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5AR0

HSP72 with adenosine-derived inhibitor

Summary for 5AR0
Entry DOI10.2210/pdb5ar0/pdb
Related5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 5AQW 5AQX 5AQY 5AQZ
DescriptorHEAT SHOCK 70 KDA PROTEIN 1A, (2R,3R,4S,5R)-2-(6-amino-8-((quinolin-7-ylmethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, GLYCEROL, ... (6 entities in total)
Functional Keywordsheat shock protein, hsp70, hsp72, atpase, chaperone, adenosine, inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm : P0DMV8
Total number of polymer chains1
Total formula weight44087.33
Authors
Cheeseman, M.D.,Westwood, I.M.,Barbeau, O.,Rowlands, M.G.,Jones, A.M.,Jeganathan, F.,Burke, R.,Dobson, S.E.,Workman, P.,Collins, I.,van Montfort, R.L.M.,Jones, K. (deposition date: 2015-09-22, release date: 2016-05-11, Last modification date: 2024-01-10)
Primary citationCheeseman, M.D.,Westwood, I.M.,Barbeau, O.,Rowlands, M.G.,Dobson, S.,Jones, A.M.,Jeganathan, F.,Burke, R.,Kadi, N.,Workman, P.,Collins, I.,Van Montfort, R.L.M.,Jones, K.
Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of Hsp70.
J.Med.Chem., 59:4625-, 2016
Cited by
PubMed: 27119979
DOI: 10.1021/ACS.JMEDCHEM.5B02001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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