Structure of FeII HppE in Complex with Substrate Form 2 | Descriptor: | (S)-2-HYDROXYPROPYLPHOSPHONIC ACID, FE (II) ION, Hydroxypropylphosphonic Acid Epoxidase | Authors: | Higgins, L.J, Yan, F, Liu, P, Liu, H.W, Drennan, C.L. | Deposit date: | 2005-06-13 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature, 437, 2005
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1ZZC
| Crystal Structure of CoII HppE in Complex with Tris Buffer | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COBALT (II) ION, hydroxypropylphosphonic acid epoxidase | Authors: | Higgins, L.J, Yan, F, Liu, P, Liu, H.W, Drennan, C.L. | Deposit date: | 2005-06-13 | Release date: | 2005-07-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature, 437, 2005
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1ZZ6
| Crystal Structure of Apo-HppE | Descriptor: | Hydroxypropylphosphonic Acid Epoxidase | Authors: | Higgins, L.J, Yan, F, Liu, P, Liu, H.W, Drennan, C.L. | Deposit date: | 2005-06-13 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature, 437, 2005
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1ZZ7
| Crystal Structure of FeII HppE in Complex with Substrate form 1 | Descriptor: | (S)-2-HYDROXYPROPYLPHOSPHONIC ACID, FE (II) ION, Hydroxyprophylphosphonic Acid Epoxidase | Authors: | Higgins, L.J, Yan, F, Liu, P, Liu, H.W, Drennan, C.L. | Deposit date: | 2005-06-13 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature, 437, 2005
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1ZZ9
| Crystal Structure of FeII HppE | Descriptor: | FE (II) ION, Hydroxypropylphosphonic Acid Epoxidase, SULFATE ION | Authors: | Higgins, L.J, Yan, F, Liu, P, Liu, H.W, Drennan, C.L. | Deposit date: | 2005-06-13 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature, 437, 2005
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5DO2
| Complex structure of MERS-RBD bound with 4C2 antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4C2 heavy chain, 4C2 light chain, ... | Authors: | Li, Y, Wan, Y, Liu, P, Zhao, J, Lu, G, Qi, J, Wang, Q, Lu, X, Wu, Y, Liu, W, Yuen, K.Y, Perlman, S, Gao, G.F, Yan, J. | Deposit date: | 2015-09-10 | Release date: | 2015-10-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.409 Å) | Cite: | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein. Cell Res., 25, 2015
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5V54
| Crystal structure of 5-HT1B receptor in complex with methiothepin | Descriptor: | 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine, 5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B | Authors: | Yin, W.C, Zhou, X.E, Yang, D, de Waal, P, Wang, M.T, Dai, A, Cai, X, Huang, C.Y, Liu, P, Yin, Y, Liu, B, Caffrey, M, Melcher, K, Xu, Y, Wang, M.W, Xu, H.E, Jiang, Y. | Deposit date: | 2017-03-13 | Release date: | 2018-02-07 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist Cell Discov, 2018
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