Author results

2AQU
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STRUCTURE OF HIV-1 PROTEASE BOUND TO ATAZANAVIR
Descriptor:HIV-1 Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5,6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER
Authors:Clemente, J.C., Coman, R.M., Thiaville, M.M., Janka, L.K., Jeung, J.A., Nukoolkarn, S., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Leelamanit, W., Goodenow, M.M., Dunn, B.M.
Deposit date:2005-08-18
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
Biochemistry, 45, 2006
1SGU
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COMPARING THE ACCUMULATION OF ACTIVE SITE AND NON-ACTIVE SITE MUTATIONS IN THE HIV-1 PROTEASE
Descriptor:POL polyprotein, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Clemente, J.C., Moose, R.E., Hemrajani, R., Govindasamy, L., Reutzel, R., Mckenna, R., Abandje-McKenna, M., Goodenow, M.M., Dunn, B.M.
Deposit date:2004-02-24
Release date:2004-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease.
Biochemistry, 43, 2004
1SH9
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COMPARING THE ACCUMULATION OF ACTIVE SITE AND NON-ACTIVE SITE MUTATIONS IN THE HIV-1 PROTEASE
Descriptor:POL polyprotein, RITONAVIR
Authors:Clemente, J.C., Moose, R.E., Hemrajani, R., Govindasamy, L., Reutzel, R., McKenna, R., Abanje-McKenna, M., Goodenow, M.M., Dunn, B.M.
Deposit date:2004-02-25
Release date:2004-10-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease.
Biochemistry, 43, 2004
2B60
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STRUCTURE OF HIV-1 PROTEASE MUTANT BOUND TO RITONAVIR
Descriptor:Gag-Pol polyprotein, GLYCEROL, RITONAVIR
Authors:Clemente, J.C., Stow, L.R., Janka, L.K., Jeung, J.A., Desai, K.A., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Goodenow, M.M., Dunn, B.M.
Deposit date:2005-09-29
Release date:2006-11-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:In vivo, kinetic, and structural analysis of the development of ritonavir resistance
To be Published
2B7Z
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STRUCTURE OF HIV-1 PROTEASE MUTANT BOUND TO INDINAVIR
Descriptor:HIV-1 protease, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Clemente, J.C., Stow, L.R., Janka, L.K., Jeung, J.A., Desai, K.A., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Goodenow, M.M., Dunn, B.M.
Deposit date:2005-10-05
Release date:2006-11-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:In vivo, kinetic, and structural analysis of the development of ritonavir resistance
To be Published
1FIV
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STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS
Descriptor:FIV PROTEASE, FIV PROTEASE INHIBITOR ACE-ALN-VAL-STA-GLU-ALN-NH2
Authors:Wlodawer, A., Gustchina, A., Reshetnikova, L., Lubkowski, J., Zdanov, A.
Deposit date:1995-05-04
Release date:1995-07-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus.
Nat.Struct.Biol., 2, 1995
2R5P
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 SUBTYPE C PROTEASE COMPLEXED WITH INDINAVIR
Descriptor:Protease, CHLORIDE ION, SODIUM ION, ...
Authors:Coman, R.M., Robbins, A.H., McKenna, R., Dunn, B.M.
Deposit date:2007-09-04
Release date:2007-11-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Contribution of Naturally Occurring Polymorphisms in Altering the Biochemical and Structural Characteristics of HIV-1 Subtype C Protease
Biochemistry, 47, 2008
2R5Q
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 SUBTYPE C PROTEASE COMPLEXED WITH NELFINAVIR
Descriptor:Protease, 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE
Authors:Coman, R.M., Robbins, A.H., McKenna, R., Dunn, B.M.
Deposit date:2007-09-04
Release date:2007-11-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Contribution of Naturally Occurring Polymorphisms in Altering the Biochemical and Structural Characteristics of HIV-1 Subtype C Protease
Biochemistry, 47, 2008
2R8N
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STRUCTURAL ANALYSIS OF THE UNBOUND FORM OF HIV-1 SUBTYPE C PROTEASE
Descriptor:Pol protein, GLYCEROL
Authors:Coman, R.M., Robbins, A.H., McKenna, R., Dunn, B.M.
Deposit date:2007-09-11
Release date:2008-07-29
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance.
Acta Crystallogr.,Sect.D, 64, 2008
2FIV
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CRYSTAL STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH A SUBSTRATE
Descriptor:FELINE IMMUNODEFICIENCY VIRUS PROTEASE, ACE-ALN-VAL-STA-GLU-ALN-NH2, SULFATE ION
Authors:Schalk-Hihi, C., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1997-07-21
Release date:1997-11-12
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry, 36, 1997
3FIV
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CRYSTAL STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH A SUBSTRATE
Descriptor:FELINE IMMUNODEFICIENCY VIRUS PROTEASE, ACE-ALN-VAL-LEU-ALA-GLU-ALN-NH2, SULFATE ION
Authors:Schalk-Hihi, C., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1997-07-09
Release date:1997-11-12
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry, 36, 1997