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2R5W
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CRYSTAL STRUCTURE OF A BIFUNCTIONAL NMN ADENYLYLTRANSFERASE/ADP RIBOSE PYROPHOSPHATASE FROM FRANCISELLA TULARENSIS
Descriptor:Nicotinamide-nucleotide adenylyltransferase, MAGNESIUM ION, CHLORIDE ION
Authors:Huang, N., Sorci, L., Zhang, X., Brautigan, C., Li, X., Raffaelli, N., Grishin, N., Osterman, A., Zhang, H.
Deposit date:2007-09-04
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
2QJO
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CRYSTAL STRUCTURE OF A BIFUNCTIONAL NMN ADENYLYLTRANSFERASE/ADP RIBOSE PYROPHOSPHATASE (NADM) COMPLEXED WITH ADPRP AND NAD FROM SYNECHOCYSTIS SP.
Descriptor:Bifunctional NMN adenylyltransferase/Nudix hydrolase, SULFATE ION, ADENOSINE-5-DIPHOSPHORIBOSE, ...
Authors:Huang, N., Sorci, L., Zhang, X., Brautigan, C., Raffaelli, N., Magni, G., Grishin, N.V., Osterman, A., Zhang, H.
Deposit date:2007-07-08
Release date:2008-03-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
2QJT
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CRYSTAL STRUCTURE OF A BIFUNCTIONAL NMN ADENYLYLTRANSFERASE/ADP RIBOSE PYROPHOSPHATASE COMPLEXED WITH AMP AND MN ION FROM FRANCISELLA TULARENSIS
Descriptor:Nicotinamide-nucleotide adenylyltransferase, MANGANESE (II) ION, ADENOSINE MONOPHOSPHATE
Authors:Huang, N., Sorci, L., Zhang, X., Brautigan, C., Raffaelli, N., Magni, G., Grishin, N.V., Osterman, A., Zhang, H.
Deposit date:2007-07-09
Release date:2008-03-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
3GZ5
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CRYSTAL STRUCTURE OF SHEWANELLA ONEIDENSIS NRTR
Descriptor:MutT/nudix family protein, SODIUM ION
Authors:Huang, N., Zhang, H.
Deposit date:2009-04-06
Release date:2009-06-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism
Structure, 17, 2009
3GZ6
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CRYSTAL STRUCTURE OF SHEWANELLA ONEIDENSIS NRTR COMPLEXED WITH A 27MER DNA
Descriptor:MutT/nudix family protein, DNA (27-MER), SODIUM ION
Authors:Huang, N., Zhang, H.
Deposit date:2009-04-06
Release date:2009-06-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism
Structure, 17, 2009
3GZ8
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COCRYSTAL STRUCTURE OF NUDIX DOMAIN OF SHEWANELLA ONEIDENSIS NRTR COMPLEXED WITH ADP RIBOSE
Descriptor:MutT/nudix family protein, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Huang, N., Zhang, H.
Deposit date:2009-04-06
Release date:2009-06-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism
Structure, 17, 2009
3MLA
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BANADD IN COMPLEX WITH INHIBITOR 1_02
Descriptor:nicotinate-nucleotide adenylyltransferase, 4-[2-(anthracen-9-ylmethylidene)hydrazino]-N-(3-chlorophenyl)-4-oxobutanamide, FORMIC ACID, ...
Authors:Huang, N., Eyobo, Y., Zhang, H.
Deposit date:2010-04-16
Release date:2010-07-28
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
J.Med.Chem., 53, 2010
3MLB
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BANADD IN COMPLEX WITH INHIBITOR 1_02_1
Descriptor:nicotinate-nucleotide adenylyltransferase, POTASSIUM ION, FORMIC ACID, ...
Authors:Huang, N., Zhang, H., Eyobo, Y.
Deposit date:2010-04-16
Release date:2010-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
J.Med.Chem., 53, 2010
3MMX
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BACILLUS ANTHRACIS NADD (BANADD) IN COMPLEX WITH COMPOUND 1_02_3
Descriptor:nicotinate-nucleotide adenylyltransferase, POTASSIUM ION, CITRIC ACID, ...
Authors:Huang, N., Zhang, H.
Deposit date:2010-04-20
Release date:2010-07-28
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.552 Å)
Cite:Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
J.Med.Chem., 53, 2010
4F3L
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CRYSTAL STRUCTURE OF THE HETERODIMERIC CLOCK:BMAL1 TRANSCRIPTIONAL ACTIVATOR COMPLEX
Descriptor:BMAL1b, Circadian locomoter output cycles protein kaput
Authors:Huang, N., Chelliah, Y., Shan, Y., Taylor, C., Yoo, S., Partch, C., Green, C.B., Zhang, H., Takahashi, J.
Deposit date:2012-05-09
Release date:2012-06-06
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.268 Å)
Cite:Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337, 2012
3PJA
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CRYSTAL STRUCTURE OF HUMAN C3PO COMPLEX
Descriptor:Translin, Translin-associated protein X
Authors:Huang, N., Zhang, H.
Deposit date:2010-11-09
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of C3PO and mechanism of human RISC activation.
Nat.Struct.Mol.Biol., 18, 2011
1SKM
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HHAI METHYLTRANSFERASE IN COMPLEX WITH DNA CONTAINING AN ABASIC SOUTH CARBOCYCLIC SUGAR AT ITS TARGET SITE
Descriptor:5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ...
