Author results

1K5Q
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PENICILLIN ACYLASE, MUTANT COMPLEXED WITH PAA
Descriptor:PENICILLIN G ACYLASE ALPHA SUBUNIT, PENICILLIN G ACYLASE BETA SUBUNIT, CALCIUM ION, ...
Authors:Hensgens, C.M.H., Keizer, E., Snijder, H.J., Dijkstra, B.W.
Deposit date:2001-10-12
Release date:2003-09-02
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase.
Protein Eng.Des.Sel., 17, 2004
1K5S
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PENICILLIN ACYLASE, MUTANT COMPLEXED WITH PPA
Descriptor:PENICILLIN G ACYLASE ALPHA SUBUNIT, PENICILLIN G ACYLASE BETA SUBUNIT, CALCIUM ION, ...
Authors:Hensgens, C.M.H., Keizer, E., Snijder, H.J., Dijkstra, B.W.
Deposit date:2001-10-12
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase.
Protein Eng.Des.Sel., 17, 2004
1K7D
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PENICILLIN ACYLASE WITH PHENYL PROPRIONIC ACID
Descriptor:Penicillin Acylase alpha subunit, penicillin Acylase beta subunit, CALCIUM ION, ...
Authors:Hensgens, C.M.H., Keizer, E., Snijder, H.J., Dijkstra, B.W.
Deposit date:2001-10-19
Release date:2003-09-02
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase.
Protein Eng.Des.Sel., 17, 2004
1KEC
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PENICILLIN ACYLASE MUTANT WITH PHENYL PROPRIONIC ACID
Descriptor:PENICILLIN ACYLASE ALPHA SUBUNIT, PENICILLIN ACYLASE BETA SUBUNIT, CALCIUM ION, ...
Authors:Hensgens, C.M.H., Keizer, E., Snijder, H.J., Dijkstra, B.W.
Deposit date:2001-11-15
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase.
Protein Eng.Des.Sel., 17, 2004
2X1C
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THE CRYSTAL STRUCTURE OF PRECURSOR ACYL COENZYME A:ISOPENICILLIN N ACYLTRANSFERASE FROM PENICILLIUM CHRYSOGENUM
Descriptor:ACYL-COENZYME, SULFATE ION, GLYCEROL, ...
Authors:Bokhove, M., Yoshida, H., Hensgens, C.M.H., van der Laan, J.M., Sutherland, J.D., Dijkstra, B.W.
Deposit date:2009-12-23
Release date:2010-03-09
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme.
Structure, 18, 2010
2X1D
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THE CRYSTAL STRUCTURE OF MATURE ACYL COENZYME A:ISOPENICILLIN N ACYLTRANSFERASE FROM PENICILLIUM CHRYSOGENUM
Descriptor:ACYL-COENZYME, PHOSPHATE ION, GLYCEROL, ...
Authors:Bokhove, M., Yoshida, H., Hensgens, C.M.H., van der Laan, J.M., Sutherland, J.D., Dijkstra, B.W.
Deposit date:2009-12-23
Release date:2010-03-09
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme.
Structure, 18, 2010
2X1E
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THE CRYSTAL STRUCTURE OF MATURE ACYL COENZYME A:ISOPENICILLIN N ACYLTRANSFERASE FROM PENICILLIUM CHRYSOGENUM IN COMPLEX 6- AMINOPENICILLANIC ACID
Descriptor:ACYL-COENZYME, PHOSPHATE ION, GLYCEROL, ...
Authors:Bokhove, M., Yoshida, H., Hensgens, C.M.H., van der Laan, J.M., Sutherland, J.D., Dijkstra, B.W.
Deposit date:2009-12-23
Release date:2010-03-09
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme.
Structure, 18, 2010
1JX9
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PENICILLIN ACYLASE, MUTANT
Descriptor:penicillin G acylase alpha subunit, penicillin G acylase beta subunit, CALCIUM ION
Authors:Hensgens, C.M.H., Keizer, E., Snijder, H.J., Dijkstra, B.W.
