Author results

1EYF
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REFINED STRUCTURE OF THE DNA METHYL PHOSPHOTRIESTER REPAIR DOMAIN OF E. COLI ADA
Descriptor:ADA REGULATORY PROTEIN, ZINC ION
Authors:Lin, Y., Dotsch, V., Wintner, T., Peariso, K., Myers, L.C., Penner-Hahn, J.E., Verdine, G.L., Wagner, G.
Deposit date:2000-05-06
Release date:2003-09-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for the functional switch of the E. coli Ada protein
Biochemistry, 40, 2001
3CGP
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X-RAY STRUCTURE OF A PSEUDOURIDINE-CONTAINING YEAST SPLICEOSOMAL U2 SNRNA-INTRON BRANCH SITE DUPLEX BOUND TO IODIDE IONS
Descriptor:RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3'), SULFATE ION, ...
Authors:Lin, Y., Kielkopf, C.L.
Deposit date:2008-03-06
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGQ
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X-RAY STRUCTURE OF A PSEUDOURIDINE-CONTAINING YEAST SPLICEOSOMAL U2 SNRNA-INTRON BRANCH SITE DUPLEX
Descriptor:RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3'), SULFATE ION
Authors:Lin, Y., Kielkopf, C.L.
Deposit date:2008-03-06
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGR
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X-RAY STRUCTURE CONTAINING THE PSEUDOURIDYLATED U2 SNRNA AND INTRON BRANCH SITE CONSENSUS SEQUENCES
Descriptor:RNA (5'-R(*GP*CP*GP*CP*GP*GP*(PSU)P*AP*GP*UP*GP*C)-3'), RNA (5'-R(*CP*GP*CP*AP*CP*UP*AP*AP*CP*CP*GP*CP*G)-3'), SULFATE ION
Authors:Lin, Y., Kielkopf, C.L.
Deposit date:2008-03-06
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGS
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X-RAY STRUCTURE CONTAINING THE PSEUDOURIDYLATED U2 SNRNA AND MAMMALIAN INTRON BRANCH SITE CONSENSUS SEQUENCES
Descriptor:RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*GP*AP*CP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Lin, Y., Kielkopf, C.L.
Deposit date:2008-03-06
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
4GYR
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GRANULIBACTER BETHESDENSIS ALLOPHANATE HYDROLASE APO
Descriptor:Allophanate hydrolase
Authors:Lin, Y., St Maurice, M.
Deposit date:2012-09-05
Release date:2013-01-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of Allophanate Hydrolase from Granulibacter bethesdensis Provides Insights into Substrate Specificity in the Amidase Signature Family.
Biochemistry, 52, 2013
4GYS
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GRANULIBACTER BETHESDENSIS ALLOPHANATE HYDROLASE CO-CRYSTALLIZED WITH MALONATE
Descriptor:Allophanate hydrolase, MALONATE ION
Authors:Lin, Y., St Maurice, M.
Deposit date:2012-09-05
Release date:2013-01-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:The Structure of Allophanate Hydrolase from Granulibacter bethesdensis Provides Insights into Substrate Specificity in the Amidase Signature Family.
Biochemistry, 52, 2013
5GCN
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CATALYTIC DOMAIN OF TETRAHYMENA GCN5 HISTONE ACETYLTRANSFERASE IN COMPLEX WITH COENZYME A
Descriptor:HISTONE ACETYLTRANSFERASE GCN5, COENZYME A
Authors:Lin, Y., Fletcher, C.M., Zhou, J., Allis, C.D., Wagner, G.
Deposit date:1999-03-24
Release date:1999-07-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A
Nature, 400, 1999
3U0J
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CRYSTAL STRUCTURE OF ADP-RIBOSYLTRANSFERASE HOPU1 OF PSEUDOMONAS SYRINGAE PV. TOMATO DC3000
Descriptor:Type III effector HopU1
Authors:Lin, Y., Yang, H., Wang, P., Xu, Y.
Deposit date:2011-09-28
Release date:2011-11-02
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity
J.Biol.Chem., 286, 2011
1I7K
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CRYSTAL STRUCTURE OF HUMAN MITOTIC-SPECIFIC UBIQUITIN-CONJUGATING ENZYME, UBCH10
Descriptor:UBIQUITIN-CONJUGATING ENZYME E2 H10
Authors:Basavappa, R., Lin, Y.
Deposit date:2001-03-09
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10.
