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2BVC
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH A TRANSITION STATE MIMIC
Descriptor:GLUTAMINE SYNTHETASE 1, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Krajewski, W.W., Jones, T.A., Mowbray, S.L.
Deposit date:2005-06-23
Release date:2005-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Mycobacterium Tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights.
Proc.Natl.Acad.Sci.USA, 102, 2005
2UU7
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CRYSTAL STRUCTURE OF APO GLUTAMINE SYNTHETASE FROM DOG (CANIS FAMILIARIS)
Descriptor:GLUTAMINE SYNTHETASE, MAGNESIUM ION, CHLORIDE ION
Authors:Krajewski, W.W., Jones, T.A., Mowbray, S.L.
Deposit date:2007-02-28
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design.
J.Mol.Biol., 375, 2008
4CEH
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CRYSTAL STRUCTURE OF ADDAB WITH A FORKED DNA SUBSTRATE
Descriptor:ATP-DEPENDENT HELICASE/NUCLEASE SUBUNIT A, ATP-DEPENDENT HELICASE/DEOXYRIBONUCLEASE SUBUNIT B, DNA, ...
Authors:Krajewski, W.W., Wilkinson, M., Fu, X., Cronin, N.B., Wigley, D.
Deposit date:2013-11-11
Release date:2014-03-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural Basis for Translocation by Addab Helicase-Nuclease and its Arrest at Chi Sites.
Nature, 508, 2014
4CEI
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CRYSTAL STRUCTURE OF ADPNP-BOUND ADDAB WITH A FORKED DNA SUBSTRATE
Descriptor:ATP-DEPENDENT HELICASE/NUCLEASE SUBUNIT A, ATP-DEPENDENT HELICASE/DEOXYRIBONUCLEASE SUBUNIT B, DNA, ...
Authors:Krajewski, W.W., Wilkinson, M., Fu, X., Cronin, N.B., Wigley, D.
Deposit date:2013-11-11
Release date:2014-03-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Translocation by Addab Helicase-Nuclease and its Arrest at Chi Sites.
Nature, 508, 2014
4CEJ
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CRYSTAL STRUCTURE OF ADDAB-DNA-ADPNP COMPLEX AT 3 ANGSTROM RESOLUTION
Descriptor:ATP-DEPENDENT HELICASE/NUCLEASE SUBUNIT A, ATP-DEPENDENT HELICASE/DEOXYRIBONUCLEASE SUBUNIT B, DNA, ...
Authors:Krajewski, W.W., Wilkinson, M., Fu, X., Cronin, N.B., Wigley, D.
Deposit date:2013-11-11
Release date:2014-03-12
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Translocation by Addab Helicase-Nuclease and its Arrest at Chi Sites.
Nature, 508, 2014
5NGF
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE COVALENT INHIBITOR, FT827
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide, 1,2-ETHANEDIOL
Authors:Krajewski, W.W., Turnbull, A.P., Ioannidis, S., Kessler, B.M., Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
2WGS
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH A PURINE ANALOGUE INHIBITOR.
Descriptor:GLUTAMINE SYNTHETASE 1, 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION
Authors:Nilsson, M.T., Krajewski, W.W., Jones, T.A., Mowbray, S.L.
Deposit date:2009-04-27
Release date:2009-09-01
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.
J.Mol.Biol., 393, 2009
2WHI
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH A PURINE ANALOGUE INHIBITOR AND L-METHIONINE-S- SULFOXIMINE PHOSPHATE.
Descriptor:GLUTAMINE SYNTHETASE 1, 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, MAGNESIUM ION, ...
Authors:Nilsson, M.T., Krajewski, W.W., Jones, T.A., Mowbray, S.L.
Deposit date:2009-05-05
Release date:2009-09-01
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.
