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2I3Z
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RAT DPP-IV WITH XANTHINE MIMETIC INHIBITOR #7
Descriptor:Dipeptidyl peptidase 4 (Dipeptidyl peptidase IV) (DPP IV), 2-[(3S)-3-AMINOPIPERIDIN-1-YL]-1-(2-CYANOBENZYL)-5-METHYL-4,6-DIOXO-3,4,5,6-TETRAHYDROPYRROLO[3,4-D]IMIDAZOL-1-IUM
Authors:Kurukulasuriya, R., Rohde, J.J., Szczepankiewicz, B.G., Basha, F., Lai, C., Winn, M., Stewart, K.D., Longenecker, K.L., Lubben, T.W., Ballaron, S.J., Sham, H.L., VonGeldern, T.W.
Deposit date:2006-08-21
Release date:2006-12-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
6PU7
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HUMAN IDO1 IN COMPLEX WITH COMPOUND 17 (N-{2-[(4-{N-[(7S)-4-FLUOROBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL]-N'-HYDROXYCARBAMIMIDOYL}-1,2,5-OXADIAZOL-3-YL)SULFANYL]ETHYL}ACETAMIDE)
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-{2-[(4-{N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N'-hydroxycarbamimidoyl}-1,2,5-oxadiazol-3-yl)sulfanyl]ethyl}acetamide
Authors:Lesburg, C.A.
Deposit date:2019-07-17
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.
Acs Med.Chem.Lett., 10, 2019