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1PXX
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CRYSTAL STRUCTURE OF DICLOFENAC BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Kiefer, J.R., Rowlinson, S.W., Prusakiewicz, J.J., Pawlitz, J.L., Kozak, K.R., Kalgutkar, A.S., Stallings, W.C., Marnett, L.J., Kurumbail, R.G.
Deposit date:2003-07-07
Release date:2003-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385.
J.Biol.Chem., 278, 2003
2OYE
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INDOMETHACIN-(R)-ALPHA-ETHYL-ETHANOLAMIDE BOUND TO CYCLOOXYGENASE-1
Descriptor:Prostaglandin G/H synthase 1, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Harman, C.A., Garavito, R.M.
Deposit date:2007-02-21
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.
J.Biol.Chem., 282, 2007
2OYU
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INDOMETHACIN-(S)-ALPHA-ETHYL-ETHANOLAMIDE BOUND TO CYCLOOXYGENASE-1
Descriptor:Prostaglandin G/H synthase 1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Harman, C.A., Garavito, R.M.
Deposit date:2007-02-23
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.
J.Biol.Chem., 282, 2007
6AY2
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STRUCTURE OF CATHB WITH COVALENTLY LINKED COMPOUND 28
Descriptor:Cathepsin B, N~1~-[(2S)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1R)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide
Authors:Kiefer, J.R., Steinbacher, S.
Deposit date:2017-09-07
Release date:2017-12-27
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J. Med. Chem., 61, 2018
6N9T
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STRUCTURE OF A PEPTIDE-BASED PHOTO-AFFINITY CROSS-LINKER WITH HERCEPTIN FC
Descriptor:Immunoglobulin G1 FC, Photo-affinity peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sadowsky, J., Ultsch, M., Vance, N., Wang, W.
Deposit date:2018-12-04
Release date:2019-01-16
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.576 Å)
Cite:Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies.
Bioconjug. Chem., 30, 2019