Author results

1FSG
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TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH 9-DEAZAGUANINE, ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE (PRPP) AND TWO MG2+ IONS
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Heroux, A., White, E.L., Ross, L.J., Kuzin, A.P., Borhani, D.W.
Deposit date:2000-09-08
Release date:2000-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis.
Structure Fold.Des., 8, 2000
1QK3
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TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE GMP COMPLEX
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, GUANOSINE-5'-MONOPHOSPHATE
Authors:Heroux, A., White, E.L., Ross, L.J., Borhani, D.W.
Deposit date:1999-07-09
Release date:1999-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structures of the Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase Gmp and -Imp Complexes: Comparison of Purine Binding Interactions with the Xmp Complex
Biochemistry, 38, 1999
1QK4
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TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IMP COMPLEX
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, INOSINIC ACID
Authors:Heroux, A., White, E.L., Ross, L.J., Borhani, D.W.
Deposit date:1999-07-09
Release date:1999-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of the Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase Gmp and -Imp Complexes: Comparison of Purine Binding Interactions with the Xmp Complex
Biochemistry, 38, 1999
1QK5
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TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH XMP, PYROPHOSPHATE AND TWO MG2+ IONS
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, XANTHOSINE-5'-MONOPHOSPHATE, PYROPHOSPHATE 2-, ...
Authors:Heroux, A., White, E.L., Ross, L.J., Davis, R.L., Borhani, D.W.
Deposit date:1999-07-09
Release date:1999-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase with Xmp, Pyrophosphate and Two Mg2+ Ions Bound: Insights Into the Catalytic Mechanism
Biochemistry, 38, 1999
3D9D
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NITROALKANE OXIDASE: MUTANT D402N CRYSTALLIZED WITH 1-NITROHEXANE
Descriptor:Nitroalkane oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 1-nitrohexane, ...
Authors:Heroux, A., Bozinovski, D.M., Valley, M.P., Fitzpatrick, P.F., Orville, A.M.
Deposit date:2008-05-27
Release date:2009-04-07
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of intermediates in the nitroalkane oxidase reaction.
Biochemistry, 48, 2009
3D9E
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NITROALKANE OXIDASE: ACTIVE SITE MUTANT D402N CRYSTALLIZED WITH 1-NITROOCTANE
Descriptor:Nitroalkane oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 1-nitrooctane, ...
Authors:Heroux, A., Bozinovski, D.M., Valley, M.P., Fitzpatrick, P.F., Orville, A.M.
Deposit date:2008-05-27
Release date:2009-04-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of intermediates in the nitroalkane oxidase reaction.
Biochemistry, 48, 2009
3D9F
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NITROALKANE OXIDASE: ACTIVE SITE MUTANT S276A CRYSTALLIZED WITH 1-NITROHEXANE
Descriptor:Nitroalkane oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 1-nitrohexane, ...
Authors:Heroux, A., Bozinovski, D.M., Valley, M.P., Fitzpatrick, P.F., Orville, A.M.
Deposit date:2008-05-27
Release date:2009-04-07
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of intermediates in the nitroalkane oxidase reaction.
Biochemistry, 48, 2009
3D9G
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NITROALKANE OXIDASE: WILD TYPE CRYSTALLIZED IN A TRAPPED STATE FORMING A CYANOADDUCT WITH FAD
Descriptor:Nitroalkane oxidase, FLAVIN-ADENINE DINUCLEOTIDE, heptanenitrile, ...
Authors:Heroux, A., Bozinovski, D.M., Valley, M.P., Fitzpatrick, P.F., Orville, A.M.
Deposit date:2008-05-27
Release date:2009-04-07
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structures of intermediates in the nitroalkane oxidase reaction.
Biochemistry, 48, 2009
3FCJ
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NITROALKANE OXIDASE: MUTANT402N CRYSTALLIZED WITH NITROETHANE
Descriptor:Nitroalkane oxidase, FLAVIN-ADENINE DINUCLEOTIDE, nitroethane, ...
Authors:Major, D.T., Gao, J., Heroux, A., Orville, A.M., Valley, M.P., Fitzpatrick, P.F.
Deposit date:2008-11-21
Release date:2009-11-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Differential quantum tunneling contributions in nitroalkane oxidase catalyzed and the uncatalyzed proton transfer reaction.