Deposit date:2001-09-06
Release date:2003-09-02
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase.
Protein Eng.Des.Sel., 17, 2004
1BK0
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, SULFATE ION, FE (III) ION, ...
Authors:Roach, P.L., Clifton, I.J., Hensgens, C.M.H., Shibata, N., Schofield, C.J., Hajdu, J., Baldwin, J.E.
Deposit date:1998-07-14
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
Nature, 387, 1997
1BLZ
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE-NO COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, FE (III) ION, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ...
Authors:Roach, P.L., Clifton, I.J., Hensgens, C.M.H., Shibata, N., Schofield, C.J., Hajdu, J., Baldwin, J.E.
Deposit date:1998-07-22
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
Nature, 387, 1997
1MPX
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ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE
Descriptor:alpha-amino acid ester hydrolase, CALCIUM ION, GLYCEROL
Authors:Barends, T.R.M., Polderman-Tijmes, J.J., Jekel, P.A., Hensgens, C.M.H., de Vries, E.J., Janssen, D.B., Dijkstra, B.W.
Deposit date:2002-09-13
Release date:2003-04-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The sequence and crystal structure of the alpha-amino acid ester hydrolase from Xanthomonas citri define a new family of beta-lactam antibiotic acylases.
J.Biol.Chem., 278, 2003
1QIQ
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACMC FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, N-[N-[2-AMINO-6-OXO-HEXANOIC ACID-6-YL]CYSTEINYL]-S-METHYLCYSTEINE, FE (III) ION, ...
Authors:Rutledge, P.J., Clifton, I.J., Burzlaff, N.I., Roach, P.L., Adlington, R.M., Baldwin, J.E.
Deposit date:1999-06-15
Release date:2000-06-16
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Reaction Cycle of Isopenicillin N Synthase Observed by X-Ray Diffraction.
Nature, 401, 1999
1QJE
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (IP1 - FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, SULFATE ION, ISOPENICILLIN N, ...
Authors:Burzlaff, N.I., Clifton, I.J., Rutledge, P.J., Roach, P.L., Adlington, R.M., Baldwin, J.E.
Deposit date:1999-06-23
Release date:2000-06-29
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The Reaction Cycle of Isopenicillin N Synthase Observed by X-Ray Diffraction
Nature, 401, 1999
1QJF
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (MONOCYCLIC SULFOXIDE - FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, SULFATE ION, 1-[(1S)-CARBOXY-2-(METHYLSULFINYL)ETHYL]-(3R)-[(5S)-5-AMINO-5-CARBOXYPENTANAMIDO]-(4R)-SULFANYLAZETIDIN-2-ONE, ...
Authors:Rutledge, P.J., Clifton, I.J., Burzlaff, N.I., Roach, P.L., Adlington, R.M., Baldwin, J.E.
Deposit date:1999-06-23
Release date:2000-06-29
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Reaction Cycle of Isopenicillin N Synthase Observed by X-Ray Diffraction
Nature, 401, 1999
1HB1
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ANAEROBIC ACOV FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, N6-[(1R)-2-{[(1R)-1-CARBOXY-2-METHYLPROPYL]OXY}-1-(MERCAPTOMETHYL)-2-OXOETHYL]-6-OXO-D-LYSINE, SULFATE ION, ...
Authors:Ogle, J.M., Clifton, I.J., Rutledge, P.J., Elkins, J.M., Burzlaff, N.I., Adlington, R.M., Roach, P.L., Baldwin, J.E.
Deposit date:2001-04-11
Release date:2001-11-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Alternative Oxidation by Isopenicillin N Synthase Observed by X-Ray Diffraction.
Chem.Biol., 8, 2001
1HB2
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN EXPOSED PRODUCT FROM ANAEROBIC ACOV FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, N6-[(1S)-2-{[(1R)-1-CARBOXY-2-METHYLPROPYL]OXY}-1-(MERCAPTOCARBONYL)-2-OXOETHYL]-6-OXO-L-LYSINE, SULFATE ION, ...