Authors:Horton, J.R., Ratner, G., Banavali, N., Huang, N., Marquez, V.E., MacKerell, A.D., Cheng, X.
Deposit date:2004-03-05
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase
Nucleic Acids Res., 32, 2004
2Z8M
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STRUCTURAL BASIS FOR THE CATALYTIC MECHANISM OF PHOSPHOTHREONINE LYASE
Descriptor:27.5 kDa virulence protein
Authors:Chen, L., Wang, H., Gu, L., Huang, N., Zhou, J.M., Chai, J.
Deposit date:2007-09-07
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the catalytic mechanism of phosphothreonine lyase.
Nat.Struct.Mol.Biol., 15, 2008
2Z8N
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STRUCTURAL BASIS FOR THE CATALYTIC MECHANISM OF PHOSPHOTHREONINE LYASE
Descriptor:27.5 kDa virulence protein, SULFATE ION
Authors:Chen, L., Wang, H., Gu, L., Huang, N., Zhou, J.M., Chai, J.
Deposit date:2007-09-07
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the catalytic mechanism of phosphothreonine lyase.
Nat.Struct.Mol.Biol., 15, 2008
2Z8O
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STRUCTURAL BASIS FOR THE CATALYTIC MECHANISM OF PHOSPHOTHREONINE LYASE
Descriptor:27.5 kDa virulence protein, L(+)-TARTARIC ACID
Authors:Chen, L., Wang, H., Gu, L., Huang, N., Zhou, J.M., Chai, J.
Deposit date:2007-09-07
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the catalytic mechanism of phosphothreonine lyase.
Nat.Struct.Mol.Biol., 15, 2008
2Z8P
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STRUCTURAL BASIS FOR THE CATALYTIC MECHANISM OF PHOSPHOTHREONINE LYASE
Descriptor:27.5 kDa virulence protein, (GLY)(GLU)(ALA)(TPO)(VAL)(PTR)(ALA)
Authors:Chen, L., Wang, H., Gu, L., Huang, N., Zhou, J.M., Chai, J.
Deposit date:2007-09-07
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the catalytic mechanism of phosphothreonine lyase.
Nat.Struct.Mol.Biol., 15, 2008
3HFJ
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BACILLUS ANTHRACIS NICOTINATE MONONUCLEOTIDE ADENYLYTRANSFERASE (NADD) IN COMPLEX WITH INHIBITOR CID 3289443
Descriptor:Nicotinate (Nicotinamide) nucleotide adenylyltransferase, 3-amino-N-(3-fluorophenyl)-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide, CALCIUM ION
Authors:Zhang, H., Huang, N., Eyobo, Y.
Deposit date:2009-05-11
Release date:2009-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.
Chem.Biol., 16, 2009
3QB5
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HUMAN C3PO COMPLEX IN THE PRESENCE OF MNSO4
Descriptor:Translin, Translin-associated protein X, SODIUM ION, ...
Authors:Ye, X., Huang, N., Liu, Y., Paroo, Z., Chen, S., Zhang, H., Liu, Q.
Deposit date:2011-01-12
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of C3PO and mechanism of human RISC activation.
Nat.Struct.Mol.Biol., 18, 2011
4GNT
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COMPLEX OF CHREBP AND 14-3-3BETA
Descriptor:14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, SULFATE ION
Authors:Zhang, H., Huang, N.
Deposit date:2012-08-17
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of Carbohydrate Response Element Binding Protein (ChREBP) in complex with 14-3-3b
To be Published
4I41
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CRYSTAL STRUCTURE OF HUMAN SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE
Descriptor:Serine/threonine-protein kinase pim-1, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE
Authors:Zhang, W., Wan, X., Xie, Y., Huang, N.
Deposit date:2012-11-27
Release date:2013-12-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of human Ser/Thr kinase Pim1 in complex with mitoxantrone
To be Published
4IAA
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CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH THIORIDAZINE
Descriptor:Serine/threonine-protein kinase pim-1, 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine
Authors:Zhang, W., Wan, X., Li, W., Xie, Y., Huang, N.
Deposit date:2012-12-06
Release date:2013-12-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine
To be Published
4MED
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CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH THIORIDAZINE DERIVATIVES
Descriptor:Serine/threonine-protein kinase pim-1, 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine
Authors:Zhang, W., Wan, X., Li, W., Xie, Y., Huang, N.
Deposit date:2013-08-26
Release date:2014-02-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives
To be Published
4RBL
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CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES
Descriptor:Serine/threonine-protein kinase pim-1, 1,4,5,8-tetrahydroxyanthracene-9,10-dione
Authors:Zhang, W., Wan, X., Huang, N.
Deposit date:2014-09-12
Release date:2015-03-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives
To be Published, 2014
4RC2
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CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES
Descriptor:Serine/threonine-protein kinase pim-1, 1-amino-5,8-dihydroxy-4-({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione
Authors:Zhang, W., Wan, X., Huang, N.
Deposit date:2014-09-14
Release date:2015-03-18
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives
To be Published
4RC3
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CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES
Descriptor:Serine/threonine-protein kinase pim-1, 1,4-dihydroxy-5,8-bis{[2-(2-hydroxyethoxy)ethyl]amino}anthracene-9,10-dione
Authors:Zhang, W., Wan, X., Huang, N.
Deposit date:2014-09-14
Release date:2015-03-18
Method:X-RAY DIFFRACTION (2.338 Å)
Cite:Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives
To be Published
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