Author results

2J0N
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A PROTEOLYTICALLY TRUNCATED FORM OF SHIGELLA FLEXNERI IPAD
Descriptor:INVASIN IPAD
Authors:Johnson, S., Roversi, P., Lea, S.M.
Deposit date:2006-08-03
Release date:2006-11-02
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.
J. Biol. Chem., 282, 2007
2J0O
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SHIGELLA FLEXNERI IPAD
Descriptor:INVASIN IPAD, GLYCEROL
Authors:Johnson, S., Roversi, P., Lea, S.M.
Deposit date:2006-08-04
Release date:2006-11-02
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.
J. Biol. Chem., 282, 2007
2J9T
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BIPD OF BURKHOLDERIA PSEUDOMALLEI
Descriptor:MEMBRANE ANTIGEN, BORIC ACID, CITRATE ANION
Authors:Johnson, S., Roversi, P., Field, T., Deane, J.E., Galyov, E., Lea, S.M.
Deposit date:2006-11-16
Release date:2006-11-20
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Self-Chaperoning of the Type III Secretion System Needle Tip Proteins Ipad and Bipd.
J.Biol.Chem., 282, 2007
6R69
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IMPROVED MAP OF THE FLIPQR COMPLEX THAT FORMS THE CORE OF THE SALMONELLA TYPE III SECRETION SYSTEM EXPORT APPARATUS.
Descriptor:Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliR, Flagellar biosynthetic protein FliQ
Authors:Johnson, S., Kuhlen, L., Abrusci, P., Lea, S.M.
Deposit date:2019-03-26
Release date:2019-05-29
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:The structure of an injectisome export gate demonstrates conservation of architecture in the core complexes between flagellar and virulence type III secretion systems
To Be Published
6R6B
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STRUCTURE OF THE CORE SHIGELLA FLEXNERI TYPE III SECRETION SYSTEM EXPORT GATE COMPLEX SCTRST (SPA24/SPA9/SPA29).
Descriptor:Surface presentation of antigens protein SpaP, Surface presentation of antigens protein SpaR, Surface presentation of antigens protein SpaQ
Authors:Johnson, S., Kuhlen, L., Deme, J.C., Abrusci, P., Lea, S.M.
Deposit date:2019-03-26
Release date:2019-05-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The structure of an injectisome export gate demonstrates conservation of architecture in the core complexes between flagellar and virulence type III secretion systems
To Be Published
2JAA
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SEMET SUBSTITUTED SHIGELLA FLEXNERI IPAD
Descriptor:INVASIN IPAD
Authors:Johnson, S., Roversi, P., Espina, M., Olive, A., Deane, J.E., Birket, S., Field, T., Picking, W.D., Blocker, A.J., Galyov, E.E., Picking, W.L., Lea, S.M.
Deposit date:2006-11-24
Release date:2006-11-30
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Self-Chaperoning of the Type III Secretion System Needle Tip Proteins Ipad and Bipd.
