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1T84
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SOLUTION STRUCTURE OF THE WISKOTT-ALDRICH SYNDROME PROTEIN (WASP) AUTOINHIBITED CORE DOMAIN COMPLEXED WITH (S)-WISKOSTATIN, A SMALL MOLECULE INHIBITOR
Descriptor:Wiskott-Aldrich syndrome protein, (2S)-1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL
Authors:Peterson, J.R., Bickford, L.C., Morgan, D., Kim, A.S., Ouerfelli, O., Kirschner, M.W., Rosen, M.K.
Deposit date:2004-05-11
Release date:2004-07-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Nat.Struct.Mol.Biol., 11, 2004
5T0C
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STRUCTURAL BASIS FOR DYNAMIC REGULATION OF THE HUMAN 26S PROTEASOME
Descriptor:26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 3, 26S proteasome non-ATPase regulatory subunit 12, ...
Authors:Chen, S., Wu, J., Lu, Y., Ma, Y.B., Lee, B.H., Yu, Z., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2016-08-15
Release date:2016-10-19
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for dynamic regulation of the human 26S proteasome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5T0G
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STRUCTURAL BASIS FOR DYNAMIC REGULATION OF THE HUMAN 26S PROTEASOME
Descriptor:Proteasome subunit alpha type-6, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ...
Authors:Chen, S., Wu, J., Lu, Y., Ma, Y.B., Lee, B.H., Yu, Z., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2016-08-16
Release date:2016-10-19
Last modified:2016-11-30
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural basis for dynamic regulation of the human 26S proteasome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5T0H
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STRUCTURAL BASIS FOR DYNAMIC REGULATION OF THE HUMAN 26S PROTEASOME
Descriptor:26S protease regulatory subunit 7, 26S protease regulatory subunit 4, 26S protease regulatory subunit 8, ...
Authors:Chen, S., Wu, J., Lu, Y., Ma, Y.B., Lee, B.H., Yu, Z., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2016-08-16
Release date:2016-10-19
Last modified:2016-11-30
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Structural basis for dynamic regulation of the human 26S proteasome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5T0I
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STRUCTURAL BASIS FOR DYNAMIC REGULATION OF THE HUMAN 26S PROTEASOME
Descriptor:26S protease regulatory subunit 7, 26S protease regulatory subunit 4, 26S protease regulatory subunit 8, ...
Authors:Chen, S., Wu, J., Lu, Y., Ma, Y.B., Lee, B.H., Yu, Z., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2016-08-16
Release date:2016-10-19
Last modified:2016-11-30
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Structural basis for dynamic regulation of the human 26S proteasome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5T0J
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STRUCTURAL BASIS FOR DYNAMIC REGULATION OF THE HUMAN 26S PROTEASOME
Descriptor:26S proteasome non-ATPase regulatory subunit 2, Proteasome subunit alpha type-6, Proteasome subunit alpha type-2, ...
Authors:Chen, S., Wu, J., Lu, Y., Ma, Y.B., Lee, B.H., Yu, Z., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2016-08-16
Release date:2016-10-19
Last modified:2016-11-30
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Structural basis for dynamic regulation of the human 26S proteasome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5VGZ
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-12
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHF
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHH
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHI
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHJ
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHM
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-09-12
Method:ELECTRON MICROSCOPY (8.3 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHN
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHO
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (8.3 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHP
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHQ
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (8.9 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHR
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHS
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (8.8 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
1DUJ
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SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2
Descriptor:SPINDLE ASSEMBLY CHECKPOINT PROTEIN
Authors:Luo, X., Fang, G., Coldiron, M., Lin, Y., Yu, H.
Deposit date:2000-01-17
Release date:2000-03-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.
Nat.Struct.Biol., 7, 2000
5JG6
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APC11-UBV SHOWS ROLE OF NONCOVALENT RING-UBIQUITIN INTERACTIONS IN PROCESSIVE MULTIUBIQUITINATION AND UBIQUITIN CHAIN ELONGATION BY APC/C
Descriptor:Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION
Authors:Brown, N.G., Zhang, W., Yu, S., Miller, D.J., Sidhu, S.S., Schulman, B.A.
Deposit date:2016-04-19
Release date:2016-06-15
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.0013 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5L9T
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C-CDH1) WITH E2 UBE2S POISED FOR POLYUBIQUITINATION WHERE UBE2S, APC2, AND APC11 ARE MODELED INTO LOW RESOLUTION DENSITY
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Brown, N.G., VanderLinden, R., Dube, P., Haselbach, D., Peters, J.M., Stark, H., Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-10-26
Last modified:2016-11-02
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5L9U
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C-CDH1) WITH A CROSS LINKED UBIQUITIN VARIANT-SUBSTRATE-UBE2C (UBCH10) COMPLEX REPRESENTING KEY FEATURES OF MULTIUBIQUITINATION
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Brown, N.G., VanderLinden, R., Dube, P., Haselbach, D., Peters, J.M., Stark, H., Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-09-14
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
1S2H
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THE MAD2 SPINDLE CHECKPOINT PROTEIN POSSESSES TWO DISTINCT NATIVELY FOLDED STATES
Descriptor:Mitotic spindle assembly checkpoint protein MAD2A
Authors:Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo, J., Yu, H.
Deposit date:2004-01-08
Release date:2004-03-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Mad2 spindle checkpoint protein has two distinct natively folded states.
Nat.Struct.Mol.Biol., 11, 2004
2QYF
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CRYSTAL STRUCTURE OF THE MAD2/P31(COMET)/MAD2-BINDING PEPTIDE TERNARY COMPLEX
Descriptor:Mitotic spindle assembly checkpoint protein MAD2A, MAD2L1-binding protein, peptide
Authors:Tomchick, D.R., Luo, X.
Deposit date:2007-08-14
Release date:2008-01-29
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:p31comet blocks Mad2 activation through structural mimicry.
Cell(Cambridge,Mass.), 131, 2007