Author results

3E5Q
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UNBOUND OXIDISED CPRK
Descriptor:Cyclic nucleotide-binding protein
Authors:Levy, C.
Deposit date:2008-08-14
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator
Mol.Microbiol., 70, 2008
3E5U
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OCPA COMPLEXED CPRK (C200S)
Descriptor:Cyclic nucleotide-binding protein, (3-CHLORO-4-HYDROXYPHENYL)ACETIC ACID, PHOSPHATE ION, ...
Authors:Levy, C.
Deposit date:2008-08-14
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator
Mol.Microbiol., 70, 2008
3E5X
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OCPA COMPLEXED CPRK
Descriptor:Cyclic nucleotide-binding protein, (3-CHLORO-4-HYDROXYPHENYL)ACETIC ACID
Authors:Levy, C.
Deposit date:2008-08-14
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator
Mol.Microbiol., 70, 2008
3E6B
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OCPA COMPLEXED CPRK (C200S)
Descriptor:Cyclic nucleotide-binding protein, (3-CHLORO-4-HYDROXYPHENYL)ACETIC ACID
Authors:Levy, C.
Deposit date:2008-08-15
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator
Mol.Microbiol., 70, 2008
3E6C
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CPRK OCPA DNA COMPLEX
Descriptor:Cyclic nucleotide-binding protein, DNA (5'-D(P*DGP*DCP*DAP*DTP*DTP*DAP*DAP*DCP*DAP*DTP*DGP*DCP*DC)-3'), DNA (5'-D(P*DGP*DGP*DCP*DAP*DTP*DGP*DTP*DTP*DAP*DAP*DTP*DGP*DC)-3'), ...
Authors:Levy, C.
Deposit date:2008-08-15
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator
Mol.Microbiol., 70, 2008
3E6D
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CRYSTAL STRUCTURE OF CPRK C200S
Descriptor:Cyclic nucleotide-binding protein
Authors:Levy, C.
Deposit date:2008-08-15
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator
Mol.Microbiol., 70, 2008
2H6C
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CRYSTAL STRUCTURE OF REDUCED CPRK IN ABSENCE OF ANY LIGAND
Descriptor:ChloroPhenol Reduction gene K
Authors:Levy, C., Leys, D.
Deposit date:2006-05-31
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:CprK Crystal Structures Reveal Mechanism for Transcriptional Control of Halorespiration.
J.Biol.Chem., 281, 2006
2VEF
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DIHYDROPTEROATE SYNTHASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:DIHYDROPTEROATE SYNTHASE, PHOSPHATE ION
Authors:Derrick, J.P., Levy, C.
Deposit date:2007-10-24
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dihydropteroate Synthase from Streptococcus Pneumoniae: Structure, Ligand Recognition and Mechanism of Sulfonamide Resistance.
Biochem.J., 412, 2008
2VEG
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DIHYDROPTEROATE SYNTHASE FROM STREPTOCOCCUS PNEUMONIAE: COMPLEX WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN MONOPHOSPHATE
Descriptor:DIHYDROPTEROATE SYNTHASE, PTERIN-6-YL-METHYL-MONOPHOSPHATE, PHOSPHATE ION
Authors:Derrick, J., Levy, C.
Deposit date:2007-10-24
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dihydropteroate Synthase from Streptococcus Pneumoniae: Structure, Ligand Recognition and Mechanism of Sulfonamide Resistance.
Biochem.J., 412, 2008
3IA4
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MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX)
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE
Authors:Levy, C.
Deposit date:2009-07-13
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted?
Chembiochem, 10, 2009
4GU5
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STRUCTURE OF FULL-LENGTH DROSOPHILA CRYPTOCHROME
Descriptor:Cryptochrome-1, MAGNESIUM ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Zoltowski, B.D., Vaidya, A.T., Top, D., Widom, J., Young, M.W., Levy, C., Jones, A.R., Scrutton, N.S., Leys, D., Crane, B.R.
Deposit date:2012-08-29
Release date:2012-09-26
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Updated structure of Drosophila cryptochrome.
Nature, 495, 2013
5FHQ
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CRYSTAL STRUCTURE OF (WT) RAT CATECHOL-O-METHYLTRANSFERASE IN COMPLEX WITH ADOMET AND 3,5-DINITROCATECHOL (DNC)
Descriptor:Catechol O-methyltransferase, S-ADENOSYLMETHIONINE, 3,5-DINITROCATECHOL, ...