J.Biol.Chem., 282, 2007
4AYD
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STRUCTURE OF A COMPLEX BETWEEN CCPS 6 AND 7 OF HUMAN COMPLEMENT FACTOR H AND NEISSERIA MENINGITIDIS FHBP VARIANT 1 R106A MUTANT
Descriptor:COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN, 1,2-ETHANEDIOL
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-20
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules
Plos Pathog., 8, 2012
4AYE
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STRUCTURE OF A COMPLEX BETWEEN CCPS 6 AND 7 OF HUMAN COMPLEMENT FACTOR H AND NEISSERIA MENINGITIDIS FHBP VARIANT 1 E283AE304A MUTANT
Descriptor:COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN, 1,2-ETHANEDIOL
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-20
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
4AYI
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STRUCTURE OF A COMPLEX BETWEEN CCPS 6 AND 7 OF HUMAN COMPLEMENT FACTOR H AND NEISSERIA MENINGITIDIS FHBP VARIANT 3 WILD TYPE
Descriptor:COMPLEMENT FACTOR H, LIPOPROTEIN GNA1870 CCOMPND 7, 1,2-ETHANEDIOL
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-21
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
4AYM
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STRUCTURE OF A COMPLEX BETWEEN CCPS 6 AND 7 OF HUMAN COMPLEMENT FACTOR H AND NEISSERIA MENINGITIDIS FHBP VARIANT 3 P106A MUTANT
Descriptor:COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-21
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
4AYN
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STRUCTURE OF THE C-TERMINAL BARREL OF NEISSERIA MENINGITIDIS FHBP VARIANT 2
Descriptor:FACTOR H-BINDING PROTEIN, SULFATE ION
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-21
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
4BIK
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STRUCTURE OF A DISULFIDE LOCKED MUTANT OF INTERMEDILYSIN WITH HUMAN CD59
Descriptor:INTERMEDILYSIN, CD59 GLYCOPROTEIN
Authors:Johnson, S., Brooks, N.J., Smith, R.A.G., Lea, S.M., Bubeck, D.
Deposit date:2013-04-10
Release date:2013-05-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (3.494 Å)
Cite:Structural Basis for Recognition of the Pore- Forming Toxin Intermedilysin by Human Complement Receptor Cd59
Cell Rep., 3, 2013
2IXR
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BIPD OF BURKHOLDERIA PSEUDOMALLEI
Descriptor:MEMBRANE ANTIGEN
Authors:Roversi, P., Johnson, S., Field, T., Deane, J.E., Galyov, E.E., Lea, S.M.
Deposit date:2006-07-10
Release date:2006-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Self-Chaperoning of the Type III Secretion System Needle Tip Proteins Ipad and Bipd.
J.Biol.Chem., 282, 2007
2VJ2
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HUMAN JAGGED-1, DOMAINS DSL AND EGFS1-3
Descriptor:JAGGED-1, D-MALATE
Authors:Johnson, S., Cordle, J., Tay, J.Z., Roversi, P., Handford, P.A., Lea, S.M.
Deposit date:2007-12-06
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.
Nat.Struct.Mol.Biol., 15, 2008
2VJ3
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HUMAN NOTCH-1 EGFS 11-13
Descriptor:NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION, SODIUM ION, ...
Authors:Johnson, S., Cordle, J., Tay, J.Z., Roversi, P., Lea, S.M.
Deposit date:2007-12-06
Release date:2008-07-29
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.
Nat.Struct.Mol.Biol., 15, 2008
5NQP
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STRUCTURE OF A FHBP(V1.4):PORA(P1.16) CHIMERA. FUSION AT FHBP POSITION 151.
Descriptor:Factor H binding protein variant B16_001,Major outer membrane protein P.IA,Factor H binding protein variant B16_001, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Johnson, S., Hollingshead, S., Lea, S.M., Tang, C.M.
Deposit date:2017-04-20
Release date:2018-02-28
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
5NQX
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STRUCTURE OF A FHBP(V1.1):PORA(P1.16) CHIMERA. FUSION AT FHBP POSITION 294.
Descriptor:Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein
Authors:Johnson, S., Jongerius, I., Lea, S.M., Tang, C.M.
Deposit date:2017-04-21
Release date:2018-02-28
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (3.66 Å)
Cite:Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
5NQY
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STRUCTURE OF A FHBP(V1.4):PORA(P1.16) CHIMERA. FUSION AT FHBP POSITION 309.
Descriptor:Factor H binding protein variant B16_001,Major outer membrane protein P.IA,Factor H binding protein variant B16_001
Authors:Johnson, S., Hollingshead, S., Lea, S.M., Tang, C.M.
Deposit date:2017-04-21
Release date:2018-02-28
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
5NQZ
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STRUCTURE OF A FHBP(V1.1):PORA(P1.16) CHIMERA. FUSION AT FHBP POSITION 309.