Proc.Natl.Acad.Sci.USA, 106, 2009
5F81
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ACOUSTIC INJECTORS FOR DROP-ON-DEMAND SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Lysozyme C, SODIUM ION, CHLORIDE ION
Authors:Roessler, C.G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J.F.R., Bommer, M., Brewster, A.S., Browne, M.C., Chatterjee, R., Cho, E., Cohen, A.E., Cowan, M., Datwani, S., Davidson, V.L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L.P., Glownia, J.M., Han, G., Hattne, J., Hellmich, J., Heroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H.T., Liu, P., Majlof, L., McClintock, W.M., Myers, S., Nelsen, S., Olechno, J., Orville, A.M., Sauter, N.K., Soares, A.S., Soltis, M.S., Song, H., Stearns, R.G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C.M., Yachandra, V., Yano, J., Yukl, E.T., Zhu, D., Zouni, A.
Deposit date:2015-12-08
Release date:2016-02-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.
Structure, 24, 2016
5HL4
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ACOUSTIC INJECTORS FOR DROP-ON-DEMAND SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Ring-hydroxylating dioxygenase, FE2/S2 (INORGANIC) CLUSTER, FE (III) ION, ...
Authors:Roessler, C.G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J.F.R., Bommer, M., Brewster, A.S., Browne, M.C., Chatterjee, R., Cho, E., Cohen, A.E., Cowan, M., Datwani, S., Davidson, V.L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L.P., Glownia, J.M., Han, G., Hattne, J., Hellmich, J., Heroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H.T., Liu, P., Majlof, L., McClintock, W.M., Myers, S., Nelsen, S., Olechno, J., Orville, A.M., Sauter, N.K., Soares, A.S., Soltis, M.S., Song, H., Stearns, R.G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C.M., Yachandra, V., Yano, J., Yukl, E.T., Zhu, D., Zouni, A.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.
Structure, 24, 2016
5HQD
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ACOUSTIC INJECTORS FOR DROP-ON-DEMAND SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Thermolysin, CALCIUM ION, ZINC ION
Authors:Roesser, C.G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J.F.R., Bommer, M., Brewster, A.S., Browne, M.C., Chatterjee, R., Cho, E., Cohen, A.E., Cowan, M., Datwani, S., Davidson, V.L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L.P., Glownia, J.M., Han, G., Hattne, J., Hellmich, J., Heroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H.T., Liu, P., Majlof, L., McClintock, W.M., Myers, S., Nelsen, S., Olechno, J., Orville, A.M., Sauter, N.K., Soares, A.S., Soltis, M.S., Song, H., Stearns, R.G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C.M., Yachandra, V., Yano, J., Yukl, E.T., Zhu, D., Zouni, A.
Deposit date:2016-01-21
Release date:2016-02-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.
Structure, 24, 2016
2REH
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MECHANISTIC AND STRUCTURAL ANALYSES OF THE ROLES OF ARG409 AND ASP402 IN THE REACTION OF THE FLAVOPROTEIN NITROALKANE OXIDASE
Descriptor:Nitroalkane oxidase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Fitzpatrick, P.F., Bozinovski, D.M., Heroux, A., Shaw, P.G., Valley, M.P., Orville, A.M.
Deposit date:2007-09-26
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase.
Biochemistry, 46, 2007
2ZAF
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MECHANISTIC AND STRUCTURAL ANALYSES OF THE ROLES OF ARG409 AND ASP402 IN THE REACTION OF THE FLAVOPROTEIN NITROALKANE OXIDASE
Descriptor:Nitroalkane oxidase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Fitzpatrick, P.F., Bozinovski, D.M., Heroux, A., Shaw, P.G., Valley, M.P., Orville, A.M.
Deposit date:2007-10-05
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase.
Biochemistry, 46, 2007
3LX0
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CRYSTAL STRUCTURE OF STAPHYLOCOCCAL NUCLEASE VARIANT DELTA+PHS D21N AT CRYOGENIC TEMPERATURE
Descriptor:Thermonuclease, THYMIDINE-3',5'-DIPHOSPHATE, PHOSPHATE ION
Authors:Doctrow, B.M., Schlessman, J.L., Garcia-Moreno, E.B., Heroux, A.
Deposit date:2010-02-24
Release date:2011-02-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cooperative Proton Binding in a Cluster of Carboxylic Residues
To be Published
3RLE
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CRYSTAL STRUCTURE OF GRASP55 GRASP DOMAIN (RESIDUES 7-208)
Descriptor:Golgi reassembly-stacking protein 2
Authors:Truschel, S.T., Sengupta, D., Foote, A., Heroux, A., Macbeth, M.R., Linstedt, A.D.
