Author results

5ZH0
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CRYSTAL STRUCTURES OF ENDO-BETA-1,4-XYLANASE II
分子名称:Endo-1,4-beta-xylanase 2, GLYCEROL, IODIDE ION
著者Zhang, X., Wan, Q., Li, Z.
登録日2018-03-10
公開日2019-03-13
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献Crystal Structures of Endo-beta-1,4-xylanase II
To be published
4J8C
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CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OF HSC70-INTERACTING PROTEIN
分子名称:Hsc70-interacting protein, GLYCEROL
著者Li, Z., Bracher, A.
登録日2013-02-14
公開日2013-07-03
最終更新日2018-06-06
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle.
Nat.Struct.Mol.Biol., 20, 2013
6EKG
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CRYSTAL STRUCTURE OF AN ARCHAEAL CHEY FROM METHANOCCOCUS MARIPALUDIS
分子名称:Chemotaxis protein CheY, MAGNESIUM ION
著者Altegoer, F., Bange, G.
登録日2017-09-26
公開日2018-01-31
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Structure and function of the archaeal response regulator CheY.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6IQ9
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CRYSTAL STRUCTURE OF ALINE4, A SGNH-HYDROLASE FAMILY ESTERASE
分子名称:SGNH-hydrolase family esterase, CADMIUM ION, ACETATE ION
著者Li, Z., Li, J.
登録日2018-11-06
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献C-terminal swapped dimers revealed a new catalytic mechanism of SGNH-hydrolase family esterases
To Be Published
5OOH
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HUMAN BILIVERDIN IX BETA REDUCTASE: NADP/ERYTHROSIN EXTRA BLUISH TERNARY COMPLEX
分子名称:Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ...
著者Manso, J.A., Pereira, P.J.B.
登録日2017-08-07
公開日2018-03-07
最終更新日2018-04-25
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献In silicoand crystallographic studies identify key structural features of biliverdin IX beta reductase inhibitors having nanomolar potency.
J. Biol. Chem., 293, 2018
5ZF3
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CRYSTAL STRUCTURES OF ENDO-BETA-1,4-XYLANASE II COMPLEXED WITH XYLOTRIOSE
分子名称:Endo-1,4-beta-xylanase 2, BETA-D-XYLOPYRANOSE, GLYCEROL, ...
著者Zhang, X., Wan, Q., Li, Z.
登録日2018-03-02
公開日2019-03-06
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal Structures of Endo-beta-1,4-xylanase II Complexed with Xylotriose
To be published
6BFP
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BOVINE TRYPSIN BOUND TO POTENT INHIBITOR
分子名称:Cationic trypsin, CALCIUM ION, 3-{2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl}-6-[(cyclopropylmethyl)carbamoyl]pyridine-2-carboxylic acid
著者Partridge, J.R., Choy, R.M.
登録日2017-10-26
公開日2018-10-31
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (1.292 Å)
主引用文献Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition.
J.Struct.Biol., 206, 2019
5EXH
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CRYSTAL STRUCTURE OF MTET3-CXXC DOMAIN IN COMPLEX WITH 5-CARBOXYLCYTOSINE DNA AT 1.3 ANGSTROMS RESOLUTION.
分子名称:DNA (5'-D(*GP*AP*AP*TP*CP*(1CC)P*GP*GP*AP*TP*TP*C)-3'), Methylcytosine dioxygenase TET3, ZINC ION
著者Song, J.
登録日2015-11-23
公開日2016-02-03
最終更新日2016-02-10
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.
Cell Rep, 14, 2016
5L0V
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HUMAN POGLUT1 IN COMPLEX WITH 2F-GLUCOSE MODIFIED EGF(+) AND UDP
分子名称:Protein O-glucosyltransferase 1, EGF(+), N-ACETYL-D-GLUCOSAMINE, ...
著者Li, Z., Rini, J.M.
登録日2016-07-28
公開日2017-08-09
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (1.305 Å)
主引用文献Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).
Nat Commun, 8, 2017
5KXH
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MOUSE POFUT1 IN COMPLEX WITH MOUSE FACTOR VII EGF1 AND GDP
分子名称:GDP-fucose protein O-fucosyltransferase 1, Coagulation factor VII, N-ACETYL-D-GLUCOSAMINE, ...
著者Li, Z., Rini, J.M.
登録日2016-07-20
公開日2017-05-17
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
Nat. Chem. Biol., 13, 2017
5OOG
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HUMAN BILIVERDIN IX BETA REDUCTASE: NADP/PHLOXINE B TERNARY COMPLEX
分子名称:Flavin reductase (NADPH), Phloxine B, GLYCEROL, ...
著者Manso, J.A., Pereira, P.J.B.
登録日2017-08-07
公開日2018-03-07
最終更新日2018-04-25
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献In silicoand crystallographic studies identify key structural features of biliverdin IX beta reductase inhibitors having nanomolar potency.
J. Biol. Chem., 293, 2018
5UJC
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CRYSTAL STRUCTURE OF A C.ELEGANS B12-TRAFFICKING PROTEIN CBLC, A HUMAN MMACHC HOMOLOGUE
分子名称:MMACHC-like protein, CO-METHYLCOBALAMIN, L(+)-TARTARIC ACID, ...
著者Li, Z., Shanmuganathan, A., Ruetz, M., Yamada, K., Lesniak, N.A., Krautler, B., Brunold, T.C., Banerjee, R., Koutmos, M.
登録日2017-01-17
公開日2017-05-03
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Coordination chemistry controls the thiol oxidase activity of the B12-trafficking protein CblC.