Authors:Ogle, J.M., Clifton, I.J., Rutledge, P.J., Elkins, J.M., Burzlaff, N.I., Adlington, R.M., Roach, P.L., Baldwin, J.E.
Deposit date:2001-04-11
Release date:2001-11-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Alternative Oxidation by Isopenicillin N Synthase Observed by X-Ray Diffraction.
Chem.Biol., 8, 2001
1HB3
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN EXPOSED PRODUCT FROM ANAEROBIC ACOV FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, N6-[(1S)-2-{[(1R)-1-CARBOXY-2-METHYLPROPYL]OXY}-1-(MERCAPTOCARBONYL)-2-OXOETHYL]-6-OXO-L-LYSINE, SULFATE ION, ...
Authors:Ogle, J.M., Clifton, I.J., Rutledge, P.J., Elkins, J.M., Burzlaff, N.I., Adlington, R.M., Roach, P.L., Baldwin, J.E.
Deposit date:2001-04-11
Release date:2001-11-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Alternative Oxidation by Isopenicillin N Synthase Observed by X-Ray Diffraction.
Chem.Biol., 8, 2001
1HB4
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN EXPOSED PRODUCT FROM ANAEROBIC ACOV FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, N6-[(1S)-2-{[(1R)-1-CARBOXY-2-METHYLPROPYL]OXY}-1-(MERCAPTOCARBONYL)-2-OXOETHYL]-6-OXO-L-LYSINE, SULFATE ION, ...
Authors:Ogle, J.M., Clifton, I.J., Rutledge, P.J., Elkins, J.M., Burzlaff, N.I., Adlington, R.M., Roach, P.L., Baldwin, J.E.
Deposit date:2001-04-11
Release date:2001-11-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Alternative Oxidation by Isopenicillin N Synthase Observed by X-Ray Diffraction.
Chem.Biol., 8, 2001
1ODM
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ANAEROBIC AC-VINYLGLYCINE FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VINYLGLYCINE, SULFATE ION, ...
Authors:Elkins, J.M., Rutledge, P.J., Burzlaff, N.I., Clifton, I.J., Adlington, R.M., Roach, P.L., Baldwin, J.E.
Deposit date:2003-02-19
Release date:2003-06-19
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystallographic Studies on the Reaction of Isopenicillin N Synthase with an Unsaturated Substrate Analogue
Org.Biomol.Chem., 1, 2003
1ODN
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN-EXPOSED PRODUCT FROM ANAEROBIC AC-VINYLGLYCINE FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, 6-(5-AMINO-5-CARBOXY-PENTANOYLAMINO)-3-HYDROXYMETHYL-7-OXO-4-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, SULFATE ION, ...
Authors:Elkins, J.M., Rutledge, P.J., Burzlaff, N.I., Clifton, I.J., Adlington, R.M., Roach, P.L., Baldwin, J.E.
Deposit date:2003-02-19
Release date:2003-06-19
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic Studies on the Reaction of Isopenicillin N Synthase with an Unsaturated Substrate Analogue
Org.Biomol.Chem., 1, 2003
2JB4
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ISOPENICILLIN N SYNTHASE WITH A 2-THIABICYCLOHEPTAN-6-ONE PRODUCT ANALOGUE
Descriptor:ISOPENICILLIN N SYNTHETASE, (1S,4S,5S,7R)-7-{[(5S)-5-AMINO-5-CARBOXYPENTANOYL]AMINO}-3,3-DIMETHYL-6-OXO-2-THIABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID, FE (III) ION, ...
Authors:Stewart, A.C., Clifton, I.J., Adlington, R.M., Baldwin, J.E., Rutledge, P.J.
Deposit date:2006-12-01
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A Cyclobutanone Analogue Mimics Penicillin in Binding to Isopenicillin N Synthase.
Chembiochem, 8, 2007