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3TK5
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FACTOR XA IN COMPLEX WITH D102-4380
Descriptor:Factor X heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
3TK6
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FACTOR XA IN COMPLEX WITH D46-5241
Descriptor:Factor X heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
3Q3K
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FACTOR XA IN COMPLEX WITH A PHENYLENEDIAMINE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Imai, E.
Deposit date:2010-12-22
Release date:2011-12-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
2EI6
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FACTOR XA IN COMPLEX WITH THE INHIBITOR (-)-CIS-N1-[(5-CHLOROINDOL-2-YL)CARBONYL]-N2-[(5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDIN-2-YL)CARBONYL]-1,2-CYCLOHEXANEDIAMINE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2007-03-12
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2EI7
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FACTOR XA IN COMPLEX WITH THE INHIBITOR TRANS-N1-[(5-CHLOROINDOL-2-YL)CARBONYL]-N2-[(5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDIN-2-YL)CARBONYL]-1,2-CYCLOHEXANEDIAMINE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2007-03-12
Release date:2008-03-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors
To be Published
2EI8
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FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-CHLOROINDOL-2-YL)CARBONYL]-4-(N,N-DIMETHYLCARBAMOYL)-N2-[(5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDIN-2-YL)CARBONYL]-1,2-CYCLOHEXANEDIAMINE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2007-03-12
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A Novel, Potent and Orally Active Direct Inhibitor of Factor Xa
To be Published
3IIT
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FACTOR XA IN COMPLEX WITH A CIS-1,2-DIAMINOCYCLOHEXANE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M.
Deposit date:2009-08-03
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg.Med.Chem., 17, 2009