J.Mol.Biol., 393, 2009
5NGE
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE NON-COVALENT INHIBITOR, FT671
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
Authors:Turnbull, A.P., Krajewski, W.W., Ioannidis, S., Kessler, B.M., Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
2OJW
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CRYSTAL STRUCTURE OF HUMAN GLUTAMINE SYNTHETASE IN COMPLEX WITH ADP AND PHOSPHATE
Descriptor:Glutamine synthetase, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Karlberg, T., Uppenberg, J., Arrowsmith, C., Berglund, H., Busam, R.D., Collins, R., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hallberg, B.M., Hammarstrom, M., Hogbom, M., Johansson, I., Kotenyova, T., Moche, M., Nilsson, M.E., Nordlund, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Wallden, K., Weigelt, J., Holmberg-Schiavone, L., Structural Genomics Consortium (SGC)
Deposit date:2007-01-15
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375, 2008
2QC8
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CRYSTAL STRUCTURE OF HUMAN GLUTAMINE SYNTHETASE IN COMPLEX WITH ADP AND METHIONINE SULFOXIMINE PHOSPHATE
Descriptor:Glutamine synthetase, MANGANESE (II) ION, CHLORIDE ION, ...
Authors:Karlberg, T., Lehtio, L., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hogbom, M., Johansson, I., Kallas, A., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Holmberg-Schiavone, L., Structural Genomics Consortium (SGC)
Deposit date:2007-06-19
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375, 2008
3U44
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CRYSTAL STRUCTURE OF ADDAB-DNA COMPLEX
Descriptor:ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/deoxyribonuclease subunit B, DNA (36-MER), ...
Authors:Saikrishnan, K., Krajewski, W., Wigley, D.
Deposit date:2011-10-07
Release date:2012-03-21
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex.
Embo J., 31, 2012
3U4Q
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STRUCTURE OF ADDAB-DNA COMPLEX AT 2.8 ANGSTROMS
Descriptor:ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/deoxyribonuclease subunit B, DNA (27-MER), ...
Authors:Saikrishnan, K., Krajewski, W., Wigley, D.
Deposit date:2011-10-10
Release date:2012-03-21
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex.
Embo J., 31, 2012
3ZXR
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH TRI-SUBSTITUTED IMIDAZOLE INHIBITOR (3-(2-TERT-BUTYL- 5-(PYRIDIN-4-YL)-1H-IMIDAZOL-4-YL)QUINOLINE) AND L-METHIONINE-S- SULFOXIMINE PHOSPHATE.
Descriptor:GLUTAMINE SYNTHETASE 1, 3-(2-TERT-BUTYL-5-(PYRIDIN-4-YL)-1H-IMIDAZOL-4-YL)QUINOLINE, MAGNESIUM ION, ...
Authors:Nilsson, M.T., Mowbray, S.L.
Deposit date:2011-08-15
Release date:2012-04-04
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors.
J.Med.Chem., 55, 2012
3ZXV
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH TRI-SUBSTITUTED IMIDAZOLE INHIBITOR (4-(2-TERT-BUTYL- 4-(6-METHOXYNAPHTHALEN-2-YL)-1H-IMIDAZOL-5-YL)PYRIDIN-2-AMINE) AND L- METHIONINE-S-SULFOXIMINE PHOSPHATE
Descriptor:GLUTAMINE SYNTHETASE 1, 4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE, MAGNESIUM ION, ...
Authors:Nilsson, M.T., Mowbray, S.L.
Deposit date:2011-08-16
Release date:2012-04-04
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors.
J.Med.Chem., 55, 2012
4ACF
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.
Descriptor:GLUTAMINE SYNTHETASE 1, {4-[6-BROMO-3-(BUTYLAMINO)IMIDAZO[1,2-A]PYRIDIN-2-YL]PHENOXY}ACETIC ACID, MAGNESIUM ION, ...
Authors:Nilsson, M.T., Mowbray, S.L.
Deposit date:2011-12-15
Release date:2012-10-24
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis, Biological Evaluation and X-Ray Crystallographic Studies of Imidazo(1,2-A)Pyridine-Based Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors
Medchemcomm, 3, 2012