Author results

5KBZ
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STRUCTURE OF THE PKSA PRODUCT TEMPLATE DOMAIN IN COMPLEX WITH A PHOSPHOPANTETHEINE MIMETIC
Descriptor:Noranthrone synthase, (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate
Authors:Tsai, S.C., Burkart, M.D., Townsend, C.A., Barajas, J.F., Shakya, G., Topper, C.L., Moreno, G., Jackson, D.R., Rivera, H., La Clair, J.J., Vagstad, A.
Deposit date:2016-06-03
Release date:2017-05-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3Q
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 1
Descriptor:Peroxisome proliferator-activated receptor delta, 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(propan-2-yl)amino]methyl}phenoxy)hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3R
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 2
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-[2-({[4-(furan-2-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3S
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 3
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({[4-(furan-3-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3T
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 4
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({(propan-2-yl)[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3U
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 5
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({cyclopentyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3V
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 6
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-[2-({cyclopentyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3W
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 7
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(cyclopropyl)amino]methyl}phenoxy)hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3X
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 8
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({cyclopropyl[4-(pyridin-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3Y
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 9
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-[2-({cyclopropyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3Z
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 10
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({cyclopropyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U40
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 15
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({benzyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, DI(HYDROXYETHYL)ETHER, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U41
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 16
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({benzyl[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, DI(HYDROXYETHYL)ETHER, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U42
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 11
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-(2-{[cyclopropyl(3'-methoxy[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U43
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 12
Descriptor:Peroxisome proliferator-activated receptor delta, 6-(2-{[cyclopropyl(4'-methoxy[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U44
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 13
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U45
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 14
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-(2-{[cyclopropyl(3'-fluoro[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U46
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH GW501516
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6CJN
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CRYSTAL STRUCTURE OF CHALCONE ISOMERASE FROM MEDICAGO SATIVA WITH THE G95T MUTATION
Descriptor:Chalcone--flavonone isomerase 1, SULFATE ION
Authors:Burke, J.R., La Clair, J.J., Philippe, R.N., Pabis, A., Jez, J.M., Cortina, G., Kaltenbach, M., Bowman, M.E., Woods, K.B., Nelson, A.T., Tawfik, D.S., Kamerlin, S.C.L., Noel, J.P.
Deposit date:2018-02-26
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dynamics and Bifunctional Substrate Activation by an Arginine Drive Catalysis in Plant Chalcone Isomerases
To Be Published
6CJO
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CRYSTAL STRUCTURE OF CHALCONE ISOMERASE FROM MEDICAGO SATIVA WITH THE G95S MUTATION.
Descriptor:Chalcone--flavonone isomerase 1, SULFATE ION
Authors:Burke, J.R., La Clair, J.J., Philippe, R.N., Pabis, A., Jez, J.M., Cortina, G., Kaltenbach, M., Bowman, M.E., Woods, K.B., Nelson, A.T., Tawfik, D.S., Kamerlin, S.C.L., Noel, J.P.
Deposit date:2018-02-26
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dynamics and Bifunctional Substrate Activation by an Arginine Drive Catalysis in Plant Chalcone Isomerases
To Be Published
4JYM
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CRYSTAL STRUCTURE OF KAI2 IN COMPLEX WITH 3-METHYL-2H-FURO[2,3-C]PYRAN-2-ONE
Descriptor:Hydrolase, alpha/beta fold family protein, 3-methyl-2H-furo[2,3-c]pyran-2-one
Authors:Guo, Y., Zheng, Z., Noel, J.P.
Deposit date:2013-03-30
Release date:2013-05-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Smoke-derived karrikin perception by the alpha/beta-hydrolase KAI2 from Arabidopsis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JYP
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CRYSTAL STRUCTURE OF KAI2 APO FORM
Descriptor:Hydrolase, alpha/beta fold family protein
Authors:Guo, Y., Zheng, Z., Noel, J.P.
Deposit date:2013-03-31
Release date:2013-05-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Smoke-derived karrikin perception by the alpha/beta-hydrolase KAI2 from Arabidopsis.
Proc.Natl.Acad.Sci.USA, 110, 2013