J. Biol. Chem., 292, 2017
6TYY
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HEDGEHOG AUTOPROCESSING MUTANT D46H
分子名称:Protein hedgehog
著者Li, H., Li, Z., Wang, C., Callahan, B.P.
登録日2019-08-09
公開日2019-11-20
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing.
J.Am.Chem.Soc., 2019
4OGN
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHBITOR COMPOUND 3
分子名称:E3 ubiquitin-protein ligase Mdm2, 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid, SULFATE ION
著者Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
登録日2014-01-16
公開日2014-04-02
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.377 Å)
主引用文献Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
5HXF
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CRYSTAL STRUCTURE OF 3C PROTEASE FROM A MILD HUMAN ENTEROVIRUS 71 IN COMPLEX WITH RUPINTRIVIR
分子名称:3C protease, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, SULFATE ION
著者Li, B., Yuan, Z., Qin, L., Gu, L.
登録日2016-01-30
公開日2017-02-15
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Crystal structure of 3C protease from a mild Human enterovirus 71 in complex with rupintrivir
To Be Published
5U81
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ACID CERAMIDASE (ASAH1, ACDASE) FROM NAKED MOLE RAT, CYS143ALA, UNCLEAVED
分子名称:Acid ceramidase isoform b, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Gebai, A., Gorelik, A., Illes, K., Nagar, B.
登録日2016-12-13
公開日2018-03-28
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural basis for the activation of acid ceramidase.
Nat Commun, 9, 2018
5ZU6
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A CBM32 DERIVED FROM ALGINATE LYASE B (ALYB-OU02)
分子名称:CBM32 domain, SODIUM ION
著者Liu, W., Lyu, Q., Zhang, K.
登録日2018-05-07
公開日2018-06-20
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural and biochemical characterization of a multidomain alginate lyase reveals a novel role of CBM32 in CAZymes
Biochim. Biophys. Acta, 1862, 2018
5K08
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RECA MINI INTEIN-ZEISE'S SALT COMPLEX
分子名称:RecA mini intein, Trichloro(ethene)platinate(II), SULFATE ION, ...
著者Li, Z., Li, H.M.
登録日2016-05-17
公開日2016-09-21
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Structural insights into protein splicing inhibition by platinum therapeutics as potential anti-microbials
To be published
5TJX
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STRUCTURE OF HUMAN PLASMA KALLIKREIN
分子名称:Plasma kallikrein, (8E)-3-amino-1-methyl-15-[(1H-pyrazol-1-yl)methyl]-7,10,11,12,24,25-hexahydro-6H,18H,23H-19,22-(metheno)pyrido[4,3-j][1,9,13,17,18]benzodioxatriazacyclohenicosin-23-one, PHOSPHATE ION
著者Partridge, J.R., Choy, R.M., Li, Z.
登録日2016-10-05
公開日2016-12-21
最終更新日2017-03-01
実験手法X-RAY DIFFRACTION (1.408 Å)
主引用文献Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors.
ACS Med Chem Lett, 8, 2017
4WT2
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CO-CRYSTAL STRUCTURE OF MDM2 IN COMPLEX WITH AM-7209
分子名称:E3 ubiquitin-protein ligase Mdm2, 4-({[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl}amino)-2-methoxybenzoic acid, SULFATE ION
著者Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
登録日2014-10-30
公開日2014-12-03
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction.
J.Med.Chem., 57, 2014
5EP2
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QUORUM-SENSING SIGNAL INTEGRATOR LUXO - CATALYTIC DOMAIN IN COMPLEX WITH AZAU INHIBITOR
分子名称:Putative repressor protein luxO, 2,2-dimethylpropyl 2-[[3,5-bis(oxidanylidene)-2~{H}-1,2,4-triazin-6-yl]sulfanyl]ethanoate, ACETATE ION
著者Shah, T., Selcuk, H.B., Jeffrey, P.D., Hughson, F.M.
登録日2015-11-11
公開日2016-04-20
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.421 Å)
主引用文献Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.
Plos Biol., 14, 2016
5L0T
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HUMAN POGLUT1 IN COMPLEX WITH EGF(+) AND UDP
分子名称:Protein O-glucosyltransferase 1, EGF(+), N-ACETYL-D-GLUCOSAMINE, ...
著者Li, Z., Rini, J.M.
登録日2016-07-28
公開日2017-08-09
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).
Nat Commun, 8, 2017
5L0S
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HUMAN POGLUT1 IN COMPLEX WITH FACTOR VII EGF1 AND UDP
分子名称:Protein O-glucosyltransferase 1, Coagulation factor VII, N-ACETYL-D-GLUCOSAMINE, ...
著者Li, Z., Rini, J.M.
登録日2016-07-28
公開日2017-08-09
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).
Nat Commun, 8, 2017
5KY2
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MOUSE POFUT1 IN COMPLEX WITH O-GLUCOSYLATED MOUSE FACTOR VII EGF1 AND GDP
分子名称:GDP-fucose protein O-fucosyltransferase 1, Coagulation factor VII, N-ACETYL-D-GLUCOSAMINE, ...
著者Li, Z., Rini, J.M.
登録日2016-07-20
公開日2017-05-17
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
Nat. Chem. Biol., 13, 2017
5KY4
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MOUSE POFUT1 IN COMPLEX WITH MOUSE NOTCH1 EGF26 AND GDP
分子名称:GDP-fucose protein O-fucosyltransferase 1, Neurogenic locus notch homolog protein 1, N-ACETYL-D-GLUCOSAMINE, ...
著者Li, Z., Rini, J.M.
登録日2016-07-21
公開日2017-05-17
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (1.472 Å)
主引用文献Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
Nat. Chem. Biol., 13, 2017