Descriptor:Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein, ZINC ION, ACETATE ION, ...
Authors:Johnson, S., Hollingshead, S., Lea, S.M., Tang, C.M.
Deposit date:2017-04-21
Release date:2018-02-28
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
6F2D
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A FLIPQR COMPLEX FORMS THE CORE OF THE SALMONELLA TYPE III SECRETION SYSTEM EXPORT APPARATUS.
Descriptor:Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliR, Flagellar biosynthetic protein FliQ
Authors:Johnson, S., Kuhlen, L., Abrusci, P., Lea, S.M.
Deposit date:2017-11-24
Release date:2018-07-04
Last modified:2018-07-25
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the core of the type III secretion system export apparatus.
Nat. Struct. Mol. Biol., 25, 2018
4BY2
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SAS-4 (DCPAP) TCP DOMAIN IN COMPLEX WITH A PROLINE RICH MOTIF OF ANA2 (DSTIL) OF DROSOPHILA MELANOGASTER
Descriptor:ANASTRAL SPINDLE 2, SAS 4, 1,2-ETHANEDIOL
Authors:Cottee, M.A., Muschalik, N., Wong, Y.L., Johnson, C.M., Johnson, S., Andreeva, A., Oegema, K., Lea, S.M., Raff, J.W., van Breugel, M.
Deposit date:2013-07-17
Release date:2013-09-18
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly.
Elife, 2, 2013
2CA5
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MXIH NEEDLE PROTEIN OF SHIGELLA FLEXNERI (MONOMERIC FORM, RESIDUES 1- 78)
Descriptor:MXIH, ISOPROPYL ALCOHOL, GLYCEROL, ...
Authors:Deane, J.E., Roversi, P., Cordes, F.S., Johnson, S., Kenjale, R., Picking, W.L., Picking, W.D., Blocker, A.J., Lea, S.M.
Deposit date:2005-12-16
Release date:2006-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular Model of a Type III Secretion System Needle: Implications for Host-Cell Sensing
Proc.Natl.Acad.Sci.USA, 103, 2006
4A5P
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STRUCTURE OF THE SHIGELLA FLEXNERI MXIA PROTEIN
Descriptor:PROTEIN MXIA, 1,2-ETHANEDIOL
Authors:Abrusci, P., Vegara-Irigaray, M., Johnson, S., Roversi, P., Friede, M.E., Deane, J.E., Tang, C.M., Lea, S.M.
Deposit date:2011-10-26
Release date:2012-11-14
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Architecture of the major component of the type III secretion system export apparatus.
Nat.Struct.Mol.Biol., 20, 2013
2V6L
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MOLECULAR MODEL OF A TYPE III SECRETION SYSTEM NEEDLE
Descriptor:MXIH
Authors:Deane, J.E., Roversi, P., Cordes, F.S., Johnson, S., Kenjale, R., Daniell, S., Booy, F., Picking, W.L., Picking, W.D., Blocker, A.J., Lea, S.M.
Deposit date:2007-07-19
Release date:2007-07-31
Last modified:2018-03-28
Method:ELECTRON MICROSCOPY (16 Å)
Cite:Molecular model of a type III secretion system needle: Implications for host-cell sensing.
Proc. Natl. Acad. Sci. U.S.A., 103, 2006
2W80
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STRUCTURE OF A COMPLEX BETWEEN NEISSERIA MENINGITIDIS FACTOR H BINDING PROTEIN AND CCPS 6-7 OF HUMAN COMPLEMENT FACTOR H
Descriptor:COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
Authors:Schneider, M.C., Prosser, B.E., Caesar, J.J.E., Kugelberg, E., Li, S., Zhang, Q., Quoraishi, S., Lovett, J.E., Deane, J.E., Sim, R.B., Roversi, P., Johnson, S., Tang, C.M., Lea, S.M.
Deposit date:2009-01-08
Release date:2009-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.
Nature, 458, 2009