Deposit date:2011-04-19
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:Structure of the Membrane-tethering GRASP Domain Reveals a Unique PDZ Ligand Interaction That Mediates Golgi Biogenesis.
J.Biol.Chem., 286, 2011
3TED
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CRYSTAL STRUCTURE OF THE CHD1 DNA-BINDING DOMAIN IN COMPLEX WITH A DNA DUPLEX
Descriptor:Chromo domain-containing protein 1, 5'-D(*CP*CP*AP*TP*AP*TP*AP*TP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*TP*AP*TP*AP*TP*AP*TP*GP*G)-3'
Authors:Sharma, A., Jenkins, K.R., Heroux, A., Bowman, G.D.
Deposit date:2011-08-12
Release date:2011-11-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:DNA-binding domain of Chd1 in complex with a DNA duplex
J.Biol.Chem., 2011
1KMS
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HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9439), A LIPOPHILIC ANTIFOLATE
Descriptor:DIHYDROFOLATE REDUCTASE, SULFATE ION, 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, ...
Authors:Klon, A.E., Heroux, A., Ross, L.J., Pathak, V., Johnson, C.A., Piper, J.R., Borhani, D.W.
Deposit date:2001-12-17
Release date:2002-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.
J.Mol.Biol., 320, 2002
1KMV
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HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE
Descriptor:DIHYDROFOLATE REDUCTASE, SULFATE ION, (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, ...
Authors:Klon, A.E., Heroux, A., Ross, L.J., Pathak, V., Johnson, C.A., Piper, J.R., Borhani, D.W.
Deposit date:2001-12-17
Release date:2002-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.
J.Mol.Biol., 320, 2002
1R7S
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PUTIDAREDOXIN (FE2S2 FERREDOXIN), C73G MUTANT
Descriptor:Putidaredoxin, FE2/S2 (INORGANIC) CLUSTER
Authors:Smith, N., Mayhew, M., Kelly, H., Robinson, H., Heroux, A., Holden, M.J., Gallagher, D.T.
Deposit date:2003-10-22
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure of C73G putidaredoxin from Pseudomonas putida.
Acta Crystallogr.,Sect.D, 60, 2004
1YWM
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF GROUP B STREPTOCOCCUS ALPHA C PROTEIN
Descriptor:C protein alpha-antigen, (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL
Authors:Auperin, T.C., Bolduc, G.R., Baron, M.J., Heroux, A., Filman, D.J., Madoff, L.C., Hogle, J.M.
Deposit date:2005-02-18
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of the N-terminal domain of the group B streptococcus alpha C protein.
J.Biol.Chem., 280, 2005
2FJT
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ADENYLYL CYCLASE CLASS IV FROM YERSINIA PESTIS
Descriptor:Adenylyl cyclase class IV, SULFATE ION
Authors:Gallagher, D.T., Smith, N.N., Kim, S.-K., Reddy, P.T., Robinson, H., Heroux, A.
Deposit date:2006-01-03
Release date:2006-11-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Structure of the class IV adenylyl cyclase reveals a novel fold
J.Mol.Biol., 362, 2006
2G43
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STRUCTURE OF THE ZNF UBP DOMAIN FROM DEUBIQUITINATING ENZYME ISOPEPTIDASE T (ISOT)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION, UNKNOWN ATOM OR ION
Authors:Reyes-Turcu, F.E., Horton, J.R., Mullally, J.E., Heroux, A., Cheng, X., Wilkinson, K.D.
Deposit date:2006-02-21
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin.
Cell(Cambridge,Mass.), 124, 2006
2G45
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CO-CRYSTAL STRUCTURE OF ZNF UBP DOMAIN FROM THE DEUBIQUITINATING ENZYME ISOPEPTIDASE T (ISOT) IN COMPLEX WITH UBIQUITIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin, ZINC ION, ...
Authors:Reyes-Turcu, F.E., Horton, J.R., Mullally, J.E., Heroux, A., Cheng, X., Wilkinson, K.D.
Deposit date:2006-02-21
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin.
Cell(Cambridge,Mass.), 124, 2006
2OVG
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LAMBDA CRO Q27P/A29S/K32Q TRIPLE MUTANT AT 1.35 A IN SPACE GROUP P3221
Descriptor:Phage lambda Cro, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Hall, B.M., Heroux, A., Roberts, S.A., Cordes, M.H.
Deposit date:2007-02-13
Release date:2008-01-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Two structures of a lambda Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA.
J.Mol.Biol., 375, 2008
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