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5XJC
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CRYO-EM STRUCTURE OF THE HUMAN SPLICEOSOME JUST PRIOR TO EXON LIGATION AT 3.6 ANGSTROM
Descriptor:Pre-mRNA-processing-splicing factor 8, U5 snRNA, 116 kDa U5 small nuclear ribonucleoprotein component, ...
Authors:Zhang, X., Yan, C., Hang, J., Finci, I.L., Lei, J., Shi, Y.
Deposit date:2017-04-30
Release date:2017-07-05
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:An Atomic Structure of the Human Spliceosome
Cell, 169, 2017
3JB9
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CRYO-EM STRUCTURE OF THE YEAST SPLICEOSOME AT 3.6 ANGSTROM RESOLUTION
Descriptor:Pre-mRNA-splicing factor spp42, Pre-mRNA-splicing factor cwf10, U5 snRNA, ...
Authors:Yan, C., Hang, J., Wan, R., Huang, M., Wong, C., Shi, Y.
Deposit date:2015-08-09
Release date:2015-09-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a yeast spliceosome at 3.6-angstrom resolution
Science, 349, 2015
4M75
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CRYSTAL STRUCTURE OF LSM1-7 COMPLEX
Descriptor:U6 snRNA-associated Sm-like protein Lsm1, U6 snRNA-associated Sm-like protein Lsm2, U6 snRNA-associated Sm-like protein Lsm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-10-23
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M77
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX, SPACE GROUP I212121
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3.111 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M78
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX, SPACE GROUP P21
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M7A
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX BOUND TO THE 3' END SEQUENCE OF U6 SNRNA
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M7D
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX BOUND TO THE RNA FRAGMENT CGUUU
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4N0G
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CRYSTAL STRUCTURE OF PYL13-PP2CA COMPLEX
Descriptor:Protein phosphatase 2C 37, Abscisic acid receptor PYL13, ZINC ION, ...
Authors:Li, W., Wang, L., Sheng, X., Yan, C., Zhou, R., Hang, J., Yin, P., Yan, N.
Deposit date:2013-10-01
Release date:2013-11-13
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13
Cell Res., 23, 2013
1FEJ
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-21
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FF0
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-24
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FFF
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FFI
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FG6
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FG8
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FGC
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-28
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
5MPS
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STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION
Descriptor:Yeast UBC4 gene for ubiquitin-conjugating enzyme, UBC4 gene exon, U2 snRNA, ...
Authors:Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K.
Deposit date:2016-12-18
Release date:2017-01-18
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
5MQ0
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STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION
Descriptor:Yeast UBC4 gene for ubiquitin-conjugating enzyme, 5'-EXON OF UBC4 PRE-MRNA, S.cerevisiae chromosome II reading frame ORF YBR230c, ...
Authors:Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017