Author results

1F1B
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CRYSTAL STRUCTURE OF E. COLI ASPARTATE TRANSCARBAMOYLASE P268A MUTANT IN THE R-STATE IN THE PRESENCE OF N-PHOSPHONACETYL-L-ASPARTATE
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
Authors:Jin, L., Stec, B., Kantrowitz, E.R.
Deposit date:2000-05-18
Release date:2000-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A cis-proline to alanine mutant of E. coli aspartate transcarbamoylase: kinetic studies and three-dimensional crystal structures.
Biochemistry, 39, 2000
1PZU
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AN ASYMMETRIC NFAT1-RHR HOMODIMER ON A PSEUDO-PALINDROMIC, KAPPA-B SITE
Descriptor:5'-D(*TP*TP*GP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*A)-3', 5'-D(*AP*AP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*TP*C)-3', Nuclear factor of activated T-cells, ...
Authors:Jin, L., Sliz, P., Chen, L., Macian, F., Rao, A., Hogan, P.G., Harrison, S.C.
Deposit date:2003-07-14
Release date:2003-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:An asymmetric NFAT1 dimer on a pseudo-palindromic KB-like DNA site
Nat.Struct.Biol., 10, 2003
1AZX
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ANTITHROMBIN/PENTASACCHARIDE COMPLEX
Descriptor:ANTITHROMBIN, N-ACETYL-D-GLUCOSAMINE, HEPARIN PENTASACCHARIDE
Authors:Jin, L., Abrahams, J.P., Skinner, R., Petitou, M., Pike, R.N., Carrell, R.W.
Deposit date:1997-11-23
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The anticoagulant activation of antithrombin by heparin.
Proc.Natl.Acad.Sci.USA, 94, 1997
1D09
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ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH N-PHOSPHONACETYL-L-ASPARTATE (PALA)
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
Authors:Jin, L., Stec, B., Lipscomb, W.N., Kantrowitz, E.R.
Deposit date:1999-09-09
Release date:2000-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1 A.
Proteins, 37, 1999
1ET1
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CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION
Descriptor:PARATHYROID HORMONE, SODIUM ION
Authors:Jin, L., Briggs, S.L., Chandrasekhar, S., Chirgadze, N.Y., Clawson, D.K., Schevitz, R.W., Smiley, D.L., Tashjian, A.H., Zhang, F.
Deposit date:2000-04-12
Release date:2000-09-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.
J.Biol.Chem., 275, 2000
1EZZ
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CRYSTAL STRUCTURE OF E. COLI ASPARTATE TRANSCARBAMOYLASE P268A MUTANT IN THE T-STATE
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ZINC ION
Authors:Jin, L., Stec, B., Kantrowitz, E.R.
Deposit date:2000-05-12
Release date:2000-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A cis-proline to alanine mutant of E. coli aspartate transcarbamoylase: kinetic studies and three-dimensional crystal structures.
Biochemistry, 39, 2000
1MF8
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CRYSTAL STRUCTURE OF HUMAN CALCINEURIN COMPLEXED WITH CYCLOSPORIN A AND HUMAN CYCLOPHILIN
Descriptor:CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ALPHA ISOFORM, CALCINEURIN B SUBUNIT ISOFORM 1, ...
Authors:Jin, L., Harrison, S.C.
Deposit date:2002-08-09
Release date:2002-10-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of Human Calcineurin Complexed with Cyclosporin a and Human Cyclophilin
Proc.Natl.Acad.Sci.USA, 99, 2002
1U59
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CRYSTAL STRUCTURE OF THE ZAP-70 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE
Descriptor:Tyrosine-protein kinase ZAP-70, STAUROSPORINE
Authors:Jin, L., Pluskey, S., Petrella, E.C., Cantin, S.M., Gorga, J.C., Rynkiewicz, M.J., Pandey, P., Strickler, J.E., Babine, R.E., Weaver, D.T., Seidl, K.J.
Deposit date:2004-07-27
Release date:2004-08-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS
J.Biol.Chem., 279, 2004
1XX9
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CRYSTAL STRUCTURE OF THE FXIA CATALYTIC DOMAIN IN COMPLEX WITH ECOTINM84R
Descriptor:Coagulation factor XI, Ecotin, N-ACETYL-D-GLUCOSAMINE
Authors:Jin, L., Pandey, P., Babine, R.E., Gorga, J.C., Seidl, K.J., Gelfand, E., Weaver, D.T., Abdel-Meguid, S.S., Strickler, J.E.
Deposit date:2004-11-04
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions
J.Biol.Chem., 280, 2005
1XXD
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CRYSTAL STRUCTURE OF THE FXIA CATALYTIC DOMAIN IN COMPLEX WITH MUTATED ECOTIN
Descriptor:Coagulation factor XI, Ecotin
Authors:Jin, L., Pandey, P., Babine, R.E., Gorga, J.C., Seidl, K.J., Gelfand, E., Weaver, D.T., Abdel-Meguid, S.S., Strickler, J.E.
