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1HVY
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HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND RALTITREXED, AN ANTIFOLATE DRUG, IS IN THE CLOSED CONFORMATION
分子名称:THYMIDYLATE SYNTHASE, TOMUDEX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ...
著者Phan, J., Koli, S., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.
登録日2001-01-08
公開日2001-01-31
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug
Biochemistry, 40, 2001
1HW3
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STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
分子名称:THYMIDYLATE SYNTHASE, SULFATE ION, 1,2-ETHANEDIOL
著者Phan, J., Steadman, J.D., Koli, S., Ding, W.C., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.
登録日2001-01-09
公開日2001-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
J.Biol.Chem., 276, 2001
1HW4
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STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
分子名称:THYMIDYLATE SYNTHASE, SULFATE ION, 1,2-ETHANEDIOL
著者Phan, J., Steadman, J.D., Koli, S., Ding, W.C., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.
登録日2001-01-09
公開日2001-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
J.Biol.Chem., 276, 2001