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2K31
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SOLUTION STRUCTURE OF CGMP-BINDING GAF DOMAIN OF PHOSPHODIESTERASE 5
Descriptor:Phosphodiesterase 5A, cGMP-specific, GUANOSINE-3',5'-MONOPHOSPHATE
Authors:Heikaus, C.C., Stout, J.R., Sekharan, M.R., Eakin, C.M., Rajagopal, P., Brzovic, P.S., Beavo, J.A., Klevit, R.E.
Deposit date:2008-04-16
Release date:2008-06-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change.
J.Biol.Chem., 283, 2008
2LPB
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STRUCTURE OF THE COMPLEX OF THE CENTRAL ACTIVATION DOMAIN OF GCN4 BOUND TO THE MEDIATOR CO-ACTIVATOR DOMAIN 1 OF GAL11/MED15
Descriptor:Mediator of RNA polymerase II transcription subunit 15, General control protein GCN4
Authors:Brzovic, P.S., Heikaus, C.C., Kisselev, L., Vernon, R., Herbig, E., Pacheco, D., Warfield, L., Littlefield, P., Baker, D., Klevit, R.E., Hahn, S.
Deposit date:2012-02-07
Release date:2012-02-22
Method:SOLUTION NMR
Cite:The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex.
Mol.Cell, 44, 2011
3DBA
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CRYSTAL STRUCTURE OF THE CGMP-BOUND GAF A DOMAIN FROM THE PHOTORECEPTOR PHOSPHODIESTERASE 6C
Descriptor:Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', GUANOSINE-3',5'-MONOPHOSPHATE, GLYCEROL
Authors:Martinez, S.E., Heikaus, C.C., Klevit, R.E., Beavo, J.A.
Deposit date:2008-05-30
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change.
J.Biol.Chem., 283, 2008