Author results

5AQF
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ADENOSINE, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQG
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, (2R,3R,4S,5R)-2-(3-AMINO-5-METHYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-1(5H)-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQH
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, 5-methyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQI
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, DIMETHYL SULFOXIDE, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQJ
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, CHLORIDE ION, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQK
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQL
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQM
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQN
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, BENZOFURO[3,2-D]PYRIMIDIN-4(3H)-ONE, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQO
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, GLYCEROL, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQP
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, quinazolin-4-amine, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQQ
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, 7-methylquinazolin-4-amine, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQR
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQS
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ISOQUINOLIN-1-AMINE, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQT
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, (1S,2R,3R,5R)-3-(hydroxymethyl)-5-(quinazolin-4-ylamino)cyclopentane-1,2-diol, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQU
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, GLYCEROL, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQV
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQW
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK 70 KDA PROTEIN 1A, (1S,2R,3R,5R)-3-(hydroxymethyl)-5-(quinazolin-4-ylamino)cyclopentane-1,2-diol, PHOSPHATE ION, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQX
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK 70 KDA PROTEIN 1A, (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol, DIMETHYL SULFOXIDE, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQY
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK 70 KDA PROTEIN 1A, ADENOSINE, 1,2-ETHANEDIOL, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQZ
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HSP72 WITH ADENOSINE-DERIVED INHIBITOR
Descriptor:HEAT SHOCK 70 KDA PROTEIN 1A, SANGIVAMYCIN, 1,2-ETHANEDIOL
Authors:Cheeseman, M.D., Westwood, I.M., Barbeau, O., Rowlands, M.G., Jones, A.M., Jeganathan, F., Burke, R., Dobson, S.E., Workman, P., Collins, I., van Montfort, R.L.M., Jones, K.
Deposit date:2015-09-22
Release date:2016-05-11
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of Hsp70.
J.Med.Chem., 59, 2016
5AR0
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HSP72 WITH ADENOSINE-DERIVED INHIBITOR
Descriptor:HEAT SHOCK 70 KDA PROTEIN 1A, (2R,3R,4S,5R)-2-(6-amino-8-((quinolin-7-ylmethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, GLYCEROL, ...
Authors:Cheeseman, M.D., Westwood, I.M., Barbeau, O., Rowlands, M.G., Jones, A.M., Jeganathan, F., Burke, R., Dobson, S.E., Workman, P., Collins, I., van Montfort, R.L.M., Jones, K.
Deposit date:2015-09-22
Release date:2016-05-11
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of Hsp70.
J.Med.Chem., 59, 2016
2UWD
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INHIBITION OF THE HSP90 MOLECULAR CHAPERONE IN VITRO AND IN VIVO BY NOVEL, SYNTHETIC, POTENT RESORCINYLIC PYRAZOLE, ISOXAZOLE AMIDE ANALOGS
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, SULFATE ION, ...
Authors:Sharp, S.Y., Prodromou, C., Boxall, K., Powers, M.V., Holmes, J.L., Box, G., Matthews, T.P., Cheung, K.M., Kalusa, A., James, K., Hayes, A., Hardcastle, A., Dymock, B., Brough, P.A., Barril, X., Cansfield, J.E., Wright, L.M., Surgenor, A., Foloppe, N., Aherne, W., Pearl, L., Jones, K., McDonald, E., Raynaud, F., Eccles, S., Drysdale, M., Workman, P.
Deposit date:2007-03-20
Release date:2007-04-24
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol. Cancer Ther., 6, 2007
4BDA
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FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2)
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, NITRATE ION, 1,2-ETHANEDIOL, ...
Authors:Silva-Santisteban, M.C., Westwood, I.M., Boxall, K., Brown, N., Peacock, S., McAndrew, C., Barrie, E., Richards, M., Mirza, A., Oliver, A.W., Burke, R., Hoelder, S., Jones, K., Aherne, G.W., Blagg, J., Collins, I., Garrett, M.D., van Montfort, R.L.M.
Deposit date:2012-10-05
Release date:2013-06-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2.
Plos One, 8, 2013
4BDB
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FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2)
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, NITRATE ION, 1,2-ETHANEDIOL, ...
Authors:Silva-Santisteban, M.C., Westwood, I.M., Boxall, K., Brown, N., Peacock, S., McAndrew, C., Barrie, E., Richards, M., Mirza, A., Oliver, A.W., Burke, R., Hoelder, S., Jones, K., Aherne, G.W., Blagg, J., Collins, I., Garrett, M.D., van Montfort, R.L.M.
Deposit date:2012-10-05
Release date:2013-06-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2.
Plos One, 8, 2013
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