J.Biol.Chem., 277, 2002
5DV5
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THE FATTY ACID-RESPONSIVE FADR REPRESSOR OF VIBRIO ALGINOLYTICUS COMPLEX WITH PALMITOYL-COA
Descriptor:GntR family transcriptional regulator, Palmitoyl-CoA
Authors:Lin, Y., Li, D.F., Feng, Y.J.
Deposit date:2015-09-21
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Snapshort of Vibrio FadR-ligand complex structure reveals a new mechanism for bacterial fatty acid sensing
To Be Published
5XGF
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THE FATTY ACID-RESPONSIVE FADR REPRESSOR OF VIBRIO ALGINOLYTICUS
Descriptor:Fatty acid metabolism regulator protein, NICKEL (II) ION
Authors:Lin, Y., Li, D.F., Feng, Y.J.
Deposit date:2017-04-13
Release date:2017-05-31
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Snapshort of Vibrio FadR-ligand complex structure reveals a new mechanism for bacterial fatty acid sensing
To Be Published
4RYL
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HUMAN PROTEIN ARGININE METHYLTRANSFERASE 3 IN COMPLEX WITH 1-ISOQUINOLIN-6-YL-3-[2-OXO-2-(PYRROLIDIN-1-YL)ETHYL]UREA
Descriptor:PRMT3 protein, 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, UNKNOWN ATOM OR ION
Authors:Dong, A., Dobrovetsky, E., Kaniskan, H.U., Szewczyk, M., Yu, Z., Eram, M.S., Yang, X., Schmidt, K., Luo, X., Dai, M., He, F., Zang, I., Lin, Y., Kennedy, S., Li, F., Tempel, W., Smil, D., Min, S.J., Landon, M., Lin-Jones, J., Huang, X.P., Roth, B.L., Schapira, M., Atadja, P., Barsyte-Lovejoy, D., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Brown, P.J., Zhao, K., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)
Deposit date:2014-12-15
Release date:2015-02-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).
Angew.Chem.Int.Ed.Engl., 54, 2015
5U6I
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DISCOVERY OF MLI-2, AN ORALLY AVAILABLE AND SELECTIVE LRRK2 INHIBITOR THAT REDUCES BRAIN KINASE ACTIVITY
Descriptor:Mitogen-activated protein kinase 1, 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, SULFATE ION
Authors:Scott, J.D., DeMong, D.E., Fell, M.J., Mirescu, C., Basu, K., Greshock, T.J., Morrow, J.A., Xiao, L., Hruza, A., Harris, J., Tiscia, H.E., Chang, R.K., Embrey, M.W., McCauley, J.A., Li, W., Lin, S., Liu, H., Dai, X., Baptista, M., Agnihotri, G., Columbus, J., Mei, H., Poirier, M., Zhou, X., Lin, Y., Yin, Z., Sanders, J.M., Drolet, R.E., Kern, J.T., Kennedy, M.E., Parker, E.M., Stamford, A.W., Nargund, R., Miller, M.W.
Deposit date:2016-12-08
Release date:2017-03-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J. Med. Chem., 60, 2017
4QQN
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PROTEIN ARGININE METHYLTRANSFERASE 3 IN COMPLEX WITH COMPOUND MTV044246
Descriptor:PRMT3 protein, 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, GLYCEROL, ...
Authors:Dong, A., Dobrovetsky, E., Tempel, W., He, H., Zhao, K., Smil, D., Landon, M., Luo, X., Chen, Z., Dai, M., Yu, Z., Lin, Y., Zhang, H., Zhao, K., Schapira, M., Brown, P.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-09-17
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).
J. Med. Chem., 61, 2018
2HGA
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SOLUTION NMR STRUCTURE OF CONSERVED PROTEIN MTH1368, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET TT821A
Descriptor:Conserved protein MTH1368
Authors:Liu, G., Lin, Y., Parish, D., Shen, Y., Sukumaran, D., Yee, A., Semesi, A., Arrowsmith, C., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-06-26
Release date:2006-07-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of Conserved protein MTH1368, Northeast Structural Genomics Consortium Target TT821A
TO BE PUBLISHED
3JBB
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CHARACTERIZATION OF RED-SHIFTED PHYCOBILIPROTEIN COMPLEXES ISOLATED FROM THE CHLOROPHYLL F-CONTAINING CYANOBACTERIUM HALOMICRONEMA HONGDECHLORIS
Descriptor:allophycocyanin subunit alpha-B, allophycocyanin beta chain, PHYCOCYANOBILIN, ...
Authors:Li, Y., Lin, Y., Garvey, C., Birch, D., Corkery, R.W., Loughlin, P.C., Scheer, H., Willows, R.D., Chen, M.
