1CD9
 
 | | 2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (G-CSF RECEPTOR), PROTEIN (GRANULOCYTE COLONY-STIMULATING FACTOR) | | Authors: | Aritomi, M, Kunishima, N, Okamoto, T, Kuroki, R, Ota, Y, Morikawa, K. | | Deposit date: | 1999-03-08 | | Release date: | 2000-03-08 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme.
Nature, 401, 1999
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1AF3
 | | RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN | | Descriptor: | APOPTOSIS REGULATOR BCL-X | | Authors: | Aritomi, M, Kunishima, N, Inohara, N, Ishibashi, Y, Ohta, S, Morikawa, K. | | Deposit date: | 1997-03-21 | | Release date: | 1997-07-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family.
J.Biol.Chem., 272, 1997
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2JNJ
 | | Solution structure of the p8 TFIIH subunit | | Descriptor: | TFIIH basal transcription factor complex TTD-A subunit | | Authors: | Vitorino, M, Atkinson, R.A, Moras, D, Poterszman, A, Kieffer, B, Structural Proteomics in Europe 2 (SPINE-2) | | Deposit date: | 2007-01-26 | | Release date: | 2007-04-10 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Solution Structure and Self-association Properties of the p8 TFIIH Subunit Responsible for Trichothiodystrophy
J.Mol.Biol., 368, 2007
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1IT3
 | | Hagfish CO ligand hemoglobin | | Descriptor: | CARBON MONOXIDE, PROTOPORPHYRIN IX CONTAINING FE, hemoglobin | | Authors: | Mito, M, Chong, K.T, Park, S.-Y, Tame, J.R. | | Deposit date: | 2002-01-05 | | Release date: | 2002-01-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of deoxy- and carbonmonoxyhemoglobin F1 from the hagfish Eptatretus burgeri
J.Biol.Chem., 277, 2002
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1IT2
 | | Hagfish deoxy hemoglobin | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, hemoglobin | | Authors: | Mito, M, Chong, K.T, Park, S.-Y, Tame, J.R. | | Deposit date: | 2002-01-05 | | Release date: | 2002-01-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structures of deoxy- and carbonmonoxyhemoglobin F1 from the hagfish Eptatretus burgeri
J.Biol.Chem., 277, 2002
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1PGR
 | | 2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR | | Descriptor: | PROTEIN (G-CSF RECEPTOR), PROTEIN (GRANULOCYTE COLONY-STIMULATING FACTOR) | | Authors: | Aritomi, M, Kunishima, N, Okamoto, T, Kuroki, R, Ota, Y, Morikawa, K. | | Deposit date: | 1999-03-08 | | Release date: | 2000-03-08 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme.
Nature, 401, 1999
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8GKH
 | | Structure of the Spizellomyces punctatus Fanzor (SpuFz) in complex with omega RNA and target DNA | | Descriptor: | DNA (35-MER), DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), MAGNESIUM ION, ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2023-03-19 | | Release date: | 2023-07-05 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Fanzor is a eukaryotic programmable RNA-guided endonuclease.
Nature, 620, 2023
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5MR6
 | | XiaF from Streptomyces sp. in complex with FADH2 and Glycerol | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, XiaF protein | | Authors: | Kugel, S, Baunach, M, Baer, P, Ishida-Ito, M, Sundaram, S, Xu, Z, Groll, M, Hertweck, C. | | Deposit date: | 2016-12-21 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.
Nat Commun, 8, 2017
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5LVU
 | | XiaF (apo) from Streptomyces sp. | | Descriptor: | SULFATE ION, XiaF protein | | Authors: | Kugel, S, Baunach, M, Baer, P, Ishida-Ito, M, Sundaram, S, Xu, Z, Groll, M, Hertweck, C. | | Deposit date: | 2016-09-14 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.
Nat Commun, 8, 2017
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5LVW
 | | XiaF (FADH2) from Streptomyces sp. | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, INDOLE, SULFATE ION, ... | | Authors: | Kugel, S, Baunach, M, Baer, P, Ishida-Ito, M, Sundaram, S, Xu, Z, Groll, M, Hertweck, C. | | Deposit date: | 2016-09-14 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.
