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5UFX
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BU of 5ufx by Molmil
Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1074
Descriptor: (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-1-benzopyran-7-ol, Estrogen receptor
Authors:Fanning, S.W, Hodges-Gallagher, L, Myles, D.C, Sun, R, Fowler, C.E, Green, B.D, Harmon, C.L, Greene, G.L, Kushner, P.J.
Deposit date:2017-01-06
Release date:2018-01-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5503 Å)
Cite:Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Nat Commun, 9, 2018
5UFW
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BU of 5ufw by Molmil
Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1154
Descriptor: (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-1-benzopyran-7-ol, Estrogen receptor
Authors:Fanning, S.W, Hodges-Gallagher, L, Myles, D.C, Sun, R, Fowler, C.E, Green, B.D, Harmon, C.L, Greene, G.L, Kushner, P.J.
Deposit date:2017-01-06
Release date:2018-01-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.583 Å)
Cite:Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Nat Commun, 9, 2018
6C42
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BU of 6c42 by Molmil
Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1156
Descriptor: (2R,3S,4R)-3-(4-hydroxyphenyl)-4-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydro-2H-1-benzopyran-7-ol, Estrogen receptor
Authors:Fanning, S.W, Hodges-Gallager, L, Myles, D.C, Sun, R, Fowler, C.E, Green, B.D, Harmon, C.L, Greene, G.L, Kushner, P.J.
Deposit date:2018-01-11
Release date:2018-02-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Nat Commun, 9, 2018
8DL3
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BU of 8dl3 by Molmil
Crystal structure of the human queuine salvage enzyme DUF2419, complexed with queuine
Descriptor: 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, Queuosine salvage protein
Authors:Hung, S.-H, Swairjo, M.A.
Deposit date:2022-07-06
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
7U07
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BU of 7u07 by Molmil
Crystal structure of queuine salvage enzyme DUF2419, apo form
Descriptor: Queuine salvage enzyme DUF2419
Authors:Hung, S.-H, Swairjo, M.A.
Deposit date:2022-02-17
Release date:2022-12-21
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
7U91
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BU of 7u91 by Molmil
Crystal structure of queuine salvage enzyme DUF2419, in complex with queuosine-5'-monophosphate
Descriptor: 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-(5-O-phosphono-beta-D-ribofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Hung, S.-H, Swairjo, M.A.
Deposit date:2022-03-09
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
7U1O
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BU of 7u1o by Molmil
Crystal structure of queuine salvage enzyme DUF2419 complexed with queuosine
Descriptor: 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-beta-D-ribofuranosyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, MALONATE ION, ...
Authors:Hung, S.-H, Swairjo, M.A.
Deposit date:2022-02-21
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
7U5A
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BU of 7u5a by Molmil
Crystal structure of queuine salvage enzyme DUF2419 mutant K199C, complexed with queuosine
Descriptor: 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-beta-D-ribofuranosyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, MALONATE ION, Queuine salvage enzyme DUF2419
Authors:Hung, S.-H, Swairjo, M.A.
Deposit date:2022-03-01
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
7UGK
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BU of 7ugk by Molmil
Crystal structure of the human queuine salvage enzyme DUF2419, wild-type apo form
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Queuosine salvage protein DUF2419
Authors:Hung, S.-H, Swairjo, M.A.
Deposit date:2022-03-24
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
7UK3
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BU of 7uk3 by Molmil
Crystal structure of queuine salvage enzyme DUF2419, wild-type (non-His6x tagged)
Descriptor: Queuosine salvage protein DUF2419
Authors:Hung, S.-H, Swairjo, M.A.
Deposit date:2022-03-31
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
7ULC
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BU of 7ulc by Molmil
Crystal structure of queuine salvage enzyme DUF2419 mutant D231N, in complex with queuosine-5'-monophosphate
Descriptor: 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-(5-O-phosphono-beta-D-ribofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, Queuosine salvage protein DUF2419
Authors:Hung, S.-H, Swairjo, M.A.
Deposit date:2022-04-04
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
8C8J
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BU of 8c8j by Molmil
Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP
Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, ...
Authors:Nichols, C.E, Walpole, T.B, Baldwin, E.
Deposit date:2023-01-20
Release date:2023-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature, 626, 2024
8SXU
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BU of 8sxu by Molmil
Structure of LINE-1 ORF2p with an oligo(A) template
Descriptor: LINE-1 retrotransposable element ORF2 protein, RNA (25-MER)
Authors:van Eeuwen, T, Taylor, M.S, Rout, M.P.
Deposit date:2023-05-24
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature, 626, 2024
8SXT
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BU of 8sxt by Molmil
Structure of LINE-1 ORF2p with template:primer hybrid
Descriptor: DNA primer, LINE-1 retrotransposable element ORF2 protein, MAGNESIUM ION, ...
Authors:van Eeuwen, T, Taylor, M.S, Rout, M.P.
Deposit date:2023-05-24
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature, 626, 2024

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PDB entries from 2024-09-18

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