Deposit date:2004-11-04
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions
J.Biol.Chem., 280, 2005
1XXF
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CRYSTAL STRUCTURE OF THE FXIA CATALYTIC DOMAIN IN COMPLEX WITH ECOTIN MUTANT (ECOTINP)
Descriptor:Coagulation factor XI, Ecotin, SODIUM ION
Authors:Jin, L., Pandey, P., Babine, R.E., Gorga, J.C., Seidl, K.J., Gelfand, E., Weaver, D.T., Abdel-Meguid, S.S., Strickler, J.E.
Deposit date:2004-11-04
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions
J.Biol.Chem., 280, 2005
1ZHM
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE COAGULATION FACTOR XIA IN COMPLEX WITH BENZAMIDINE (S434A-T475A-K437 MUTANT)
Descriptor:coagulation factor XI, BENZAMIDINE, GLUTATHIONE
Authors:Jin, L., Pandey, P., Babine, R.E., Weaver, D.T., Abdel-Meguid, S.S., Strickler, J.E.
Deposit date:2005-04-26
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors.
Acta Crystallogr.,Sect.D, 61, 2005
1ZHP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH BENZAMIDINE (S434A-T475A-K505 MUTANT)
Descriptor:coagulation factor XI, BENZAMIDINE, GLUTATHIONE
Authors:Jin, L., Pandey, P., Babine, R.E., Weaver, D.T., Abdel-Meguid, S.S., Strickler, J.E.
Deposit date:2005-04-26
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors.
Acta Crystallogr.,Sect.D, 61, 2005
1ZHR
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH BENZAMIDINE (S434A-T475A-C482S-K437A MUTANT)
Descriptor:coagulation factor XI, BENZAMIDINE
Authors:Jin, L., Pandey, P., Babine, R.E., Weaver, D.T., Abdel-Meguid, S.S., Strickler, J.E.
Deposit date:2005-04-26
Release date:2005-09-20
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors.
Acta Crystallogr.,Sect.D, 61, 2005
3CMO
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HIV NEUTRALIZING MONOCLONAL ANTIBODY YZ18
Descriptor:Fab light chain, Fab heavy chain
Authors:Jin, L., Prasad, V., Paul, S.
Deposit date:2008-03-24
Release date:2008-08-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:HIV neutralizing monoclonal antibody YZ18
TO BE PUBLISHED
3GLR
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ACETYL-LYSINE ACECS2 PEPTIDE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLS
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CRYSTAL STRUCTURE OF HUMAN SIRT3
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, ZINC ION, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLT
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ADPR BOUND TO THE ACECS2 PEPTIDE CONTAINING A THIOACETYL LYSINE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLU
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ACECS2 PEPTIDE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
1ZJD
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH KUNITZ PROTEASE INHIBITOR DOMAIN OF PROTEASE NEXIN II
Descriptor:Catalytic Domain of Coagulation Factor XI, Kunitz Protease Inhibitory Domain of Protease Nexin II
Authors:Jin, L., Navaneetham, D., Pandey, P., Strickler, J.E., Babine, R.E., Walsh, P.N., Abdel-Meguid, S.S.
Deposit date:2005-04-28
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Mutational Analyses of the Molecular Interactions between the Catalytic Domain of Factor XIa and the Kunitz Protease Inhibitor Domain of Protease Nexin 2
J.Biol.Chem., 280, 2005
2FDA
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COAGULATION FACTOR XIA IN COMPLEX WITH ALPHA-KETOTHIAZOLE ARGININE DERIVED LIGAND
Descriptor:Coagulation factor XI, BICARBONATE ION, SULFATE ION, ...
Authors:Jin, L., Pandey, P., Babine, R.E., Weaver, D.T., Abdel-Meguid, S.S., Strickler, J.E.
Deposit date:2005-12-13
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine
Bioorg.Med.Chem.Lett., 16, 2006
1AKM
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ORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLI
Descriptor:ORNITHINE TRANSCARBAMYLASE
Authors:Head, J.F., Seaton, B., Jin, L.
Deposit date:1997-05-23
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure at 2.8 A resolution of anabolic ornithine transcarbamylase from Escherichia coli.
Nat.Struct.Biol., 4, 1997
3CLE
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HIV NEUTRALIZING MONOCLONAL ANTIBODY YZ23
Descriptor:Fab light chain, Fab heavy chain
Authors:Jin, L., Paul, S., Symersky, J.
Deposit date:2008-03-18
Release date:2008-03-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:HIV neutralizing monoclonal antibody YZ23
To be Published
3QOW
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DOT1L STRUCTURE IN COMPLEX WITH SAM
Descriptor:Histone-lysine N-methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION
Authors:Jin, L.
Deposit date:2011-02-11
Release date:2011-05-25
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Chemogenetic analysis of human protein methyltransferases.
Chem.Biol.Drug Des., 78, 2011
3QOX
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DOT1L STRUCTURE IN COMPLEX WITH SAH
Descriptor:Histone-lysine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
Authors:Jin, L.
Deposit date:2011-02-11
Release date:2011-05-25
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chemogenetic analysis of human protein methyltransferases.
Chem.Biol.Drug Des., 78, 2011