Nat Commun, 8, 2017
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9CF0
 | | Parasitella parasitica Fanzor (PpFz) State 1 | | Descriptor: | DNA (5'-D(P*AP*CP*CP*CP*GP*GP*GP*AP*TP*AP*A)-3'), DNA (5'-D(P*TP*GP*TP*TP*TP*AP*TP*CP*CP*CP*GP*GP*GP*T)-3'), DNA/RNA (54-MER), ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CET
 | | Guillardia theta Fanzor (GtFz) State 3 | | Descriptor: | DNA (28-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*TP*AP*AP*AP*GP*GP*CP*CP*CP*CP*GP*GP*G)-3'), Maltose/maltodextrin-binding periplasmic protein, ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CER
 | | Guillardia theta Fanzor (GtFz) State 1 | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein, Guillardia theta Fanzor1 chimera, RNA (142-MER) | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CEZ
 | | Spizellomyces punctatus Fanzor (SpuFz) State 6 | | Descriptor: | DNA (27-MER), DNA (5'-D(P*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), MAGNESIUM ION, ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CEX
 | | Spizellomyces punctatus Fanzor (SpuFz) State 4 | | Descriptor: | DNA (29-MER), DNA (5'-D(*(MG)*(MG)P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CEY
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9CF3
 | | Parasitella parasitica Fanzor (PpFz) State 4 | | Descriptor: | DNA (31-MER), DNA (5'-D(P*AP*CP*CP*CP*GP*GP*GP*TP*AP*TP*A)-3'), DNA/RNA (56-MER), ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CEV
 | | Spizellomyces punctatus Fanzor (SpuFz) State 2 | | Descriptor: | DNA (35-MER), DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), MAGNESIUM ION, ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CEW
 | | Spizellomyces punctatus Fanzor (SpuFz) State 3 | | Descriptor: | DNA (29-MER), DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CEU
 | | Spizellomyces punctatus Fanzor (SpuFz) State 1 | | Descriptor: | DNA (5'-D(P*CP*CP*TP*AP*TP*AP*GP*AP*TP*AP*TP*GP*CP*CP*CP*GP*GP*GP*TP*AP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), Maltose/maltodextrin-binding periplasmic protein, ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CF1
 | | Parasitella parasitica Fanzor (PpFz) State 2 | | Descriptor: | DNA (5'-D(P*AP*CP*CP*CP*GP*GP*GP*AP*TP*AP*A)-3'), DNA (5'-D(P*GP*CP*TP*GP*GP*AP*TP*GP*TP*TP*TP*AP*TP*CP*CP*CP*GP*GP*GP*T)-3'), DNA/RNA (51-MER), ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CES
 | | Guillardia theta Fanzor (GtFz) State 2 | | Descriptor: | DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*TP*AP*AP*AP*GP*GP*CP*CP*CP*CP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*GP*GP*GP*GP*CP*CP*TP*TP*TP*AP*AP*G)-3'), Maltose/maltodextrin-binding periplasmic protein, ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CF2
 | | Parasitella parasitica Fanzor (PpFz) State 3 | | Descriptor: | DNA (26-MER), DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | | Authors: | Xu, P, Saito, M, Zhang, F. | | Deposit date: | 2024-06-27 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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7F1D
 | | Crystal Structure of BACE1 in complex with N-{3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-2H,3H-[1,4]dioxino[2,3-c]pyridine-7-carboxamide | | Descriptor: | Beta-secretase 1, IODIDE ION, N-[3-[(4R,5R,6R)-2-azanyl-5-fluoranyl-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluoranyl-phenyl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide | | Authors: | Ueno, T, Matsuoka, E, Asada, N, Yamamoto, S, Kanegawa, N, Ito, M, Ito, H, Moechars, D, Rombouts, F.J.R, Gijsen, H.J.M, Kusakabe, K.I. | | Deposit date: | 2021-06-09 | | Release date: | 2022-02-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Discovery of Extremely Selective Fused Pyridine-Derived beta-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.
J.Med.Chem., 64, 2021
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7F1G
 | | BACE2 xaperone complex with N-{3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-2H,3H-[1,4]dioxino[2,3-c]pyridine-7-carboxamide | | Descriptor: | Beta-secretase 2, N-[3-[(4R,5R,6R)-2-azanyl-5-fluoranyl-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluoranyl-phenyl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide, XAPERONE | | Authors: | Ueno, T, Matsuoka, E, Asada, N, Yamamoto, S, Kanegawa, N, Ito, M, Ito, H, Moechars, D, Rombouts, F.J.R, Gijsen, H.J.M, Kusakabe, K.I. | | Deposit date: | 2021-06-09 | | Release date: | 2022-02-23 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Discovery of Extremely Selective Fused Pyridine-Derived beta-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.
J.Med.Chem., 64, 2021
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