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1KJY
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CRYSTAL STRUCTURE OF HUMAN G[ALPHA]I1 BOUND TO THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT, REGULATOR OF G-PROTEIN SIGNALING 14, ...
Authors:Kimple, R.J., Kimple, M.E., Betts, L., Sondek, J., Siderovski, D.P.
Deposit date:2001-12-05
Release date:2002-05-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature, 416, 2002
2OM2
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CRYSTAL STRUCTURE OF HUMAN G[ALPHA]I1 BOUND TO THE GOLOCO MOTIF OF RGS14
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, Regulator of G-protein signalling 14 GoLoco motif peptide, ...
Authors:Siderovski, D.P., Kimple, R.J.
Deposit date:2007-01-20
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities.
J.Mol.Biol., 371, 2007
3ONW
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STRUCTURE OF A G-ALPHA-I1 MUTANT WITH ENHANCED AFFINITY FOR THE RGS14 GOLOCO MOTIF.
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Kimple, A.J., Sammond, D.W., Miley, M.J., Machius, M., Kuhlman, B., Willard, F.S., Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
3QI2
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A GALPHA P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE: G42R BOUND TO RGS14 GOLOCO
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-26
Release date:2012-02-01
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
2XNS
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CRYSTAL STRUCTURE OF HUMAN G ALPHA I1 BOUND TO A DESIGNED HELICAL PEPTIDE DERIVED FROM THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, REGULATOR OF G-PROTEIN SIGNALING 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Sammond, D.W., Butterfoss, G.L., Machius, M., Siderovski, D.P., Kuhlman, B.
Deposit date:2010-08-05
Release date:2011-06-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Computational Design of the Sequence and Structure of a Protein-Binding Peptide.
J.Am.Chem.Soc., 133, 2011