6C3N
Crystal structure of BCL6 BTB domain in complex with compound 7CC5
Summary for 6C3N
| Entry DOI | 10.2210/pdb6c3n/pdb |
| Descriptor | B-cell lymphoma 6 protein, N-(2-phenylethyl)-N'-pyridin-3-ylthiourea (3 entities in total) |
| Functional Keywords | inhibitor, protein-protein interaction, transcription-inhibitor complex, transcription/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 30347.32 |
| Authors | Linhares, B.,Cheng, H.,Xue, F.,Cierpicki, T. (deposition date: 2018-01-10, release date: 2019-01-16, Last modification date: 2023-10-04) |
| Primary citation | Cheng, H.,Linhares, B.M.,Yu, W.,Cardenas, M.G.,Ai, Y.,Jiang, W.,Winkler, A.,Cohen, S.,Melnick, A.,MacKerell Jr., A.,Cierpicki, T.,Xue, F. Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design. J.Med.Chem., 61:7573-7588, 2018 Cited by PubMed: 29969259DOI: 10.1021/acs.jmedchem.8b00040 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.53170577659 Å) |
Structure validation
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