5JPQ
 
 | | Cryo-EM structure of the 90S pre-ribosome | | Descriptor: | 18S ribosomal RNA, Bms1, Emg1, ... | | Authors: | Turk, M, Cheng, J, Berninghausen, O, Kornprobst, M, Flemming, D, Kos-Braun, I.C, Kos, M, Thoms, M, Hurt, E, Beckmann, R. | | Deposit date: | 2016-05-04 | | Release date: | 2016-07-27 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (7.3 Å) | | Cite: | Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.
Cell, 166, 2016
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4V7F
 | | Arx1 pre-60S particle. | | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Leidig, C, Thoms, M, Holdermann, I, Bradatsch, B, Berninghausen, O, Bange, G, Sinning, I, Hurt, E, Beckmann, R. | | Deposit date: | 2013-12-10 | | Release date: | 2014-07-09 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (8.7 Å) | | Cite: | 60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
Nat Commun, 5, 2014
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8BGU
 | | human MDM2-5S RNP | | Descriptor: | 5S rRNA, 60S ribosomal protein L11, 60S ribosomal protein L5, ... | | Authors: | Castillo, N, Thoms, M, Flemming, D, Hammaren, H.M, Buschauer, R, Ameismeier, M, Bassler, J, Beck, M, Beckmann, R, Hurt, E. | | Deposit date: | 2022-10-28 | | Release date: | 2023-06-14 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2-p53 pathways.
Nat.Struct.Mol.Biol., 30, 2023
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9L5T
 | | Cryo-EM structure of the thermophile spliceosome (state B*Q2) | | Descriptor: | Anaphase-promoting complex subunit 4-like WD40 domain-containing protein, CCDC12, Delta(14)-sterol reductase, ... | | Authors: | Li, Y, Fischer, P, Wang, M, Yuan, R, Meng, W, Luehrmann, R, Lau, B, Hurt, E, Cheng, J. | | Deposit date: | 2024-12-23 | | Release date: | 2025-03-12 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.
Cell Res., 35, 2025
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9L5S
 | | Cryo-EM structure of the thermophile spliceosome (state B*Q1) | | Descriptor: | Anaphase-promoting complex subunit 4-like WD40 domain-containing protein, CCDC12, Delta(14)-sterol reductase, ... | | Authors: | Li, Y, Fischer, P, Wang, M, Yuan, R, Meng, W, Luehrmann, R, Lau, B, Hurt, E, Cheng, J. | | Deposit date: | 2024-12-23 | | Release date: | 2025-03-12 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.
Cell Res., 35, 2025
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9L5R
 | | Cryo-EM structure of the thermophile spliceosome (state ILS) | | Descriptor: | Anaphase-promoting complex subunit 4-like WD40 domain-containing protein, CCDC12, Cell cycle control protein, ... | | Authors: | Li, Y, Fischer, P, Wang, M, Yuan, R, Meng, W, Luehrmann, R, Lau, B, Hurt, E, Cheng, J. | | Deposit date: | 2024-12-23 | | Release date: | 2025-03-12 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.
Cell Res., 35, 2025
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6EML
 | | Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae | | Descriptor: | 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | | Authors: | Heuer, A, Thomson, E, Schmidt, C, Berninghausen, O, Becker, T, Hurt, E, Beckmann, R. | | Deposit date: | 2017-10-02 | | Release date: | 2017-11-29 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of a late pre-40S ribosomal subunit fromSaccharomyces cerevisiae.
Elife, 6, 2017
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1GO5
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5CWW
 | | Crystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159 TAIL-Nup145N APD complex | | Descriptor: | Nucleoporin NUP145N, Nucleoporin NUP159, Nucleoporin NUP82 | | Authors: | Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A. | | Deposit date: | 2015-07-28 | | Release date: | 2015-09-16 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
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5CWV
 | | Crystal structure of Chaetomium thermophilum Nup192 TAIL domain | | Descriptor: | Nucleoporin NUP192 | | Authors: | Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A. | | Deposit date: | 2015-07-28 | | Release date: | 2015-09-16 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.155 Å) | | Cite: | Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
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5CWU
 | | Crystal structure of Chaetomium thermophilum Nup188 TAIL domain | | Descriptor: | GLYCEROL, Nucleoporin NUP188 | | Authors: | Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A. | | Deposit date: | 2015-07-28 | | Release date: | 2015-09-16 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
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7OZS
 | | Structure of the hexameric 5S RNP from C. thermophilum | | Descriptor: | 5S rRNA, 60S ribosomal protein l5-like protein, Putative ribosomal protein, ... | | Authors: | Castillo, N, Thoms, M, Flemming, D, Hammaren, H.M, Buschauer, R, Ameismeier, M, Bassler, J, Beck, M, Beckmann, R, Hurt, E. | | Deposit date: | 2021-06-28 | | Release date: | 2022-10-12 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2-p53 pathways.
