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4XXH
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TREHALOSE REPRESSOR FROM ESCHERICHIA COLI
Descriptor:HTH-type transcriptional regulator TreR, Trehalose-6-phosphate
Authors:Hars, U., Horlacher, R., Boos, W., Smart, O.S., Bricogne, G., Welte, W., Diederichs, K.
Deposit date:2015-01-30
Release date:2015-02-11
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:CRYSTAL STRUCTURE OF THE EFFECTOR-BINDING DOMAIN OF THE TREHALOSE-REPRESSOR OF ESCHERICHIA COLI, A MEMBER OF THE LACI FAMILY, IN ITS COMPLEXES WITH INDUCER TREHALOSE-6-PHOSPHATE AND NONINDUCER TREHALOSE.
PROTEIN SCI., 7, 1998
5W4V
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STRUCTURE OF RORGT BOUND TO A TERTIARY ALCOHOL
Descriptor:Nuclear receptor ROR-gamma, (R)-(4-chloro-2-methoxy-3-{[4-(1H-pyrazol-1-yl)phenyl]methyl}quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol
Authors:Spurlino, J., Hars, U.
Deposit date:2017-06-13
Release date:2017-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:6-Substituted quinolines as ROR gamma t inverse agonists.
Bioorg. Med. Chem. Lett., 27, 2017
5LGE
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CRYSTAL STRUCTURE OF HUMAN IDH1 MUTANT (R132H) IN COMPLEX WITH NADP+ AND AN INHIBITOR RELATED TO BAY 1436032
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ...
Authors:Hillig, R.C., Hars, U., Korndoerfer, I.P.
Deposit date:2016-07-07
Release date:2017-02-08
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
Acta Neuropathol., 133, 2017