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6C3L
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CRYSTAL STRUCTURE OF BCL6 BTB DOMAIN WITH COMPOUND 15F
Descriptor:B-cell lymphoma 6 protein, N-[2-(1H-indol-3-yl)ethyl]-N'-{3-[(4-methylpiperazin-1-yl)methyl]-1-[2-(morpholin-4-yl)-2-oxoethyl]-1H-indol-6-yl}thiourea
Authors:Linhares, B., Cheng, H., Cierpicki, T., Xue, F.
Deposit date:2018-01-10
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.460922 Å)
Cite:Crystal structure of BCL6 BTB domain with compound 15f
To Be Published
6C3N
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CRYSTAL STRUCTURE OF BCL6 BTB DOMAIN IN COMPLEX WITH COMPOUND 7CC5
Descriptor:B-cell lymphoma 6 protein, N-(2-phenylethyl)-N'-pyridin-3-ylthiourea
Authors:Linhares, B., Cheng, H., Xue, F., Cierpicki, T.
Deposit date:2018-01-10
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.531706 Å)
Cite:Crystal structure of BCL6 BTB domain in complex with compound 7CC5
To Be Published
6BXH
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MENIN IN COMPLEX WITH MI-853
Descriptor:Menin, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Borkin, D., Klossowski, S., Pollock, J., Linhares, B., Cierpicki, T., Grembecka, J.
Deposit date:2017-12-18
Release date:2018-11-28
Method:X-RAY DIFFRACTION (2.445 Å)
Cite:Menin in complex with MI-853
To Be Published
6BXY
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MENIN IN COMPLEX WITH MI-1481
Descriptor:Menin, 4-methyl-1-{[(2S)-5-oxomorpholin-2-yl]methyl}-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ...
Authors:Borkin, D., Klossowski, S., Pollock, J., Linhares, B., Cierpicki, T., Grembecka, J.
Deposit date:2017-12-19
Release date:2018-11-28
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
J.Med.Chem., 61, 2018
6BY8
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MENIN IN COMPLEX WITH MI-1482
Descriptor:Menin, 4-methyl-1-{[(2R)-5-oxomorpholin-2-yl]methyl}-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ...
Authors:Borkin, T., Klossowski, S., Pollock, J., Linhares, B., Cierpicki, T., Grembecka, J.
Deposit date:2017-12-20
Release date:2018-11-28
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
J.Med.Chem., 61, 2018