Nat.Struct.Mol.Biol., 2023
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6EM4
 | | State B architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 60S ribosomal protein L13-A, ... | | Authors: | Kater, L, Cheng, J, Barrio-Garcia, C, Hurt, E, Beckmann, R. | | Deposit date: | 2017-10-01 | | Release date: | 2017-12-27 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Cell, 171, 2017
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6EM5
 | | State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | | Descriptor: | 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 25S ribosomal RNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | | Authors: | Kater, L, Cheng, J, Barrio-Garcia, C, Hurt, E, Beckmann, R. | | Deposit date: | 2017-10-01 | | Release date: | 2017-12-27 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Cell, 171, 2017
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3M99
 | | Structure of the Ubp8-Sgf11-Sgf73-Sus1 SAGA DUB module | | Descriptor: | Protein SUS1, SAGA-associated factor 11, SAGA-associated factor 73, ... | | Authors: | Kohler, A, Zimmerman, E, Schneider, M, Hurt, E, Zheng, N. | | Deposit date: | 2010-03-21 | | Release date: | 2010-05-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.
Cell(Cambridge,Mass.), 141, 2010
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2MVF
 | | Structural insight into an essential assembly factor network on the pre-ribosome | | Descriptor: | Uncharacterized protein | | Authors: | Lee, W, Bassler, J, Paternoga, H, Holdermann, I, Thomas, M, Granneman, S, Barrio-Garcia, C, Nyarko, A, Stier, G, Clark, S.A, Schraivogel, D, Kallas, M, Beckmann, R, Tollervey, D, Barbar, E, Sinning, I, Hurt, E. | | Deposit date: | 2014-10-02 | | Release date: | 2014-12-03 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014
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2RFO
 | | Crystral Structure of the nucleoporin Nic96 | | Descriptor: | Nucleoporin NIC96 | | Authors: | Schrader, N, Stelter, P, Flemming, D, Kunze, K, Hurt, E, Vetter, I.R. | | Deposit date: | 2007-10-01 | | Release date: | 2008-01-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of the nic96 subcomplex organization in the nuclear pore channel.
Mol.Cell, 29, 2008
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4GYG
 | | Crystal structure of the Rio2 kinase from Chaetomium thermophilum | | Descriptor: | Rio2 kinase | | Authors: | Ferreira-Cerca, S, Sagar, V, Schafer, T, Diop, M, Wesseling, A.M, Lu, H, Chai, E, Hurt, E, LaRonde-LeBlanc, N. | | Deposit date: | 2012-09-05 | | Release date: | 2012-10-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.482 Å) | | Cite: | ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit.
Nat.Struct.Mol.Biol., 19, 2012
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3J2I
 | | Structure of late pre-60S ribosomal subunits with nuclear export factor Arx1 bound at the peptide exit tunnel | | Descriptor: | Eukaryotic translation initiation factor 6, Proliferation-associated protein 2G4 | | Authors: | Bradatsch, B, Leidig, C, Granneman, S, Gnaedig, M, Tollervey, D, Boettcher, B, Beckmann, R, Hurt, E. | | Deposit date: | 2012-10-04 | | Release date: | 2012-11-07 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (11.9 Å) | | Cite: | Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel.
Nat.Struct.Mol.Biol., 19, 2012
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5JCS
 | | CRYO-EM STRUCTURE OF THE RIX1-REA1 PRE-60S PARTICLE | | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Barrio-Garcia, C, Thoms, M, Flemming, D, Kater, L, Berninghausen, O, Bassler, J, Beckmann, R, Hurt, E. | | Deposit date: | 2016-04-15 | | Release date: | 2016-11-16 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling
Nat.Struct.Mol.Biol., 23, 2016
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6EM1
 | | State C (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 60S ribosomal protein L13-A, ... | | Authors: | Kater, L, Cheng, J, Barrio-Garcia, C, Hurt, E, Beckmann, R. | | Deposit date: | 2017-10-01 | | Release date: | 2017-12-27 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Cell, 171, 2017
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6ELZ
 | | State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | | Descriptor: | 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 25S ribosomal RNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | | Authors: | Kater, L, Cheng, J, Barrio-Garcia, C, Hurt, E, Beckmann, R. | | Deposit date: | 2017-09-30 | | Release date: | 2017-12-27 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Cell, 171, 2017
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6EM3
 | | State A architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 60S ribosomal protein L13-A, ... | | Authors: | Kater, L, Cheng, J, Barrio-Garcia, C, Hurt, E, Beckmann, R. | | Deposit date: | 2017-10-01 | | Release date: | 2017-12-27 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Cell, 171, 2017
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4WJU
 | | Crystal structure of Rsa4 from Saccharomyces cerevisiae | | Descriptor: | GLYCEROL, Ribosome assembly protein 4 | | Authors: | Holdermann, I, Bassler, J, Hurt, E, Sinning, I. | | Deposit date: | 2014-10-01 | | Release date: | 2014-11-19 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014
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4WJV
 | | Crystal structure of Rsa4 in complex with the Nsa2 binding peptide | | Descriptor: | Maltose-binding periplasmic protein, Ribosome assembly protein 4, Ribosome biogenesis protein NSA2, ... | | Authors: | Holdermann, I, Paternoga, H, Bassler, J, Hurt, E, Sinning, I. | | Deposit date: | 2014-10-01 | | Release date: | 2014-11-19 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014
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