Authors:Levy, C.
Deposit date:2015-12-22
Release date:2016-02-03
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase.
Angew.Chem.Int.Ed.Engl., 55, 2016
5FHR
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CRYSTAL STRUCTURE OF Y200L MUTANT OF RAT CATECHOL-O-METHYLTRANSFERASE IN COMPLEX WITH ADOMET AND 3,5-DINITROCATECHOL
Descriptor:Catechol O-methyltransferase, 3,5-DINITROCATECHOL, MAGNESIUM ION, ...
Authors:Levy, C.
Deposit date:2015-12-22
Release date:2016-02-03
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase.
Angew.Chem.Int.Ed.Engl., 55, 2016
5HY5
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CRYSTAL STRUCTURE OF A TRYPTOPHAN 6-HALOGENASE (STTH) FROM STREPTOMYCES TOXYTRICINI
Descriptor:Tryptophan 6-halogenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION
Authors:Levy, C.
Deposit date:2016-02-01
Release date:2016-02-17
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase.
Chembiochem, 17, 2016
5L57
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CRYSTAL STRUCTURE OF ISO-CITRATE DEHYDROGENASE R132H IN COMPLEX WITH A NOVEL INHIBITOR (COMPOUND 13A)
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1~{R},5~{S})-3-[6-(3-methylbutoxy)-5-[[(1~{R},3~{S})-5-oxidanyl-2-adamantyl]carbamoyl]pyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
Authors:Levy, C.
Deposit date:2016-05-28
Release date:2016-12-14
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J. Med. Chem., 59, 2016
5L58
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CRYSTAL STRUCTURE OF ISO-CITRATE DEHYDROGENASE 1 [IDH1 (R132H)] IN COMPLEX WITH A NOVEL INHIBITOR (COMPOUND 2)
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(3~{R})-1-[6-cyclohexylsulfanyl-5-[[(1~{R},3~{S})-5-oxidanyl-2-adamantyl]carbamoyl]pyridin-2-yl]pyrrolidin-3-yl]ethanoic acid
Authors:Levy, C.
Deposit date:2016-05-28
Release date:2016-12-14
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J. Med. Chem., 59, 2016
5LM1
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CRYSTAL STRUCTURE OF HD-PTP PHOSPHATASE IN COMPLEX WITH UBAP1
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, UBAP-1
Authors:Levy, C.
Deposit date:2016-07-28
Release date:2016-11-30
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.
Structure, 24, 2016
5LM2
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CRYSTAL STRUCTURE OF HD-PTP PHOSPHATASE
Descriptor:Tyrosine-protein phosphatase non-receptor type 23
Authors:Levy, C.
Deposit date:2016-07-28
Release date:2016-11-30
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.
Structure, 24, 2016
5MJY
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (SARA COMPLEX STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Zinc finger FYVE domain-containing protein 9
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MJZ
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (APO STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.867 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MK0
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (ENDOFIN PEPTIDE COMPLEX)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Zinc finger FYVE domain-containing protein 16
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.765 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MK1
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (CHMP4A PEPTIDE COMPLEX STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Charged multivesicular body protein 4a
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MK2
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (CHMP4B PEPTIDE COMPLEX STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Charged multivesicular body protein 4b
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MK3
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO 1 DOMAIN (CHMP4C PEPTIDE COMPLEX STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Charged multivesicular body protein 4c
Authors:Levy, C.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MHJ
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ICP4 DNA-BINDING DOMAIN, LACKING INTRINSICALLY DISORDERED REGION, IN COMPLEX WITH 12MER DNA DUPLEX FROM ITS OWN PROMOTER
Descriptor:Major viral transcription factor ICP4, DNA (5'-D(P*CP*GP*AP*TP*CP*GP*TP*CP*C)-3'), ACETIC ACID, ...
Authors:Tunnicliffe, R.B., Lockhart-Cairns, M.P., Levy, C., Mould, P., Jowitt, T.A., Sito, H., Baldock, C., Sandri-Goldin, R.M., Golovanov, A.P.
Deposit date:2016-11-24
Release date:2017-05-24
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.117 Å)
Cite:The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.
Nucleic Acids Res., 45, 2017