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4G0U
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMSACRINE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0V
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND MITOXANTRONE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0W
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMETANTRONE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4J3N
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2013-02-06
Release date:2013-10-02
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
3QX3
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND ETOPOSIDE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Farh, L., Lin, L.Y., Lin, T.S., Yu, Y.J., Yen, T.J., Chiang, C.W., Chan, N.L.
Deposit date:2011-03-01
Release date:2011-07-06
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.162 Å)
Cite:Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Science, 333, 2011
5GWI
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STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873R
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Chen, S.F., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.737 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWJ
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STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873S
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Chen, S.F., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.566 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWK
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HUMAN TOPOISOMERASE IIALPHA IN COMPLEX WITH DNA AND ETOPOSIDE
Descriptor:DNA topoisomerase 2-alpha, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.152 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017