Deposit date:2015-08-26
Release date:2015-11-11
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (26 Å)
Cite:Characterization of red-shifted phycobilisomes isolated from the chlorophyll f-containing cyanobacterium Halomicronema hongdechloris.
Biochim.Biophys.Acta, 1857, 2015
3SHB
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CRYSTAL STRUCTURE OF PHD DOMAIN OF UHRF1
Descriptor:E3 ubiquitin-protein ligase UHRF1, Histone H3 peptide, ZINC ION
Authors:Hu, L., Li, Z., Wang, P., Lin, Y., Xu, Y.
Deposit date:2011-06-16
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2.
Cell Res., 2011
4N7R
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CRYSTAL STRUCTURE OF ARABIDOPSIS GLUTAMYL-TRNA REDUCTASE IN COMPLEX WITH ITS BINDING PROTEIN
Descriptor:Glutamyl-tRNA reductase 1, chloroplastic, Genomic DNA, ...
Authors:Zhao, A., Fang, Y., Lin, Y., Gong, W., Liu, L.
Deposit date:2013-10-16
Release date:2014-05-14
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein
Proc.Natl.Acad.Sci.USA, 111, 2014
2OEY
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SOLUTION STRUCTURE OF A DESIGNED SPIROCYCLIC HELICAL LIGAND BINDING AT A TWO-BASE BULGE SITE IN DNA
Descriptor:DNA (25-MER), (1R,3A'S,10'S,10A'R)-7-METHOXY-2-OXO-10',10A'-DIHYDRO-2H,3A'H-SPIRO[NAPHTHALENE-1,3'-PENTALENO[1,2-B]NAPHTHALEN]-10'-YL 2,6-DIDEOXY-2-(METHYLAMINO)-ALPHA-D-GALACTOPYRANOSIDE
Authors:Zhang, N., Lin, Y., Xiao, Z., Jones, G.B., Goldberg, I.H.
Deposit date:2007-01-01
Release date:2007-04-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of a Designed Spirocyclic Helical Ligand Binding at a Two-Base Bulge Site in DNA.
Biochemistry, 46, 2007
1BH0
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STRUCTURE OF A GLUCAGON ANALOG
Descriptor:GLUCAGON
Authors:Sturm, N.S., Lin, Y., Burley, S.K., Krstenansky, J.L., Ahn, J.-M., Azizeh, B.Y., Trivedi, D., Hruby, V.J.
Deposit date:1998-06-11
Release date:1998-11-04
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.
J.Med.Chem., 41, 1998
1DUJ
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SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2
Descriptor:SPINDLE ASSEMBLY CHECKPOINT PROTEIN
Authors:Luo, X., Fang, G., Coldiron, M., Lin, Y., Yu, H.
Deposit date:2000-01-17
Release date:2000-03-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.
Nat.Struct.Biol., 7, 2000
1RHT
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24-MER RNA HAIRPIN COAT PROTEIN BINDING SITE FOR BACTERIOPHAGE R17 (NMR, MINIMIZED AVERAGE STRUCTURE)
Descriptor:RNA (5'-R(P*GP*GP*GP*AP*CP*UP*GP*AP*CP*GP*AP*UP*CP*AP*CP*GP*CP*AP*GP*UP*CP*UP*AP*U)-3')
Authors:Borer, P.N., Lin, Y., Wang, S., Roggenbuck, M.W., Gott, J.M., Uhlenbeck, O.C., Pelczer, I.
Deposit date:1995-03-03
Release date:1995-06-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Proton NMR and structural features of a 24-nucleotide RNA hairpin.
Biochemistry, 34, 1995
2GHV
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CRYSTAL STRUCTURE OF SARS SPIKE PROTEIN RECEPTOR BINDING DOMAIN
Descriptor:Spike glycoprotein
Authors:Hwang, W.C., Lin, Y., Santelli, E., Sui, J., Jaroszewski, L., Stec, B., Farzan, M., Marasco, W.A., Liddington, R.C.
Deposit date:2006-03-27
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R.
J.Biol.Chem., 281, 2006
2GHW
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CRYSTAL STRUCTURE OF SARS SPIKE PROTEIN RECEPTOR BINDING DOMAIN IN COMPLEX WITH A NEUTRALIZING ANTIBODY, 80R
Descriptor:Spike glycoprotein, anti-sars scFv antibody, 80R, ...
Authors:Hwang, W.C., Lin, Y., Santelli, E., Sui, J., Jaroszewski, L., Stec, B., Farzan, M., Marasco, W.A., Liddington, R.C.
Deposit date:2006-03-27
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R.
J.Biol.Chem., 281, 2006